Association of resistin polymorphisms with resistin levels and lipid profile in children

Ortega, Lorena; Navarro, Pilar; Riestra, Pía; Gavela-Pérez, Teresa; Soriano‐Guillén, Leandro; Garcés, Cármen

doi:10.1007/s11033-014-3658-8

Cited by 14 publications

(12 citation statements)

References 36 publications

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“…Some studies have confirmed the relationship between rs1862513 SNP, an expression of inflammatory molecules, and adipokines [10,11,35]. Our results did not show any association between basal or post-treatment adipokine serum levels and this RETN variant.…”

Section: Discussioncontrasting

confidence: 45%

The rs1862513 Variant in Resistin Gene-Modified Insulin Resistance and Insulin Levels after Weight Loss Secondary to Hypocaloric Diet

Luis¹,

Izaola²,

Primo³

et al. 2016

Ann Nutr Metab

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Background/Aims: Polymorphisms of a single nucleotide in RETN have been associated with indexes of insulin resistance. Our aim was to analyze the effects of the rs1862513 RETN gene polymorphism on insulin resistance, insulin levels, and resistin levels changes after 3 months of a low-fat hypocaloric diet. Design: A Caucasian population of 133 obese patients was analyzed before and after 3 months on a low-fat hypocaloric diet. Results: Fifty-six patients (42.1%) had the genotype GG (wild group) and 77 (57.9%) patients had the other genotypes; GC (59 patients, 44.4%) or CC (18 patients, 13.5%; mutant group). In wild and mutant genotype groups, weight, body mass index, fat mass, waist circumference, and systolic blood pressure decreased. In the wild genotype group, the decrease in total cholesterol was -13.1 ± 25.3 mg/dL (vs. -4.4 ± 13.7 mg/dL in mutant group: p = 0.004 for group deltas), low density lipoprotein (LDL)-cholesterol was -13.0 ± 21.5 mg/dL (-4.3 ± 10.5 mg/dL: p = 0.007), glucose -7.2 ± 3.5 mg/dL (-0.8 ± 0.2 mg/dL: p = 0.01), insulin -5.6 ± 2.5 mUI/L (-2.9 ± 1.2 mUI/L: p = 0.03) and homeostasis model assessment-insulin resistance (HOMA-IR) -2.5 ± 1.1 (-0.6 ± 1.4: p = 0.02). Leptin levels decreased in both genotypes (-10.1 ± 9.5 ng/dL in wild type group vs. -13.1 ± 0.2 ng/dL in mutant type group: p > 0.05). Conclusion: The present study suggests that the G/G genotype of RETN rs1862513 could be a predictor of the reduction of HOMA-IR, insulin, fasting glucose and LDL cholesterol secondary to a hypocaloric diet in obese subjects.

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Section: Discussioncontrasting

confidence: 45%

The rs1862513 Variant in Resistin Gene-Modified Insulin Resistance and Insulin Levels after Weight Loss Secondary to Hypocaloric Diet

Luis¹,

Izaola²,

Primo³

et al. 2016

Ann Nutr Metab

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“…However, in contrast to Ukkola et al and Qi et al, they found the relation with serum resistin concentrations to be inverse for the alleles [77,85,89]. A relationship between rs10401670 and serum resistin levels could be detected in 6-to 8-year-old boys ( Table 1) [90].…”

Section: Resistin (Retn)mentioning

confidence: 65%

Genetic Determination of Serum Levels of Diabetes-Associated Adipokines

Schleinitz

2015

Rev Diabet Stud

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■ AbstractAdipose tissue secretes an abundance of proteins. Some of these proteins are known as adipokines and adipose-derived hormones which have been linked with metabolic disorders, including type 2 diabetes, and even with cancer. Variance in serum adipokine concentration is often closely associated with an increase (obesity) or decrease (lipodystrophy) in fat tissue mass, and it is affected by age, gender, and localization of the adipose tissue. However, there may be genetic variants which, in consequence, influence the serum concentration of a certain adipokine, and thereby promote metabolic disturbances or, with regard to the "protective" allele, exert beneficial effects. This review focuses on the genetic determination of serum levels of the following adipokines: adiponectin, chemerin, leptin, progranulin, resistin, retinol binding protein 4, vaspin, adipsin, apelin, and omentin. The article reports on the latest findings from genome-wide association studies (GWAS) and candidate gene studies, showing variants located in/nearby the adipokine genes and other (non-receptor) genes. An extra chapter highlights adipokine-receptor variants. Epigenetic studies on adipokines are also addressed.

