Association of rhinovirus species with common cold and asthma symptoms and bacterial pathogens

Bashir, Hiba; Grindle, Kristine; Vrtis, Rose F.; Vang, Fue; Kang, Teresa; Salazar, L.E.P.; Anderson, Elizabeth; Pappas, T.E.; Gangnon, Ronald E.; Evans, Michael D.; Jackson, Daniel J.; Lemanske, Robert F.; Bochkov, Yury A.; Gern, James E.

doi:10.1016/j.jaci.2017.09.027

Cited by 38 publications

(44 citation statements)

References 13 publications

(13 reference statements)

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“… 9 Furthermore, a recent analysis from RhinoGen study (310 children [aged 4-12 years] with or without asthma, using quantitative PCR for 3 bacteria) reported that RV-A and RV-C are differentially associated with increased quantity of H influenzae , M catarrhalis , and S pneumoniae . 7 Our observations—for example, the association between RV-C and higher likelihood of Moraxella -dominant microbiota— corroborate these earlier findings, and extend them by applying 16S rRNA gene sequencing to the airway samples of a large multicenter prospective cohort of infants with severe bronchiolitis.…”

supporting

confidence: 87%

“… 6 Recently, RV-A and RV-C were reported to differentially associate with detection of pathogenic bacteria in school-age children. 7 However, no study has investigated the relationships between rhinovirus species and airway microbiota in infants, let alone infants with bronchiolitis. To address the knowledge gap, we examined the association between rhinovirus species and the nasopharyngeal airway microbiota determined by 16S rRNA gene sequencing in 774 infants with severe bronchiolitis.…”

mentioning

confidence: 99%

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Association between rhinovirus species and nasopharyngeal microbiota in infants with severe bronchiolitis

Toivonen

Camargo

Gern

et al. 2019

Journal of Allergy and Clinical Immunology

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Complementing our previous introduction of human neutrophils as APCs in allergic LPR, the results presented here provide insights in their mechanisms of T-cell activation. Our findings indicate that neutrophils fully activate T cells by costimulation of CD2 with CD58 and promote T-cell-mediated inflammation. We conclude that neutrophils, which are recruited in high numbers to inflammatory sites, also contribute to allergic inflammatory diseases through the activation of allergen-specific T cells.

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supporting

confidence: 87%

mentioning

confidence: 99%

Association between rhinovirus species and nasopharyngeal microbiota in infants with severe bronchiolitis

Toivonen

Camargo

Gern

et al. 2019

Journal of Allergy and Clinical Immunology

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“…Asthmatic children tend to have overlapping symptoms of acute viral infections which lead to acute asthma exacerbations, the misdiagnosis or overtreatment of such cases with antibiotics may lead to drug-resistant organisms. 13 Therefore, parents should be well educated regarding the symptoms of asthma in their children and when to seek medical help.…”

Section: Discussionmentioning

confidence: 99%

<p>Childhood Asthma Awareness in Saudi Arabia: Five-Year Follow-Up Study</p>

Alharbi

Kobeisy

AlKhater

et al. 2020

JAA

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Background: Bronchial asthma is a chronic inflammatory airway disease that is characterized by reversible airway obstruction due to bronchial hyperresponsiveness. It is one of the most common chronic diseases. In Saudi Arabia, asthma affects 2 million people with asthma frequency in children markedly higher than adults with regional variations ranging from 9% to 33.7%. Objective: The aim of this study is to measure asthma awareness and knowledge of study participants during the ongoing annual Saudi asthma awareness campaigns and compare them with previous survey data conducted in 2014. Methods: A cross-sectional study was carried out in the form of a survey distributed across three major cities in Saudi Arabia, Jeddah, Riyadh and Dammam, during the National Asthma Awareness Campaign in major regional shopping centers in April 2019. Asthma knowledge scores across different demographic groups were generated from surveyed data. Descriptive and correlative statistical analyses were performed to identify factors associated with changes in asthma knowledge. Scores were compared to previous survey results. Results: The mean score for asthma knowledge was 15.6 out of 25. Asthma knowledge significantly correlated with age (P=0.002), asthma status of the participants (P=0.001), having children with asthma (P=0.005) or knowing friends or family with asthma (P=0.029) but not with other socioeconomic factors such as gender, marital status, occupation, level of education and number of children in the family (P > 0.05). There was a significant difference in the asthma scores from 2014 (M= 63%, SD=26) to 2019 (M= 70%, SD= 26) conditions; t (24) = −2.106, p=0.046. Conclusion: Further educational campaigns are necessary to enhance and measure general public awareness of asthma, its differential diagnosis against other respiratory infections, environmental triggers, risk factors as well as treatment options.

