2023
DOI: 10.1053/j.ajkd.2022.09.018
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Association of Retinal Age Gap and Risk of Kidney Failure: A UK Biobank Study

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Cited by 24 publications
(17 citation statements)
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“…Moreover, this approach is particularly effective with small data sets, such as OCT and OCTA, where it can achieve strong performance. Besides, it is worth noting that certain DL methods can also be leveraged to extract retinal characteristic biomarkers to aid in disease diagnosis and prediction 46–49 …”
Section: Two Research Patterns For Analyzing Ocular Datamentioning
confidence: 99%
See 1 more Smart Citation
“…Moreover, this approach is particularly effective with small data sets, such as OCT and OCTA, where it can achieve strong performance. Besides, it is worth noting that certain DL methods can also be leveraged to extract retinal characteristic biomarkers to aid in disease diagnosis and prediction 46–49 …”
Section: Two Research Patterns For Analyzing Ocular Datamentioning
confidence: 99%
“…The associations between the retinal age gap and the risk of kidney disease were subsequently evaluated. The findings indicated that there was a significant association between the retinal age gap and the risk of developing kidney failure, with each additional year of retinal age gap contributing to a 10% increase in the risk of incident kidney failure independently (HR = 1.10) 46 . While the retinal age gap biomarker has demonstrated excellent performance in identifying various systemic diseases, the absence of specific analysis and differentiation between these diseases may limit its practical application in real clinical settings.…”
Section: Application Of Ai Using Ocular Images For Systemic Diseases ...mentioning
confidence: 99%
“…Longitudinal studies showed the retinal age gap independently predicted the risk for all-cause and cause-specific mortality 208,212 and age-related morbidities, including neurodegenerative disease, 215 cardiovascular diseases, 208,216 and kidney failure. 217…”
Section: Retinal Agementioning
confidence: 99%
“…And the incidence of CKD or advanced CKD in high‐risk groups was significantly different from medium‐risk groups, while no differences were observed in low‐risk groups of CKD ( p = 0.212 and 0.689 in the internal and external longitudinal test sets, respectively). A DL model was developed by Zhang et al 100 . to characterize retinal age from retinal images and the retinal age gap (difference between model‐based retinal age and chronological age) was used to predict the risk of ESRD.…”
Section: Guiding Treatment and Predicting Prognosis From Retinal Imagingmentioning
confidence: 99%
“…And the incidence of CKD or advanced CKD in high-risk groups was significantly different from medium-risk groups, while no differences were observed in low-risk groups of CKD (p = 0.212 and 0.689 in the internal and external longitudinal test sets, respectively). A DL model was developed by Zhang et al 100 increase in the risk of incident ESRD with each one-year increase in retinal age gap (HR = 1.10, 95% CI: 1.03-1.17).…”
Section: Predicting the Prognosis And Mortality Of Ckdmentioning
confidence: 99%