Association of risk factor variables and coronary artery disease documented with angiography.

Holmes, David R.; Elveback, Lila R.; Frye, Robert L.; Kottke, Bruce A.; Ellefson, Ralph D.

doi:10.1161/01.cir.63.2.293

Cited by 106 publications

(33 citation statements)

References 24 publications

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“…Our findings demonstrate a closer association of tobacco consumption with the development of myocardial infarction in young patients than in older age groups, consistent with the known significant coronary risk of tobacco consumption. 2,3,[28][29][30] Clinical features. There are conflicting reports concerning the clinical course and natural history of myocardial infarction in young patients.…”

Section: Discussionmentioning

confidence: 99%

Myocardial infarction in young patients: an analysis by age subsets.

Hoit¹,

Gilpin²,

Henning³

et al. 1986

Circulation

198

104

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We examined, in age subsets, 2643 patients with acute myocardial infarction. Clinical features and 1 year morbidity and mortality were compared in 203 young patients (<45 years), 1671 patients 46 to 70 years old, and 769 elderly patients (>70 years). Ninety-two percent of young patients were men, and a family history of premature coronary artery disease was more common in young patients (41% compared with 28% of middle-aged and 12% of elderly patients). More young patients were currently smoking cigarettes (82% compared with 56% of middle-aged and 24% of elderly patients), and only 8% of young patients had never smoked. Previous myocardial infarction and history of angina pectoris or congestive heart failure were less common (p < .001) in the young patients than in middle-aged and elderly patients. In-hospital mortality was only 2.5% for young patients, compared with 9.0% in middle-aged and 21.4% in elderly patients (both p < .001). Postdischarge 1 year mortality was also strikingly low in young patients, at 2.6% compared with 10.3% in middle-aged and 24.4% in elderly patients. The incidence of reinfarction during the 1 year of follow-up was similar in all subsets. The statistical significance of 65 variables as predictors of 1 year mortality and reinfarction was tested and the following found to be significant (p < .05): hospital discharge on antiarrhythmic drugs, digoxin, or diuretics; history of previous myocardial infarction or congestive heart failure; chest x-ray findings of heart failure; low ejection fraction; and atrial fibrillation. Thus, young patients entering the hospital have an excellent 1 year prognosis, but those with prior infarction in whom there are selected abnormal findings at hospital discharge comprise a subgroup that may benefit from early aggressive management. Circulation 74, No. 4, 712-721, 1986. THERE IS A relative paucity of information concerning the clinical features, natural history, and prognosis in young patients with acute myocardial infarction. Despite the relatively low frequency of myocardial infarction in the young population,' the potential for death and long-term disability make this entity an important clinical problem. A number of studies have examined the epidemiologic features and the coronary arterial anatomy in young adults with evidence of coronary heart disease,'-" and angiographic studies have demonstrated less extensive coronary artery disease

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Section: Discussionmentioning

confidence: 99%

Myocardial infarction in young patients: an analysis by age subsets.

Hoit¹,

Gilpin²,

Henning³

et al. 1986

Circulation

198

104

View full text Add to dashboard Cite

show abstract

“…Coronary angiography (CAG) is a useful tool for diagnosing and evaluating the severity of coronary artery disease. A strong correlation between coronary risk factors and CAG findings has been established [20][21][22][23][24][25][26] . Although occupation categories can be surrogate measures for coronary risk factors, the relationship between taxi driving and severity of CHD, as determined angiographically, has not been investigated.…”

Section: Introductionmentioning

confidence: 90%

“…Industrial Health 2000, 38, [15][16][17][18][19][20][21][22][23] taxi drivers than in Japanese with other occupations [13][14][15][16][17][18][19] . Coronary angiography (CAG) is a useful tool for diagnosing and evaluating the severity of coronary artery disease.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Coronary Heart Disease in Japanese Taxi Drivers as Determined by Coronary Angiographic Analyses.

