Association of rs1800629 tumor necrosis factor alpha polymorphism with risk of prostate tumors of Iraqi patients

No association between three polymorphisms (rs1800629, rs361525 and rs1799724) in the tumor necrosis factor-α gene and susceptibility to prostate cancer: a comprehensive meta-analysis

“…Therefore, a current, updated meta-analysis with a comprehensive assessment that included more eligible studies was performed to evaluate the impact of TNF-α gene polymorphisms (rs1800629, rs361525 and rs1799724) on PCA susceptibility, which may overcome the aforementioned disadvantages [15,16,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. For the TNF-α rs1800629 polymorphism, the findings from 20 studies, including 6936 cases and 7619 controls, did not support an association between this variant and PCA risk [15,16,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. To the best of our knowledge, for the rs1799724 [15,16,35] polymorphism, which was analyzed for the first time, no significant association was detected from 3 studies, which included 2914 cases and 3121 controls.…”

“…Ma et al, however, suggested that the rs361525 polymorphism was not associated with PCA, and the rs1800629 polymorphism, which is also the susceptible SNP for PCA, only had a significant association in healthy volunteers (AG vs. GG: OR = 1.47, 95% CI = 1.04-2.08) [18]. Due to these inconclusive results, as well as the publication of some additional studies, it was necessary to re-combine all of the articles, including 22 different case-control studies [15,16,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36], to conduct an updated meta-analysis.…”

“…meta-analysis(Table 1,Fig. 1)[15,16,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. Of the 22 studies, TNF-α rs1800629 was analyzed in 22 studies; rs361525, in 8 studies; rs1799724, in 5 studies; and rs1799964, in 3 studies.…”