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“…Hivert et al found that the SNP rs10401670 was associated with serum resistin and fasting plasma glucose levels [15]. Similarly, a study of 1269 children by Ortega et al revealed that the SNP rs10401670 was not only associated with resistin levels, but also related to TC and low-density lipoprotein [14]. These results reveal that rs10401670 is closed related to human metabolism.…”

Section: Resistin May Mediate Tumor Initiation and Progression In A Vmentioning

confidence: 95%

“…Resistin, an adipokine that consists of 108 amino acids with a molecular weight of 12.5 kDa, is mainly secreted by monocytes and macrophages [12]. Since the discovery of resistin in 2001, research has focused on its role in obesity, lipid metabolism, and diabetes [13][14][15]. Latest studies indicate that resistin functions in tumor development across multiple systems.…”

Section: Introductionmentioning

confidence: 99%

The role of resistin gene polymorphisms in bladder cancer

Deng¹,

He²,

Zhao³

et al. 2020

Preprint

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Background: Published studies have demonstrated that resistin, a recently discovered adipokine, is connected to insulin resistance, type 2 diabetes mellitus, obesity, inflammation, and atherosclerotic vascular disease. A comprehensive study of the adipocytokine family and tumor pathogenesis indicates an intimate relationship between resistin and the incidence, progression, and metastasis of gastric cancer, esophageal cancer, choriocarcinoma, colorectal cancer, pancreatic cancer, and biliary tract cancer. To date, the connection between resistin and bladder cancer has not been thoroughly investigated and remains unclear. Methods: Overall, 322 patients with bladder cancer and 366 normal controls were included in the study. Two SNPs of the resistin gene, rs1862513 (also known as −420 C/G) and rs10401670 (3’UTR C/T) were genotyped across the entire cohort. Next, the association between the two SNPs and the incidence, risk factors, and prognosis of bladder cancer, were analyzed. Results: The frequency of T allele and CT/TT genotype of rs10401670 was significantly lower in bladder cancer patients (P=0.03, OR=0.79 and P = 0.018, OR = 0.68, respectively) compared to normal controls. No differences were found with regards to the rs1862513 genotype frequency and the distribution of allele frequency between the two groups. Stratified analyses showed that the CT heterozygous genotype of rs10401670 was associated with bladder cancer at an earlier age (OR=1.97, 95% CI=1.14–3.40) and the CG heterozygous genotype of rs1862513 was correlated with high incidence of bladder cancer in smokers (OR=1.73, 95 % CI=1.05–2.87). Multiple Cox regression analysis showed that for bladder cancer patients, the presence of a CG heterozygous genotype of rs1862513 was associated with a decrease in the risk of recurrence in MIBC patients (P = 0.04，OR= 0.49). Additionally, the rs1040167 CT/TT genotype (P = 0.03，OR= 2.45), especially the TT homozygous genotype (P = 0.02，OR= 3.00) was associated with high risk of death. These results indicate that the rs1040167 CT/TT and TT homozygous genotype may be a risk factor for overall survival of bladder cancer patients. Conclusions: Our results suggest that resistin genotype serves as a risk factors for the occurrence and prognosis of bladder cancer, and could be be a potential biomarker for this devastating disease.

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Association of resistin polymorphisms with resistin levels and lipid profile in children

Cited by 14 publications

References 36 publications

The rs1862513 Variant in Resistin Gene-Modified Insulin Resistance and Insulin Levels after Weight Loss Secondary to Hypocaloric Diet

The rs1862513 Variant in Resistin Gene-Modified Insulin Resistance and Insulin Levels after Weight Loss Secondary to Hypocaloric Diet

Genetic Determination of Serum Levels of Diabetes-Associated Adipokines

The role of resistin gene polymorphisms in bladder cancer

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