Association of rs10830962 polymorphism with gestational diabetes mellitus risk in a Chinese population

Abstract

To date, only three polymorphisms (rs10830962, rs7754840 and rs1470579) are included in the genome-wide association study Catalog ( www.ebi.ac.uk/gwas ). However, the available evidence is limited in pregnant Chinese women. We aimed to explore the associations of three polymorphisms (rs10830962, rs7754840 and rs1470579) with GDM risk in a Chinese population. We conducted a case-control study (964 GDM cases and 1,021 controls) to evaluate the associations of these polymorphisms with GDM risk. A logistic regression model was used to calculate odds ratios (ORs) and their confidence intervals (CIs). After adjustment for age, prepregnancy BMI, parity, abnormal pregnancy history and family history of diabetes, the minor allele of rs10830962 (C > G) demonstrated a significant association with an increased risk of GDM (OR = 1.16, 95% CI = 1.02–1.31, P = 0.029 in the additive model). However, no significant association was observed between the other two polymorphisms and GDM. Subsequent functional annotation shows that rs10830962 is located in the regulatory elements of pancreatic islets, alters the binding affinity of motifs and regulates SNORA8 expression. Our findings demonstrate that rs10830962 is associated with an increased risk of GDM in the Chinese population. Further functional characterization is warranted to uncover the mechanism of the genotype-phenotype association.

CDKAL1 gene rs7756992 A/G and rs7754840 G/C polymorphisms are associated with gestational diabetes mellitus in a sample of Bangladeshi population: implication for future T2DM prophylaxis

“…The association of these genetic variants with GDM was also studied in a number of populations as this disease may have a common genetic background with T2DM [ 27 , 44 , 45 ]. Recently some studies on rs7756992 and rs7754840 reported significant association in Asian populations [ 26 , 28 , 46 , 47 ] whereas in some populations there was no association found [ 45 , 48 ]. Nevertheless, no report is available on the association of CDKAL1 rs7756992 and rs7754840 SNPs with GDM in Bangladeshi women.…”

Lack of association between IGF2BP2 rs4402960 polymorphism and gestational diabetes mellitus: a case–control study, meta-analysis and trial sequential analysis

“…To date, researchers investigated the association between three IGF2BP2 polymorphisms (rs4402960, rs1470579, rs11705701) and GDM. There was no evidence of the association between IGF2BP2 rs1470579 or rs11705701 and risk of GDM [9,10]. Recently, the association between IGF2BP2 rs4402960 polymorphism and risk of GDM has been discussed in many studies [11,12].…”

Genomics and Epigenomics of Gestational Diabetes Mellitus: Understanding the Molecular Pathways of the Disease Pathogenesis

“…It is expressed in the pancreatic islets and plays a role in glucose homeostasis during pregnancy via the melatonin signaling pathway [ 74 ]. Three SNPs have been reported to be associated with elevated GDM risk (rs10830962, rs10830963, rs1387153) [ 37 , 38 , 49 , 51 , 52 ]. RS10830962 was associated with GDM in the Chinese population [ 51 ].…”

“…Three SNPs have been reported to be associated with elevated GDM risk (rs10830962, rs10830963, rs1387153) [ 37 , 38 , 49 , 51 , 52 ]. RS10830962 was associated with GDM in the Chinese population [ 51 ]. MTNRB1 polymorphism rs10830963 was found to be associated with GDM in Asians, Caucasians, and Arabs [ 36 , 38 , 49 , 52 ], while rs1387153 was a risk factor for GDM in Mexicans, Finnish, Danish, and Arab populations [ 36 , 37 , 38 , 49 ].…”