Association of Psoriasis With Coronary Artery, Cerebrovascular, and Peripheral Vascular Diseases and Mortality

Prodanovich, Srjdan; Kirsner, Robert S.; Kravetz, Jeffrey D.; Ma, Fangchao; Martínez, Lisa; Federman, Daniel G.

doi:10.1001/archdermatol.2009.94

Cited by 363 publications

(328 citation statements)

References 24 publications

Supporting

Mentioning

306

Contrasting

Unclassified

Order By: Relevance

“…Prodanovich et al 79 2009 After controlling for risk factors, patients with psoriasis had a higher prevalence of ischemic heart disease, cerebrovascular, and peripheral vascular disease . Psoriasis was also found to be an independent risk factor for mortality 9 of 11…”

Section: Of 11mentioning

confidence: 99%

“…In a study of over 3,000 psoriasis patients from the Veteran's Administration Hospital database, investigators found higher prevalence rates of ischemic heart disease, stroke and PVD, after controlling for age, sex, DM, HTN, dyslipidemia, and smoking. 79 Recent high quality work revealed an increased risk of stroke for mild and severe psoriasis. 80 In particular, severe psoriasis confers an increased risk of stroke not explained by major risk factors alone.…”

Section: Peripheral Vascular Disease and Cerebrovascular Diseasementioning

confidence: 99%

“…In a multivariate analysis, psoriasis was an independent risk factor for all-cause mortality, even after controlling for CVD risk factors and vascular disease. 79 Moreover, there are increased standardized mortality ratios for men and women with PsA. 84 …”

Section: Impact Of Psoriasis On Cvd and Total Mortalitymentioning

confidence: 99%

See 2 more Smart Citations

Psoriasis and Vascular Disease—Risk Factors and Outcomes: A Systematic Review of the Literature

et al. 2011

Self Cite

View full text Add to dashboard Cite

Section: Of 11mentioning

confidence: 99%

Section: Peripheral Vascular Disease and Cerebrovascular Diseasementioning

confidence: 99%

See 1 more Smart Citation

Psoriasis and Vascular Disease—Risk Factors and Outcomes: A Systematic Review of the Literature

et al. 2011

Self Cite

View full text Add to dashboard Cite

“…Most recently, a relationship between psoriasis and increased risk of myocardial infarction, cerebrovascular disease, and peripheral vascular (cardiovascular) disease has been reported (3)(4)(5). The observed excess risk appears to be greatest in younger patients and those with more severe psoriasis.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular and other comorbidities in patients with psoriatic arthritis: A comparison with patients with psoriasis

Husted¹,

Thavaneswaran²,

Chandran³

et al. 2011

Arthritis Care & Research

226

191

View full text Add to dashboard Cite

Objective. To determine whether the presence of psoriatic arthritis (PsA) is associated with greater comorbidity, in particular cardiovascular morbidity, compared to psoriasis without arthritis. Methods. Six hundred eleven patients with PsA were recruited from the University of Toronto Psoriatic Arthritis Clinic and 449 psoriasis without arthritis patients were recruited from the University of Toronto Psoriasis Cohort. The clinical database was used to identify the prevalence of cardiovascular and other comorbidities in both PsA and psoriasis without arthritis patients. Univariate and multivariate logistic regression analyses were conducted to estimate odds ratios (ORs), comparing the odds of ever having a given comorbid disease in PsA patients with those in psoriasis without arthritis patients. Covariates included age, sex, education, smoking status, severity and duration of psoriasis, medication status, and other comorbidities. Results. The prevalence of hypertension, obesity, hyperlipidemia, type 2 diabetes mellitus, and at least 1 cardiovascular event in PsA patients was 37.1%, 30.0%, 20.7%, 12.0%, and 8.2%, respectively. This was significantly higher than in psoriasis without arthritis patients, with unadjusted ORs ranging from 1.54 to 2.59. In the multivariate analyses, hypertension remained significantly elevated (adjusted OR 2.17). PsA was also significantly associated with infections not treated with antibiotics (presumably viral), neurologic conditions, gastrointestinal disorders, and liver disease (adjusted ORs 2.83, 4.76, 21.53, and 7.74, respectively). Infections treated with antibiotics and depression/anxiety were relatively common in PsA, with a prevalence of 30.5% and 20.7%, respectively. However, this was not significantly different from psoriasis without arthritis after multivariate adjustments. Conclusion. The results suggest that inflammatory joint disease may play a role in both cardiovascular and noncardiovascular morbidity in PsA.

show abstract

“…An increase in mortality is observed in patients with severe disease and is most pronounced in young patients. [3][4][5][6][7][8] Specific biomarkers aid in detecting disease, determining the activity and the severity and evaluating the response to therapy and monitoring disease progression. Cardiovascular biomarkers, many of which are also mediators of inflammation, have previously been studied in psoriasis patients.…”

Section: Introductionmentioning

confidence: 99%

Systemic treatment and narrowband ultraviolet B differentially affect cardiovascular risk markers in psoriasis

Sigurdardottir

Ekman

Ståhle

et al. 2014

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

show abstract

Association of Psoriasis With Coronary Artery, Cerebrovascular, and Peripheral Vascular Diseases and Mortality

Abstract: To examine the cardiovascular risk factors in patients with psoriasis and the association between psoriasis and coronary artery, cerebrovascular, and peripheral vascular diseases.

Cited by 363 publications

References 24 publications

Psoriasis and Vascular Disease—Risk Factors and Outcomes: A Systematic Review of the Literature

Psoriasis and Vascular Disease—Risk Factors and Outcomes: A Systematic Review of the Literature

Cardiovascular and other comorbidities in patients with psoriatic arthritis: A comparison with patients with psoriasis

Systemic treatment and narrowband ultraviolet B differentially affect cardiovascular risk markers in psoriasis

Contact Info

Product

Resources

About