Association of Restless Legs Syndrome in Type 2 Diabetes: A Case-Control Study

Merlino, Giovanni; Fratticci, Lara; Valente, Mariarosaria; Giudice, Angela Del; Noacco, Claudio; Dolso, Pierluigi; Cancelli, Iacopo; Scalise, Anna; Gigli, Gian Luigi

doi:10.1093/sleep/30.7.866

Cited by 144 publications

(131 citation statements)

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“…In this context, results from several crosssectional studies suggest an association of RLS with chronic kidney disease and cardiovascular diseases [4][5][6][7]. Secondary RLS in chronic kidney disease is frequently called "uremic RLS" [7].…”

Section: Introductionmentioning

confidence: 99%

Restless legs syndrome does not affect 3-year mortality in hemodialysis patients

et al. 2015

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Original Highlights of the studyWe evaluated the relationship of RLS and mortality in chronic hemodialysis patients For the diagnosis of RLS we implemented standard methodology, i.e. the essential clinical criteria of the International RLS Study Group. This is the first time this issue is investigated in an epidemiological survey in Greece.In contrast to previous reports the diagnosis of RLS does not influence the 3-year mortality in HD patients. ABSTRACTObjective: In chronic hemodialysis (HD) patients, the prevalence of restless legs syndrome (RLS) is significantly higher than in the general population. Uremic RLS has been related to an enhanced mortality of HD patients. In the general population, however, studies of this association have yielded inconsistent results. The aim of the present study was to re-evaluate the relationship of RLS and mortality in HD patients. Methods:We recorded the 3-year mortality rate in a population of 579 HD patients after assessment for RLS symptoms. In addition we analyzed the 5-year mortality rate after end-stage renal disease onset (i.e., commencement of HD). This HD patient population has been previously included in a cross-sectional survey of RLS prevalence in which RLS diagnosis was based on the essential clinical criteria of the International RLS Study Group. Mortality data were acquired from the national endstage renal disease registry. Survival probability was calculated by means of the Kaplan-Meier method and analyzed by the log-rank (Mantel-Cox) test. For multivariate survival analysis, we implemented a proportional hazards regression Conclusion: Diagnosis of RLS according to the essential clinical criteria of theInternational RLS Study Group does not seem to influence the 3-year mortality in HD patients. Our findings are in contrast to those in some previous reports, and reinforce the need for further studies of RLS and mortality in HD patients.

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Section: Introductionmentioning

confidence: 99%

Restless legs syndrome does not affect 3-year mortality in hemodialysis patients

et al. 2015

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“…sergančiųjų CD patiria epilepsinius priepuolius [20]. Sergant CD, gali pasireikšti chorėja-balizmas, neramių kojų sindromas [21,22].…”

Section: įVadasunclassified

“…kontrolinės grupės asmenims; NKS buvo susijęs su 2 tipo CD; polineuropatija diagnozuota 27 proc. diabetikų su NKS; ši studija patvirtino ryšį tarp NKS ir 2 tipo CD [22]. Mūsų tyrimo duomenimis, NKS pasireiškė keturiems (3,9 proc.)…”

