2019
DOI: 10.1001/jamapsychiatry.2019.1944
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Association of Psychiatric Comorbidity With the Risk of Premature Death Among Children and Adults With Attention-Deficit/Hyperactivity Disorder

Abstract: IMPORTANCE A previous register-based study reported elevated all-cause mortality in attention-deficit/hyperactivity disorder (ADHD), but cause-specific risks and the potential associations of psychiatric comorbidities remain unknown.OBJECTIVES To investigate the all-cause and cause-specific mortality risks in ADHD and to explore the potential role of psychiatric comorbidities. DESIGN, SETTING, AND PARTICIPANTSThis prospective cohort study used Swedish national registers to identify 2 675 615 individuals born i… Show more

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Cited by 102 publications
(114 citation statements)
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“…There are but a few naturalistic studies tracking the long‐term clinical and functional outcomes in adult ADHD (Hodgkins et al ., 2012), calling for more studies to understand long‐term trajectory regarding symptoms and functioning levels in ADHD as it presents in real‐world settings (Cortese et al ., 2018; Shaw et al ., 2012). Intensified focus on the long‐term consequences of ADHD and its treatment is important because of the heightened awareness among laypeople, high heritability (74%, because of the tendency of ADHD to run in families and through generations; Faraone & Larsson, 2019) and the profound effects ADHD has on life quality (see for example Chang et al ., 2014; Dalsgaard, Østergaard, Leckman, Mortensen & Pedersen, 2015; Sun, Kuja‐Halkola, Faraone et al ., 2019).…”
Section: Introductionmentioning
confidence: 99%
“…There are but a few naturalistic studies tracking the long‐term clinical and functional outcomes in adult ADHD (Hodgkins et al ., 2012), calling for more studies to understand long‐term trajectory regarding symptoms and functioning levels in ADHD as it presents in real‐world settings (Cortese et al ., 2018; Shaw et al ., 2012). Intensified focus on the long‐term consequences of ADHD and its treatment is important because of the heightened awareness among laypeople, high heritability (74%, because of the tendency of ADHD to run in families and through generations; Faraone & Larsson, 2019) and the profound effects ADHD has on life quality (see for example Chang et al ., 2014; Dalsgaard, Østergaard, Leckman, Mortensen & Pedersen, 2015; Sun, Kuja‐Halkola, Faraone et al ., 2019).…”
Section: Introductionmentioning
confidence: 99%
“…[ 2 , 3 ]. Moreover, ADHD shows significant correlations with a wide range of comorbid psychiatric disorders, including affective disorders, defiant, antisocial personality disorder, self-harm, substance misuse, placing a considerable burden on society and family [ 1 , 4 , 5 ].…”
mentioning
confidence: 99%
“…Also, recent epidemiological studies show that ADHD is associated with an increased mortality rate. Premature deaths were mostly caused by (traffic) accidents or unintentional injuries and mostly occurred in the subgroup of patients with ADHD and comorbid SUDs [12,13]. In a recent study on patients in trauma surgery after accidents, ADHD prevalence was increased compared to the general population.…”
Section: Discussionmentioning
confidence: 99%
“…Patients with ADHD act impulsively and tend to be inattentive or easily distracted which likely explains why they are at higher risk for fatal and nonfatal accidents and unintentional injuries [11][12][13]. Therefore, it is not surprising that patients with ADHD have a higher risk for potentially traumatic events (PTEs) than their peers without ADHD.…”
Section: Introductionmentioning
confidence: 99%