Genetic Determination of Serum Levels of Diabetes-Associated Adipokines

Schleinitz, Dorit

doi:10.1900/rds.2015.12.277

Cited by 11 publications

(10 citation statements)

References 187 publications

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“…It was also shown that the reactive centre loop (RCL) is flexible and located between G364 and P381. Unfortunately, the mechanism of action was not established, but it was shown that the most likely target for vaspin is the kallikrein-related peptidase 7 (hK7) [35,36]. The physiological functions of the vaspin target are diverse.…”

Section: Adipokinesmentioning

confidence: 99%

The roles of vaspin, chemerin, and omentin in the determination of metabolic syndrome

Suliga¹,

Wawszczak²,

Głuszek³

2018

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Metabolic syndrome (MetS) is defined as multiple risk factors including abdominal obesity, dyslipidaemia, abnormal glycaemia, and elevated blood pressure. The incidence of MetS and pathophysiological mechanisms underlying its development are still not fully understood. It is thought that the occurrence of MetS arises from the complex relationship between genetic and environmental factors. The aim of the study was to overview and summarise current knowledge regarding genetic determinants of MetS. Also analysed were the relationship between polymorphisms of the genes encoding selected adipokines (vaspin, chemerin, omentin) and the risk of MetS, as well as other metabolic disorders. The precise determination of MetS genotype is difficult because metabolic syndrome occurrence is a combination of multiple risk factors. A thorough understanding of pathomechanisms of MetS, involving selected adipokines, may in the future allow the use of these adipokines as potential biomarkers of metabolic disorder risk.

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Section: Adipokinesmentioning

confidence: 99%

The roles of vaspin, chemerin, and omentin in the determination of metabolic syndrome

Suliga¹,

Wawszczak²,

Głuszek³

2018

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“…Adipokiny (adipocytokiny) to białkowe substancje bioaktywne, wytwarzane przez adipocyty, komórki zrębu naczyniowego, komórki śródbłonka, pericyty, komórki prekursorowe tkanki tłuszczowej czy komórki układu odpornościowego [1,2,4,8].…”

Section: Adipokinyunclassified

“…Zaburzenie syntezy niektórych adipokin, np. leptyny, TNF-α, IL-6 czy rezystyny wiąże się z zapoczątkowaniem procesu kancerogenezy [8,14]. Inne adipokiny, jak np.…”

Section: Adipokinyunclassified

Omentin – a novel biomarker in medicine? (Part 1)

Waluga¹,

Komosińska-Vassev²,

Szczepański³

et al. 2018

Farm Pol.

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“…In obesity, accumulated fat tissue, depending on the current metabolic status, is characterized by a different secretory profile [ 2 , 3 ]. Among the recently identified regulatory peptides secreted by both adipose tissue and peripheral organs (mainly liver and skeletal muscle), which play an important role in the pathogenesis of metabolic changes in the course of obesity associated with type 2 diabetes, adropin, irisin, and vaspin play an important role [ 4 , 5 , 6 , 7 , 8 ]. The first of them, adropin , is a secreted peptide translated from the Energy Homeostasis Associated ( ENHO ) gene linked to metabolic control.…”

Section: Introductionmentioning

confidence: 99%

The Usefulness of Diagnostic Panels Based on Circulating Adipocytokines/Regulatory Peptides, Renal Function Tests, Insulin Resistance Indicators and Lipid-Carbohydrate Metabolism Parameters in Diagnosis and Prognosis of Type 2 Diabetes Mellitus with Obesity

et al. 2020

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The quantitative analysis of selected regulatory molecules, i.e., adropin, irisin, and vaspin in the plasma of obese patients with newly diagnosed, untreated type 2 diabetes mellitus, and in the same patients after six months of using metformin, in relation to adropinemia, irisinemia and vaspinemia in obese individuals, was performed. The relationship between plasma concentration of the adipocytokines/regulatory peptides and parameters of renal function (albumin/creatinine ratio—ACR, estimated glomerular filtration rate—eGFR), values of insulin resistance indicators (Homeostatic Model Assessment of Insulin Resistance (HOMA-IR2), Homeostatic Model Assessment of Insulin Sensitivity (HOMA-S), Homeostatic Model Assessment of β-cell function (HOMA-B), quantitative insulin sensitivity check index (QUICKI), insulin), and parameters of carbohydrate-lipid metabolism (fasting plasma glucose—FPG, glycated hemoglobin—HbA1C, estimated glucose disposal rate—eGDR, fasting lipid profile, TG/HDL ratio) in obese type 2 diabetic patients was also investigated. Circulating irisin and vaspin were found significantly different in subjects with metabolically healthy obesity and in type 2 diabetic patients. Significant increases in blood levels of both analyzed adipokines/regulatory peptides were observed in diabetic patients after six months of metformin treatment, as compared to pre-treatment levels. The change in plasma vaspin level in response to metformin therapy was parallel with the improving of insulin resistance/sensitivity parameters. An attempt was made to identify a set of biochemical tests that would vary greatly in obese non-diabetic subjects and obese patients with type 2 diabetes, as well as a set of parameters that are changing in patients with type 2 diabetes under the influence of six months metformin therapy, and thus differentiating patients′ metabolic state before and after treatment. For these data analyses, both statistical measures of strength of the relationships of individual parameters, as well as multidimensional methods, including discriminant analysis and multifactorial analysis derived from machine learning methods, were used. Adropin, irisin, and vaspin were found as promising regulatory molecules, which may turn out to be useful indicators in the early detection of T2DM and differentiating the obesity phenotype with normal metabolic profile from T2DM obese patients. Multifactorial discriminant analysis revealed that irisin and vaspin plasma levels contribute clinically relevant information concerning the effectiveness of metformin treatment in T2D patients. Among the sets of variables differentiating with the highest accuracy the metabolic state of patients before and after six-month metformin treatment, were: (1) vaspin, HbA1c, HDL, LDL, TG, insulin, and HOMA-B (ACC = 88 [%]); (2) vaspin, irisin, QUICKI, and eGDR (ACC = 86 [%]); as well as, (3) vaspin, irisin, LDL, HOMA-S, ACR, and eGFR (ACC = 86 [%]).

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Genetic Determination of Serum Levels of Diabetes-Associated Adipokines

Cited by 11 publications

References 187 publications

The roles of vaspin, chemerin, and omentin in the determination of metabolic syndrome

The roles of vaspin, chemerin, and omentin in the determination of metabolic syndrome

Omentin – a novel biomarker in medicine? (Part 1)

The Usefulness of Diagnostic Panels Based on Circulating Adipocytokines/Regulatory Peptides, Renal Function Tests, Insulin Resistance Indicators and Lipid-Carbohydrate Metabolism Parameters in Diagnosis and Prognosis of Type 2 Diabetes Mellitus with Obesity

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