Association of renin-angiotensin system and natriuretic peptide receptor A gene polymorphisms with hypertension in a Hellenic population

Tsezou, Aspasia; Karayannis, Georgios; Giannatou, Eirini; Papanikolaou, Vasilis K.; Triposkiadis, Filippos

doi:10.1177/1470320308096412

Cited by 12 publications

(11 citation statements)

References 32 publications

(33 reference statements)

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“…Still, in the whole patient group this influence was not independent from common risk factors for atherosclerosis such as age, hypertension, smoking, and HDLC, similarly to the other study. 32 However, we found statistically a significant independent influence of DD genotype on plaque presence in the normotensive subgroup of patients. We previously showed that D allele was associated with hypertension in males in the Serb population.…”

Section: Discussioncontrasting

confidence: 50%

The association of ACE I/D gene polymorphism with severe carotid atherosclerosis in patients undergoing carotid endarterectomy

Kolaković

Živković

Radak

et al. 2011

J Renin Angiotensin Aldosterone Syst

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Introduction:The ACE I/D polymorphism was mostly investigated in association with intima-media thickness, rarely with severe atherosclerotic phenotype. Materials and methods:We investigated the association of I/D polymorphism with severe carotid atherosclerosis (CA) (stenosis > 70%) in asymptomatic and symptomatic patients undergoing carotid endarterectomy. The 504 patients subjected to endarterectomy and 492 healthy controls from a population in Serbia were investigated as a case-control study. Results:The univariate logistic regression analysis revealed ACE DD as a significant risk factor for severe CA (odds ratio [OR] = 1.3, 95% confidence interval [CI] 1.0-1.7, p = 0.04). After adjustment for the common risk factors (age, hypertension, smoking, and HDL) ACE was no longer significant. However, we found a significant independent influence of DD genotype on plaque presence in a normotensive subgroup of patients (OR 1.8, CI 1.2-3.0, p = 0.01, corrected for multiple testing). In symptomatic patients D allele carriers were significantly more frequent compared with asymptomatic patients (OR 1.6 CI 1.0-2.6, p = 0.05). Conclusions: Our data suggests that ACE I/D is not an independent risk factor for severe CA. On the other hand, a significant independent genetic influence of ACE I/D appeared in normotensive and symptomatic patients with severe CA. This should be considered in further research toward resolving the complex genetic background of severe CA phenotype.

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Section: Discussioncontrasting

confidence: 50%

The association of ACE I/D gene polymorphism with severe carotid atherosclerosis in patients undergoing carotid endarterectomy

Kolaković

Živković

Radak

et al. 2011

J Renin Angiotensin Aldosterone Syst

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“…In recent years, a series of genes have been proposed to influence the mechanism of blood pressure. Some evidences of association between these genes had been reported [4–6] but on the contrary these associations were not always significant [7]. …”

Section: Introductionmentioning

confidence: 99%

Gender Specific Association of RAS Gene Polymorphism with Essential Hypertension: A Case-Control Study

Singh

Jajodia

Kaur

et al. 2014

BioMed Research International

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Renin-angiotensin system (RAS) polymorphisms have been studied as candidate risk factors for hypertension with inconsistent results, possibly due to heterogeneity among various genetic and environmental factors. A case-control association study was conducted to investigate a possible involvement of polymorphisms of three RAS genes: AGT M235T (rs699), ACE I/D (rs4340) and G2350A (rs4343), and AGTR1 A1166C (rs5186) in essential hypertensive patients. A total of 211 cases and 211 controls were recruited for this study. Genotyping was performed using PCR-RFLP method. The genotype and allele distribution of the M235T variant differed significantly in hypertensives and normotensives (OR-CI = 2.62 (1.24–5.76), P = 0.006; OR-CI = 0.699 (0.518–0.943), P = 0.018), respectively. When the samples were segregated based on sex, the 235TT genotype and T allele were predominant in the female patients (OR-CI = 5.68 (1.60-25.10), P = 0.002; OR-CI = 0.522 (0.330–0.826), P = 0.005) as compare to the male patients (OR-CI = 1.54 (1.24–5.76), P = 0.34; OR-CI = 0.874 (0.330–0.826), P = 0.506), respectively. For ACE DD variant, we found overrepresentation of “I”-allele (homozygous II and heterozygous ID) in unaffected males which suggest its protective role in studied population (OR-CI = 0.401 (0.224–0.718); P = 0.0009). The M235T variant of the AGT is significantly associated with female hypertensives and ACE DD variant could be a risk allele for essential hypertension in south India.

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“…The (CT)n polymorphism in the 5'-flanking region of the NPRA gene also was found to be significantly associated with EH, probably through the downregulation of NPRA gene transcription (Usami et al, 2008). In a Greek population, no association between NPRA gene polymorphisms and hypertension were found (Tsezou et al, 2008).…”

Section: Discussionmentioning

confidence: 91%

“…Considerable efforts have been made to elucidate the genetic determinants of hypertension, or elevated blood pressure (BP) levels. A body of evidence suggests that A-type natriuretic peptide receptor (NPRA, NPR1) and C-type natriuretic peptide receptor (NPRC, NPR3) are associated with hypertension (Pitzalis et al, 2003;Tsezou et al, 2008;Liu et al, 2012). NPRA and NPRC are receptors of ANP and BNP; ANP and BNP counterbalance the actions of the renin-angiotensin-aldosterone and neurohormonal systems and play a central role in cardiovascular regulation.…”

Section: Introductionmentioning

confidence: 99%

Association of NPRA and NPRC gene variants and hypertension in Mongolian population

Qin

et al. 2015

Genet. Mol. Res.

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ABSTRACT. NPRA and NPRC are candidate susceptibility genes for essential hypertension (EH) and play a key role in the regulation of plasma levels and biological effects of natriuretic peptides. The aims of the present study were to find new genetic markers in the NPRA and NPRC genes and to assess relationships between variants and EH. A total of 797 unrelated Mongolian herdsmen were enrolled, including 389 EH patients and 408 normotensive controls. Genotyping was performed using the polymerase chain reaction/ligase detection reaction assay. The distribution of the T-allele frequency of rs1847018 in NPRC differed significantly between hypertensive subjects and controls. There was an association between rs1847018 and EH in the additive model in NPRC (P < 0.05). There were no significant differences in the genotype and allele frequency distributions for any of the 3 single nucleotide polymorphisms in NPRA between EH and normotensive individuals. In NPRA, the frequency of haplotype TCA in the EH group was significantly lower than in controls, while the frequency of haplotype TCG was significantly higher in the EH group than in controls; Individuals who possessed the TCA haplotype had a significantly lower ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 18494-18502 (2015) 18495NPRA and NPRC gene variants and hypertension ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 18494-18502 (2015) risk of EH, whereas the presence of haplotype TCG was significantly associated with a higher risk of EH. However, there was no significant difference between the EH group and controls in any of the 8 haplo types in NPRC. Rs1847018 is a genetic marker of EH in NPRC, and the frequency of haplotype TCA and TCG in NPRA is associated with EH in the Mongolian population.

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Association of renin-angiotensin system and natriuretic peptide receptor A gene polymorphisms with hypertension in a Hellenic population

Cited by 12 publications

References 32 publications

The association of ACE I/D gene polymorphism with severe carotid atherosclerosis in patients undergoing carotid endarterectomy

The association of ACE I/D gene polymorphism with severe carotid atherosclerosis in patients undergoing carotid endarterectomy

Gender Specific Association of RAS Gene Polymorphism with Essential Hypertension: A Case-Control Study

Association of NPRA and NPRC gene variants and hypertension in Mongolian population

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