Association between rhinovirus species and nasopharyngeal microbiota in infants with severe bronchiolitis

Toivonen, Laura; Camargo, Carlos A.; Gern, James E.; Bochkov, Yury A.; Mansbach, Jonathan M.; Piedra, Pedro A.; Hasegawa, Kohei

doi:10.1016/j.jaci.2018.12.1004

Cited by 26 publications

(51 citation statements)

References 26 publications

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“…Although bronchiolitis has been conventionally considered a single disease entity that has similar mechanisms and clinical characteristics (8), concordant with the current study, recent studies demonstrate important between-virus (respiratory syncytial virus vs. rhinovirus, including different species) differences in the upper airway metabolome (9,13) and microbiome (14,15) profiles. The current study corroborates these prior reports, and extends them by demonstrating between-CoV differences in these molecular characteristics among infants with severe bronchiolitis.…”

Section: Discussionsupporting

confidence: 85%

Association of endemic coronaviruses with nasopharyngeal metabolome and microbiota among infants with severe bronchiolitis: a prospective multicenter study

et al. 2020

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Section: Discussionsupporting

confidence: 85%

Association of endemic coronaviruses with nasopharyngeal metabolome and microbiota among infants with severe bronchiolitis: a prospective multicenter study

et al. 2020

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“…found that the nasopharyngeal microbiota influenced infection by different rhinovirus species. 51 Infants with a predominant Haemophilus microbiota profile were more likely to have infection by rhinovirus-A species, whereas infants with a predominant Moraxella microbiota profile were more likely to have infection by rhinovirus-C species. 51 Mansbach et al.…”

Section: The Nasal Microbiomementioning

confidence: 94%

The Microbiome of the Nose—Friend or Foe?

Dimitri-Pinheiro

Soares

Barata

2020

Allergy�Rhinol (Providence)

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Recently, multiple studies regarding the human microbiota and its role on the development of disease have emerged. Current research suggests that the nasal cavity is a major reservoir for opportunistic pathogens, which can then spread to other sections of the respiratory tract and be involved in the development of conditions such as allergic rhinitis, chronic rhinosinusitis, asthma, pneumonia, and otitis media. However, our knowledge of how nasal microbiota changes originate nasopharyngeal and respiratory conditions is still incipient. Herein, we describe how the nasal microbiome in healthy individuals varies with age and explore the effect of nasal microbiota changes in a range of infectious and immunological conditions. We also describe the potential health benefits of human microbiota modulation through probiotic use, both in disease prevention and as adjuvant therapy. Current research suggests that patients with different chronic rhinosinusitis phenotypes possess distinct nasal microbiota profiles, which influence immune response and may be used in the future as biomarkers of disease progression. Probiotic intervention may also have a promising role in the prevention and adjunctive treatment of acute respiratory tract infections and allergic rhinitis, respectively. However, further studies are needed to define the role of probiotics in the chronic rhinosinusitis.

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“…We analyzed data from the 35th Multicenter Airway Research Collaboration (MARC‐35)—a multicenter prospective cohort study of infants hospitalized with bronchiolitis 6‐13,15,16 . Site investigators enrolled infants (age of <1 year) hospitalized with bronchiolitis at 17 sites across 14 US states (Table ) during three consecutive bronchiolitis seasons (from November through April) in 2011‐2014.…”

Section: Methodsmentioning

confidence: 99%

Respiratory viruses are associated with serum metabolome among infants hospitalized for bronchiolitis: A multicenter study

Fujiogi

Camargo

Raita

et al. 2020

Pediatric Allergy Immunology

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Background: Bronchiolitis is the leading cause of infant hospitalizations in the United States. Growing evidence supports the heterogeneity of bronchiolitis. However, little is known about the interrelationships between major respiratory viruses (and their species), host systemic metabolism, and disease pathobiology. Methods: In an ongoing multicenter prospective cohort study, we profiled the serum metabolome in 113 infants (63 RSV-only, 21 RV-A, and 29 RV-C) hospitalized with bronchiolitis. We identified serum metabolites that are most discriminatory in the RSV-RV-A and RSV-RV-C comparisons using sparse partial least squares discriminant analysis. We then investigated the association between discriminatory metabolites with acute and chronic outcomes. Results: In 113 infants with bronchiolitis, we measured 639 metabolites. Serum metabolomic profiles differed in both comparisons (P permutation < 0.05). In the RSV-RV-A comparison, we identified 30 discriminatory metabolites, predominantly in lipid metabolism pathways (eg, sphingolipids and carnitines). In multivariable models, these metabolites were significantly associated with the risk of clinical outcomes (eg, tricosanoyl sphingomyelin, OR for recurrent wheezing at age of 3 years = 1.50; 95% CI: 1.05-2.15). In the RSV-RV-C comparison, the discriminatory metabolites were also primarily involved in lipid metabolism (eg, glycerophosphocholines [GPCs], 12,13-diHome). These metabolites were also significantly associated with the risk of outcomes (eg, 1-stearoyl-2-linoleoyl-GPC, OR for positive pressure ventilation use during hospitalization = 0.47; 95% CI: 0.28-0.78). Conclusion: Respiratory viruses and their species had distinct serum metabolomic signatures that are associated with differential risks of acute and chronic morbidities of bronchiolitis. Our findings advance research into the complex interrelations between viruses, host systemic response, and bronchiolitis pathobiology.

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Association between rhinovirus species and nasopharyngeal microbiota in infants with severe bronchiolitis

Cited by 26 publications

References 26 publications

Association of endemic coronaviruses with nasopharyngeal metabolome and microbiota among infants with severe bronchiolitis: a prospective multicenter study

Association of endemic coronaviruses with nasopharyngeal metabolome and microbiota among infants with severe bronchiolitis: a prospective multicenter study

The Microbiome of the Nose—Friend or Foe?

Respiratory viruses are associated with serum metabolome among infants hospitalized for bronchiolitis: A multicenter study

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