Section: Rezultatų Aptarimasunclassified

Neurologinė Patologija Sergant 2 Tipo Cukriniu Diabetu

Kimševaitė¹

2017

Medicinos Teorija Ir Praktika

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Vilniaus miesto klinikinė ligoninė Vilnius City Clinical Hospital SANTRAUKAReikšminiai žodžiai: cukrinis diabetas, neurologinė patologija, neurologinės komplikacijos. Darbo tikslas. Išanalizuoti 2 tipo cukriniu diabetu sergančių asmenų neurologinę patologiją. Tyrimo medžiaga ir metodai. Vilniaus miesto klinikinės ligoninės Vidaus ligų, Nefrologijos, I ir II angiochirurgijos, Urologijos skyriuose 2015 m. rugpjūtį -2016 m. birželį tyrėme 102 2 tipo cukriniu diabetu sergančius ligonius (80 moterų ir 22 vyrus), kuriems buvo ar pasireiškė neurologinė patologija. Ligonių amžius 49-92 metai (vidurkis 73,2 ± 1,1 metų). Visiems ligoniams atliktas bendras kraujo tyrimas, nustatyta gliukozės koncentracija kraujo serume, glikozilintas hemoglobinas HbA1C, atlikta vidaus organų echoskopija, daliai ligonių -pilvo organų kompiuterinė tomografija (KT), esant indikacijoms -galvos (stuburo) KT, magnetinio rezonanso tomografija (MRT). Statistinių duomenų vidurkių skirtumai vertinti Stjudento patikimumo kriterijumi t. Skirtumai laikyti statistiškai patikimi esant p < 0,05. Rezultatai. Išanalizuota sergančiųjų 2 tipo cukriniu diabetu neurologinė patologija. Galvos smegenų kraujotakos sutrikimai buvo 23 (22,5 proc.) ligoniams, diabetinė encefalopatija -4 (3,9 proc.), diabetinė koma -1 (1 proc.), hipoglikeminė koma -1 (1 proc.), lėtinė galvos smegenų išemija -10 (9,8 proc.), epilepsiniai priepuoliai -3 (2,9 proc.), Parkinsono liga -3 (2,9 proc.), diabetinė chorėja -1 (1 proc.), diabetinė mielopatija -1 (1 proc.), diabetinė periferinė neuropatija -46 (45,1 proc.), diabetinė autonominė neuropatija -3(2,9 proc.), peties rezginio neuropatija (plexopathia brachialis) -1 (1 proc.), veidinio nervo neuropatija -2 (2 proc.), vidurinio nervo neuropatija -1 (1 proc.), meralgia paraesthetica -2 (2 proc.). Galvos smegenų infarkto atveju, palyginus su sergančiųjų lėtine galvos smegenų išemija grupe, nustatyta statistiškai patikimai didesnė hiperglikemija: ženkliai padidėjęs gliukozės (11,08 ± 1,3 mmol/l, p < 0,02), glikozilinto hemoglobino HbA1C (8,5 ± 1,2 proc., p < 0,05) kiekis kraujyje. Lėtine galvos smegenų išemija sergančiųjų grupėje gliukozės kiekis kraujyje buvo 7,26 ± 0,4 mmol/l, glikozilinto hemoglobino HbA1C -6,03 ± 0,2 proc. Padidėjęs gliukozės, glikozilinto hemoglobino HbA1C kiekis kraujyje, palyginus su sergančiųjų lėtine galvos smegenų išemija grupe, nustatytas ir praeityje galvos smegenų infarktą patyrusiems ligoniams -atitinkamai 8,65 ± 0,7 mmol/l ir 7,26 ± 0,4 mmol/l (p > 0,05), 7,2 ± 0,4 proc. ir 6,03 ± 0,2 proc. (p < 0,01). Nustatyta sergančiųjų diabetine polineuropatija hiperglikemijos dydžio priklausomybė nuo cukrinio diabeto trukmės: sergančiųjų cukriniu diabetu daugiau kaip 10 metų, palyginus su sergančiųjų iki 5 metų grupe, gliukozės kiekis kraujyje buvo atitinkamai 9,93 ± 0,8 mmol/l ir 7,6 ± 0,7 mmol/l (p < 0,05), glikozilinto hemoglobino HbA1C -8,2 ± 0,3 proc. ir 5,78 ± 0,1 proc. (p < 0,001). Sergančiųjų cukriniu diabetu nuo 5 iki 10 metų gliukozės kiekis kraujyje buvo 8,3 ± 1,0 mmol/l, (p > 0,05), glikozilinto hemoglobino ...

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“…[89][90][91][92][93] An imbalanced equilibrium in the dorsal horn of the spinal grey matter among the excitatory nociceptive inputs, due to the peripheral neuropathy, and the inhibitory ones descending from the diencephalon might explain the occurrence of RLS in the course of peripheral neuropathy. 33 Differently from primary RLS, patients affected by RLS due to polyneuropathy identify the sensory discomfort in the legs as painful sensations.…”

Section: Vesper's Cursementioning

confidence: 99%

“…32 Recently, type 2 diabetes mellitus and multiple sclerosis have been recognized as being able to favor RLS. 33,34 Patients affected by secondary forms of the sleep disorder report a low frequency of positive family history of RLS, a late age of onset of RLS, and the antecedence of onset of the main clinical condition to RLS onset. In addition, a treatment able to remove the main clinical condition (such as iron supplements and kidney transplantation) may produce a complete remission of RLS symptomatology.…”

Section: Introductionmentioning

confidence: 99%

Restless legs syndrome: differential diagnosis and management with rotigotine

Merlino

Serafini²,

Robiony³

et al. 2009

NDT

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RLS is a common sleep disorder with distinctive clinical features. The prevalence of RLS in Caucasians and North Americans ranges from 5% to 10%. However, only some of these subjects (almost the 3% of the general population) report being affected by a frequent and severe form of the sleep disorder. RLS is diagnosed clinically by means of four internationally recognized criteria that summarize the main characteristics of the sleep disorder. Besides the essential criteria, supportive and associated features of RLS have been established by experts in order to help physicians treat patients with doubtful symptoms. Several clinical conditions may mimic this sleep disorder. In order to increase the sensibility and specifi city of RLS diagnosis, doctors should perform a meticulous patient history and then an accurate physical and neurological examination. Dopamine agonists are recognized as the preferred fi rst-line treatment for RLS. Rotigotine is a non-ergoline dopamine agonist with selectivity for D1, D2 and D3 receptors. The drug is administered via transdermal patches which release rotigotine for 24 hours. Four clinical trials demonstrated that this compound is able to improve RLS symptomatology with few and moderate adverse events. Head to head trials are required to compare the effi cacy and tolerability of rotigotine with other dopamine agonists administered via oral intake. Rotigotine has been approved by the FDA and EMEA for Parkinson's disease. For the treatment of moderate to severe idiopathic RLS, rotigotine has been recommended for approval by the EMEA and is under review by the FDA.

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Association of Restless Legs Syndrome in Type 2 Diabetes: A Case-Control Study

Cited by 144 publications

References 30 publications

Restless legs syndrome does not affect 3-year mortality in hemodialysis patients

Restless legs syndrome does not affect 3-year mortality in hemodialysis patients

Neurologinė Patologija Sergant 2 Tipo Cukriniu Diabetu

Restless legs syndrome: differential diagnosis and management with rotigotine

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