Association of Red Blood Cell Distribution Width Levels with Severity of Coronary Artery Disease in Patients with Non-ST Elevation Myocardial Infarction

Abstract

Objectives: The aim of this study was to evaluate the association of the levels of red blood cell distribution width (RDW) with the severity of atherosclerosis and to determine whether or not the RDW level on admission is an independent predictor of all-cause mortality in patients with non-ST elevation myocardial infarction (NSTEMI). Materials and Methods: A total of 335 consecutive patients with NSTEMI were enrolled in this study. The patients were divided into high (n = 105) and low (n = 230) SYNTAX groups. The high SYNTAX group was defined as patients with a value in the third tertile (SYNTAX score, SXscore ≥12), while the low SYNTAX group was defined as those with a value in the lower 2 tertiles (SXscore <12). The high RDW group (n = 152) was defined as patients with RDW >14.25% and the low RDW group (n = 183) as those with RDW ≤14.25%. All-cause mortality was followed up to 38 months. Results: The mean follow-up period was 18 ± 11 months. The RDW levels of patients were significantly higher in the high SYNTAX group than in the low SYNTAX group (15.2 ± 1.8 vs. 14.2 ± 1.2, p < 0.001). Pearson's coefficients were used to determine the degree of association between RDW levels and SXscore and also between RDW levels and high-sensitivity C-reactive protein. There was a significant correlation between RDW levels and SXscore (r = 0.460, p < 0.001). Also, there was a significant correlation between RDW levels and high-sensitivity C-reactive protein (r = 0.180, p = 0.001). All-cause mortality rate was not significantly different between the high and low RDW groups (log-rank, p = 0.621). Conclusion: RDW levels were independently associated with high SXscore but were not associated with long-term mortality in NSTEMI patients.

Prognostic value of red blood cell distribution width in patients with left ventricular systolic dysfunction: Insights from the COMMIT-HF registry

“…Elevated RDW had been shown to predict poor outcomes in the normal population [15,16], in patients with CAD [2][3][4][5][6], and in patients with HF [8][9][10][11][12]. The present analysis is the first to demonstrate the predictive value of RDW both in patients with ischemic and nonischemic LVSD.…”

“…In recent years, anisocytosis has emerged as a prognostic biomarker in cardiovascular disease. Numerous studies have noted the relationship between RDW values and adverse clinical outcomes in the setting of coronary artery disease (CAD), including patients undergoing percutaneous coronary interventions in the course of stable coronary artery disease and patients with acute coronary syndromes (ACS) [2][3][4][5][6].…”

Red Cell Distribution Width in Myocardial Infarction

“…We read the article ‘Association of red blood cell distribution width levels with severity of coronary artery disease in patients with non-ST elevation myocardial infarction’ by Sahin et al [1] with interest. They aimed to evaluate the association of the levels of red blood cell distribution width (RDW) with the severity of atherosclerosis and to determine whether or not the RDW level on admission was an independent predictor of all-cause mortality in patients with non-ST elevation myocardial infarction (NSTEMI).…”

The Side Effect of Haloperidol in Schizophrenic Patients: Analysis of Red Blood Cell Distribution Width (RDW) and Mean Platelet Volume (MPV) Values

“…Sahin et al (2014), illustrate the strong relationship between RDW values and the severity of coronary artery disease in patients with non-ST elevation myocardial infarction. Becker et al (2009) also found that MPV is a predictor of cardiovascular risk (Chu et al, 2010;Danese, Lippi, & Montagnana, 2015;Keser et al, 2016;Sahin et al, 2015).…”