et al. 2000

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Several epidemiological studies have shown that the prevalence of ischemic heart disease is higher in occupational drivers than in people with other occupations. Although occupation categories can be surrogate measures for coronary risk factors, the relationships between taxi driving and severity of coronary heart disease (CHD) has not been investigated. Even more important, the contribution of risk factors to the severity of CHD in taxi drivers remains unclear. Our study tested the hypothesis that taxi driving could be associated with the severity of CHD. We also examined the relation between this occupation and risk factors and social lifestyle. We analyzed the coronary angiograms of 57 consecutive male taxi driver patients and compared them with those of 215 ageadjusted male non-taxi-driver patients. The number of diseased vessels and risk factors were compared between two groups. The prevalence of myocardial infarction and multi-vessel disease was higher in the taxi-driver patients than in the non-taxi-driver patients. The taxi-driver patients had higher prevalence of body mass index (BMI), diabetes, and smoking, higher levels of low-density lipoprotein cholesterol (LDL-C), and lower levels of apolipoprotein AI (ApoAI). Multiple logistic regression analysis showed that multi-vessel disease was associated with BMI and diabetes mellitus in taxi-driver patients. The taxi-driver patients were characterized by more extensive coronary atherosclerosis associated with higher prevalence of diabetes mellitus and obesity. These characteristics may be explained by in part their working environment.

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“…For the FA oxidation assay, the growth medium was removed, and the cell monolayers were washed three times with PBS. Next, HepG2 cells were lipid-loaded with DMEM containing 1.75 mM [1][2][3][4][5][6][7][8][9][10][11][12][13][14] C]palmitate (57 mCi/mM; Perkin Elmer) conjugated to 1 mg/ml FA-free BSA for 18 h. The medium was removed and centrifuged to remove cellular debris. It was then placed in a sealed container with a reservoir containing 0.5 ml of 1 M NaOH.…”

Section: Fa Oxidationmentioning

confidence: 99%

Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome

Jun

Lee

Kim

et al. 2014

Journal of Lipid Research

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This article is available online at http://www.jlr.org increase in the fasting TG level was associated with 14% and 37% higher incidences of CVD in men and women, respectively ( 3 ). A TG level reduction of the same magnitude could be achieved by dietary interventions, possibly based on the intake of fruits, vegetables, and teas ( 4, 5 ).The ingestion of fragrant herbal teas has been suggested as a simple and effective way of preventing CVD, with green tea being the most widely used ( 6 ). Studies on the hypolipidemic effects of teas have particularly focused on the catechins in green tea as potent active compounds ( 7,8 ). However, catechins alone cannot explain the lipid-lowering effects of teas because data on the effects of catechins in human trials have not been consistently positive ( 9, 10 ). The majority of human epidemiological and interventional studies have indicated benefi cial effects of catechin on metabolic syndrome ( 11 ). However, the number of human studies in this fi eld is still considered to be limited because some published clinical studies have shown that catechin has no effects on metabolic risk factors, including insulin sensitivity and secretion, as well as on glucose tolerance, cholesterol, and TG levels ( 10 ). In addition, noncatechin phytochemicals derived from teas have been reported to exert hypolipidemic effects independently or synergistically. In particular, teas are rich in fl avor compounds, among which the terpenoids could be potent, active compounds to enhance hepatic cholesterol and FA metabolism ( 12, 13 ). However, the metabolic functions of terpenoid aroma compounds in teas have largely been ignored. Hypertriglyceridemia is an independent risk factor in the development of CVD and a key component of metabolic syndrome ( 1, 2 ). A meta-analysis showed that a 1 mM

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Association of risk factor variables and coronary artery disease documented with angiography.

Cited by 106 publications

References 24 publications

Myocardial infarction in young patients: an analysis by age subsets.

Myocardial infarction in young patients: an analysis by age subsets.

Characteristics of Coronary Heart Disease in Japanese Taxi Drivers as Determined by Coronary Angiographic Analyses.

Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome

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