2016
DOI: 10.2147/rru.s117963
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Association of prostate volume with incidence and aggressiveness of prostate cancer

Abstract: ObjectiveThe aim of this study was to investigate the possible correlation between prostate volume and aggressiveness and incidence of prostate cancer (PCa).Patients and methodsA chart review of a cohort of 448 consecutive prostate biopsy-naive men was performed. These men underwent at least a 12-core biopsy at our institution due to increased prostate-specific antigen serum levels (>4 ng/mL) and/or suspicious findings on digital rectal examination during the period between 2008 and 2013. Transrectal ultrasoun… Show more

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Cited by 32 publications
(31 citation statements)
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“…In this study, we performe a comprehensive investigation of 18 BPH cases via next-generation sequencing technology. We selected samples from patients with very large prostates (top 1 percentile and greater than 100cc), based on the rationale that these extreme outliers were more likely to harbor biologically informative events 25 .…”
mentioning
confidence: 99%
“…In this study, we performe a comprehensive investigation of 18 BPH cases via next-generation sequencing technology. We selected samples from patients with very large prostates (top 1 percentile and greater than 100cc), based on the rationale that these extreme outliers were more likely to harbor biologically informative events 25 .…”
mentioning
confidence: 99%
“…An article published in your journal, by Boehm et al concluded that BPH was associated with an increased risk of PCa, however, this increased risk was limited to BPH diagnosed within the previous year and was more evident with respect to low-grade cancers (Gleason score ≤6) [1]. However, our institution has recently presented data showing an inverse correlation between prostate volume, caused by BPH, and the incidence and aggressiveness of PCa [2,3]. Table 1 below displays the breakdown between incidence and aggressiveness of PCa with respect to prostate volume.…”
Section: Dear Editormentioning
confidence: 80%
“…Previous phytochemical studies have revealed that C. spinosa contains nine types of flavonoids (quercetin-3-O-glucuronide, quercetin-3-O-rutinoside, quercetin-3-O-glucoside, kaempferol-3-O-glucuronide, kaempferol-3-O-rutinoside, kaempferol-3-O-glucoside, isorhamnetin-3-O-glucuronide, isorhamnetin-3-O-rutinoside, and isorhamnetin-3-O-glucoside) and a phenolic compound (p-hydroxyacetophenone), which the flavonoid isorhamnetin-3-O-glucuronide has anti-inflammatory activity in vitro and the flavonoids kaempferol and quercetin are inversely associated with lung cancer 29,30. Finally, experimental trials have shown antioxidant, anti-inflammatory, and antifungal activity of the methanolic extract.…”
Section: Discussionmentioning
confidence: 99%