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“…This is mainly because the cold temperature in winter can stimulate the respiratory epithelial cells and induce airway hyper-responsiveness [27,28]. Cold temperature further aggravates the respiratory symptoms of primary asthma [29]. Chinese medicine advocate for "warming the lung to resolve uid" to treat cold asthma.…”

Section: Discussionmentioning

confidence: 99%

Winyanghuayin Decoction and Xiaoqinglong Decoction Treatment Airway Inflammation of Cold Asthma Through PI3K-mTOR Signal Pathway

Chang

Zhang

Qing-xiang

et al. 2020

Preprint

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Abstract Background: Airway inflammation plays a pivotal role in cold asthma. Winyanghuayin decoction and Xiaoqinglong decoction can significantly improve airway inflammation. The aim of the present study was to explore the therapeutic effect and mechanism of Winyanghuayin decoction and Xiaoqinglong decoction on OVA-induced cold asthma in rat and compare the effects of Winyanghuayin decoction and Xiaoqinglong decoction for treatment of cold asthma ratsMethods: The cold asthma rat model was induced by OVA and ice water swim stress, treated with Winyanghuayin decoction and Xiaoqinglong decoction respectively. The pulmonary function of asthmatic rats was detected by MIR Spirolab; The pathological changes of lung tissue were observed by HE staining; The autophagy in the lung of rats were observed by transmission electron microscopy; The eosinophils, lymphocytes, macrophages and total cells in bronchoalveolar lavage fluid (BALF) were counted under light microscope. The expression of IL-10\IL-13\TNF-α and TGF-β1 in serum were measured by enzyme-linked immunosorbent assay (ELISA); The protein level of LC3-II\I, ATG, PI3K and mTOR expression in lung tissues were detected by Western blot; Real-time polymerase chain reaction (RT-PCR) detected the expression of autophagy gene ATG3\ATG5\ATG7 and ATG12.Results: Winyanghuayin decoction and Xiaoqinglong decoction can alleviate airway inflammation and improve airway hyper-responsiveness, significantly increased the level of autophagy in lung tissue and decreased the protein level of PI3K and mTOR in lung tissue of cold asthma rats. Winyanghuayin decoction have better regulation ability on autophagy and PI3K-mTOR signaling pathway.Conclusion: Winyanghuayin decoction and Xiaoqinglong decoction may alleviate the airway inflammation symptoms by enhancing autophagy in lung tissue dependent on the PI3K-mTOR signaling pathway. Winyanghuayin decoction was more effective than Xiaoqinglong decoction for treatment of cold asthma.

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Association of rhinovirus species with common cold and asthma symptoms and bacterial pathogens

Cited by 38 publications

References 13 publications

Association between rhinovirus species and nasopharyngeal microbiota in infants with severe bronchiolitis

Association between rhinovirus species and nasopharyngeal microbiota in infants with severe bronchiolitis

<p>Childhood Asthma Awareness in Saudi Arabia: Five-Year Follow-Up Study</p>

Winyanghuayin Decoction and Xiaoqinglong Decoction Treatment Airway Inflammation of Cold Asthma Through PI3K-mTOR Signal Pathway

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