Red Cell Distribution Width in Myocardial Infarction

Balta, Şevket; Demırkol, Sait; Aparcı, Mustafa; Arslan, Zekeriya; Öztürk, Cengiz

doi:10.1159/000437355

Cited by 5 publications

(6 citation statements)

References 8 publications

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“…In this present study, there was a lack of significant association between MCV and mortality in the adjusted model. This finding is consistent with findings of Peng et al 31 , in incident peritoneal dialysis patients, MCV was not statistically significantly associated with mortality in the fully adjusted model, and is consistent with findings of Chen et al 32 among haemodialysis patients, where the two year survival rate was significantly lower in the high red cell distribution width group, Balta et al 33 , found lower death rate among patients with higher MCV, though his cohort were patients with myocardial infarction. This finding is in contrast to findings by Hsieh et al among stage 3–5 CKD patients 34 , Sun et al among peritoneal dialysis patients in Korea, Brain et al 35 and Vashistha et al 36 among haemodialysis patients.…”

Section: Discussionsupporting

confidence: 90%

A cohort study of the relationship between anaemia, mean corpuscular volume and mortality among a CKD population in South Africa

Nalado¹,

Waziri²,

Olorunfemi³

et al. 2021

Afr H. Sci.

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Background: The burden of chronic kidney disease is increasing globally and prompt identification, coupled with improved management of CKD patients have increased the population of pre-dialysis patients. We, therefore, aimed to evaluate the predictors of survival among pre-dialysis CKD patients in South Africa. Methods: We conducted a cohort study of 256 consecutive consenting Black non-dialysis requiring CKD patients attending the renal outpatient clinic of a tertiary Hospital in South Africa from 1st June 2016 to 1st December 2016. Socio-demographic and clinical information of the participants were obtained. Descriptive statistics, Kaplan-Meier curves and Cox proportional hazard regression analyses were conducted to evaluate factors affecting the survival of the participants. Results: The mean age of the participants was 52.8±14.3 years and 48.0% were females, 52% were males. The death rate increased with worsening haemoglobin level from 0.96 among patients with mild anaemia to 4.29 per 100-person years among patients with severe anaemia. Anaemic patients with GFR < 30mls/min had significantly increased risk of death (HR 11.51, 95% CI 1.62–78.32, P < 0.001). Conclusion: Mortality in pre-dialysis CKD patients was associated with anaemia and hyperphosphatemia. Clinical interventions targeted at preventing these conditions may improve outcomes among this group of CKD patients. Keywords: Chronic kidney disease; mortality anaemia; outcomes, survival.

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Section: Discussionsupporting

confidence: 90%

A cohort study of the relationship between anaemia, mean corpuscular volume and mortality among a CKD population in South Africa

Nalado¹,

Waziri²,

Olorunfemi³

et al. 2021

Afr H. Sci.

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“…Exact physiological mechanisms between RDW and cardiovascular outcomes are not clearly understood. Several previous studies suggest that the level of RDW may reflect the extent oxidative stress, chronic subclinical inflammation, and lipid abnormalities [ 1 , 27 , 28 ]. Similar to previous studies [ 29 ], a significant positive correlation between hsCRP and RDW was established in our study, which indicating that RDW was significantly related to the inflammatory response intensity in STEMI patients undergoing primary PCI.…”

Section: Discussionmentioning

confidence: 99%

“…Similar to previous studies [ 29 ], a significant positive correlation between hsCRP and RDW was established in our study, which indicating that RDW was significantly related to the inflammatory response intensity in STEMI patients undergoing primary PCI. Additionally, oxidative stress and inflammation result in disorders of iron metabolism and decrease the production of and response to erythropoietin, which thus might contribute to an increased RDW level [ 1 , 27 ]. However, contrary to previous studies [ 28 ], our data failed to find the correlation between RDW and lipids.…”

Section: Discussionmentioning

confidence: 99%

Combined value of red blood cell distribution width and global registry of acute coronary events risk score on predicting long-term major adverse cardiac events in STEMI patients undergoing primary PCI

et al. 2018

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The combined value of RDW and GRACE risk score for cardiovascular prognosis in ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) has not been fully investigated. This study was designed to explore the combined value of RDW and GRACE risk score on predicting long-term major adverse cardiac event (Mace) in STEMI patients undergoing primary PCI. This study included 390 STEMI patients. The primary endpoint at the (33.5 ± 7.1) months follow-up was composed of cardiac death and nonfatal myocardial infarction. The relationship between clinical parameters and clinical outcomes was evaluated using Cox regression model and receiver operating characteristic (ROC) analysis. Mace occurred in 126 (32.3%) patients including 54 (13.8%) cardiac deaths and 72 (18.5%) nonfatal myocardial infarctions. Patients in Mace group had significantly higher RDW and GRACE score than the patients in non-Mace group. According to the Cox model, RDW and GRACE score were the most important independent predictors of Mace and cardiac death. The best cut-off value for RDW to predict the occurrence of primary events was 13.25% (AUC = 0.694, 95% CI:0.639–0.750, P < 0.001) and that for GRACE score was 119.5 (AUC = 0.721, 95% CI:0.666–0.777, P < 0.001). The combination of RDW and GRACE score were more valuable (AUC = 0.775, 95% CI: 0.727–0.824, P < 0.001). Kaplan–Meier analysis provided significant prognostic information with the highest risk for cardiac death (Log-Rank χ2 = 24.684, P < 0.001) in group with both high RDW (> 13.25%) and high GRACE score (> 119.5). The combination of RDW level and GRACE score may be valuable and simple independent predictors of Mace and cardiac death in STEMI patients undergoing primary PCI. They may be useful tools for risk stratification and may indicate long-term clinical outcomes.

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“…Also, it would be better if the authors might define how much time they specified on measuring RDW levels, because delaying blood sampling can lead to abnormal results in RDW assessments. 8) …”

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confidence: 99%