Association of REL Polymorphism with Cow's Milk Proteins Allergy in Pediatric Algerian Population

Rahmoun, Nesrine; Mecherfi, Kamel Eddine El; Bouchetara, Assia; Hetraf, Sara Lardjem; Amira, Chahinez Dahmani; Neggaz, Leila Adda; Boudjema, Abdallah; Zemani-Fodil, Faouzia; Khéroua, O.

doi:10.1080/15513815.2017.1405468

Cited by 5 publications

(4 citation statements)

References 49 publications

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“…This allelic distribution is close to the findings of a study performed in 2018 on a sample of 58 subjects in the Western Algeria (0.10). [38] The same observation was reported in other populations such as Italians (0.12), [39] Swedish, Australian, Finnish, and English populations (0.16). [40] This frequency is lower than that reported in the African-Americans (0.43) [41] and Indians (0.39).…”

Section: Discussionsupporting

confidence: 74%

Association of IL4 rs2070874, FoxP3 rs3761548 Polymorphisms with Keratoconus in Algeria

Meteoukki

Mostefa

Negaz

et al. 2021

JOVR

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Purpose: The aim of this case–control study was to determine the impact of environmental factors on the predisposition to develop keratoconus in a sample of Western Algerian population. Subsequently, we were interested in the implication of two single nucleotide polymorphisms (SNPs) IL4 rs2070874 and FOXP3 rs3761548, previously described as contributing to the occurrence of allergy, in the development of keratoconus. Methods: The study included 70 unrelated KC cases and 70 controls originating from Western Algeria. DNA genotyping was done using predesigned probe-based allelic discrimination TaqMan® assays. Allele and genotype frequencies were compared between the cases and controls by Chi-square test and odds ratios with 95% confidence intervals. Results: A significant association between risk factors such as family history, atopy, eye rubbing, and the development of keratoconus was found in our sample. Smoking would provide a protective effect against the pathology. No statistically significant differences were found in the allele and genotype frequencies between cases and controls neither for IL4 rs2070874 nor for FOXP3 rs3761548. Conclusion: Our study provides, for the first time, a clear demonstration of the absence of association of the allergy-associated IL4 and FOXP3 polymorphisms with KC in a sample from Western Algerian population.

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Section: Discussionsupporting

confidence: 74%

Association of IL4 rs2070874, FoxP3 rs3761548 Polymorphisms with Keratoconus in Algeria

Meteoukki

Mostefa

Negaz

et al. 2021

JOVR

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“…Recently, several studies have found that polymorphisms in the IL-13 and IL-4 genes are often associated with an increased risk of allergic diseases, including atopic dermatitis, allergic rhinitis, and bronchial asthma [ 11 , 12 ]. At the same time, the influence of polymorphisms of these genes on the development of CMA in children remains unclear [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Polymorphic Variants of Interleukin-13 R130Q and Interleukin-4 T589C in Children with and without Cow’s Milk Allergy

Matsyura

Беш

Kens

et al. 2022

Life

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Cow’s milk allergy (CMA) is one of the most frequent types of food allergy. The aim of the study was to investigate whether IL-13 R130Q and IL-4 T589C polymorphisms are associated with the risk of CMA in young Ukrainian children. A total of 120 children (age range: 1–3 years) participated in the study and were divided into two groups: CMA (n = 60) and healthy controls (CNT, n = 60). The CMA group had two subgroups: specific oral tolerance induction (SOTI, n = 30) and milk elimination diet (MED, n = 30). The CNT group had two subgroups: positive family history of allergy (+FHA, n = 24) and negative family history of allergy (−FHA, n = 36). In the CMA group, molecular genetic testing of CC, CT, and TT genotypes of single nucleotide IL-4 T589C gene polymorphisms showed significantly higher rates of the CC genotype compared to healthy controls (92.2% vs. 58.8%; p < 0.01). In the CMA group, molecular genetic testing of GG, GA, and AA genotypes of single nucleotide IL-13 R130Q gene polymorphisms showed significantly higher rates of GA and AA polymorphic locus genotypes compared to healthy controls (43.5% vs. 22.4%, p < 0.05 and 8.7% vs. 0%, p < 0.05, respectively). In future studies, the genotypic and allelic distribution of these polymorphic variants will be determined in children with CMA and healthy children.

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“…The sharp increase in allergic diseases in a rather short time period is pointing towards the importance of environmental influences that are typically mediated by epigenetic mechanisms [ 5 , 6 , 7 , 8 , 9 ]. Not surprisingly, also in the case of CMA, while the genetic background is being further elucidated [ 10 , 11 , 12 , 13 , 14 , 15 ], more and more attention is now being paid to the role of epigenetics.…”

Section: Introductionmentioning

confidence: 99%

Decreased Histone Acetylation Levels at Th1 and Regulatory Loci after Induction of Food Allergy

et al. 2020

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Immunoglobulin E (IgE)-mediated allergy against cow’s milk protein fractions such as whey is one of the most common food-related allergic disorders of early childhood. Histone acetylation is an important epigenetic mechanism, shown to be involved in the pathogenesis of allergies. However, its role in food allergy remains unknown. IgE-mediated cow’s milk allergy was successfully induced in a mouse model, as demonstrated by acute allergic symptoms, whey-specific IgE in serum, and the activation of mast cells upon a challenge with whey protein. The elicited allergic response coincided with reduced percentages of regulatory T (Treg) and T helper 17 (Th17) cells, matching decreased levels of H3 and/or H4 histone acetylation at pivotal Treg and Th17 loci, an epigenetic status favoring lower gene expression. In addition, histone acetylation levels at the crucial T helper 1 (Th1) loci were decreased, most probably preceding the expected reduction in Th1 cells after inducing an allergic response. No changes were observed for T helper 2 cells. However, increased histone acetylation levels, promoting gene expression, were observed at the signal transducer and activator of transcription 6 (Stat6) gene, a proallergic B cell locus, which was in line with the presence of whey-specific IgE. In conclusion, the observed histone acetylation changes are pathobiologically in line with the successful induction of cow’s milk allergy, to which they might have also contributed mechanistically.

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Association of REL Polymorphism with Cow's Milk Proteins Allergy in Pediatric Algerian Population

Abstract: The results of this study suggest a possible association of CMPA with cRel G+7883T polymorphism.

Cited by 5 publications

References 49 publications

Association of IL4 rs2070874, FoxP3 rs3761548 Polymorphisms with Keratoconus in Algeria

Association of IL4 rs2070874, FoxP3 rs3761548 Polymorphisms with Keratoconus in Algeria

Polymorphic Variants of Interleukin-13 R130Q and Interleukin-4 T589C in Children with and without Cow’s Milk Allergy

Decreased Histone Acetylation Levels at Th1 and Regulatory Loci after Induction of Food Allergy

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