Association of benign prostatic hyperplasia (BPH) volume and prostate cancer: consecutive data from an academic institution in respect to the current scientific view

Khalil, Shadi; Riese, Werner de

doi:10.1007/s00345-017-2031-7

Cited by 2 publications

(2 citation statements)

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“…Moreover, microbial structure imbalance promotes the activation of immune response and chronic inflammation and growth of epithelial and stromal tissues in prostate, which is main features of BPH (4). Increasing studies reveal that men with BPH are more conducive to PCa and PCa-related death (5)(6)(7). However, whether this association indicates a causal link, shared risk factors or pathophysiological mechanisms, or detection bias has not been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Urine flora imbalance and new biomarkers in prostate cancer and benign prostatic hyperplasia

Yin

Zhang

et al. 2021

Arch Med Sci

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IntroductionMicrobial structure is closely associated with the initiation and development of various diseases. However, the roles of urine flora in prostate diseases, including prostate cancer (PCa) and benign prostatic hyperplasia (BPH) are still unclear.Material and methodsIn this study, clinical samples were collected from PCa (n=21) and BPH (n=19) patients and healthy people (n=12). The analysis of urine flora DNA sequencing and hematological testing results between every two groups was performed by using bioinformatic methods, including alpha and beta diversity analysis, and functional PICRUSt analysis.ResultsThe results showed that the microbial structure in PCa and BPH differentiated from healthy control. Escherichia coli was increased in PCa and BPH patients, while probiotics, such as, Lactobacillus helveticus and Lactobacillus iners was decreased. Moreover, beta diversity in PCa group was different with control group, while alpha diversity showed no significant changes. Spearman analysis showed that Escherichia coli was negatively correlated with Lactobacillus helveticus and Lactobacillus iners. Microbial imbalance was associated with energy metabolism in PCa and with cell motility, energy metabolism, and intracellular trafficking, secretion, and vesicular transport in BPH. Moreover, microbial imbalance was associated with nervous disorders and infectious diseases in PCa, and with metabolic system, infectious diseases, and signal transduction BPH.ConclusionsTaken together, microbial imbalance may be associated with PCa and BPH. The increase of Escherichia coli was accompanied by the decrease of probiotics, such as Lactobacillus helveticus and Lactobacillus iners. This may be the biomarkers for risk prediction and early treatment for prostate disease.

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Section: Introductionmentioning

confidence: 99%

Urine flora imbalance and new biomarkers in prostate cancer and benign prostatic hyperplasia

Yin

Zhang

et al. 2021

Arch Med Sci

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“…Therefore, finding a more targeted and more effective prostate cancer drug target, and in-depth understanding of the molecular mechanism of tumorigenesis are essential for early intervention and treatment of prostate cancer. 2 microRNAs (MiRNAs) are small, highly conserved non-coding RNAs that control gene expression by binding to the seed sequence of the target 3’-untranslated region (3’UTR), resulting in translational inhibition or mRNA degradation. miRNAs are regulatory factors of human carcinogenesis, embryonic development, and cell aging.…”

Section: Introductionmentioning

confidence: 99%

ESTAT3 Inhibitor AG-490 Inhibits the Growth of Prostate Cancer by miR-503-5p Both In Vivo and In Vitro

Tan

Jiang

Gang-Qin

et al. 2020

Technol Cancer Res Treat

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Objective: To explore the effect and the related mechanism of STAT3 inhibitor AG-490 on inhibiting the proliferation of prostate cancer cells. Methods: PC3 cells and DU145 cells were cultured stably and treated with AG-490 to detect the changes in the activity of PC3 cells and DU145 cells. Thirty 6-8 weeks male BALB/c nude mouse were randomly divided into a control group, a DMSO group, and an AG-490 group to detect differences in various indexes . Results: The overexpression of miR-503-5p depends on the activation of STAT3. After treatment with AG-490, The proliferation and invasion of PC3 cells and DU145 cells and the expression of miR-503-5p were all reduced. Luciferase reporter assay demonstrated that the target proteins of miR-503-5p include PDCD4, TIMP-3, and PTEN. After treatment with AG-490, the expression of PDCD4, TIMP-3, and PTEN in cells was significantly up-regulated. IL-6-induced overexpression of miR-503-5p and restored the expression of STAT3, demonstrating the correlation between STAT3 and miR-503-5p. AG-490 can inhibit tumor growth and induce tumor cell apoptosis in the PC3 BALB/c nude mouse xenograft model. Western blotting and immunohistochemical staining showed that the expression levels of STAT3, Ki67, Bcl-2 and MMP-2 in the AG-490 group were significantly reduced, and the expression of PDCD4, TIMP-3 and PTEN increased. Conclusion: AG-490 can inhibit the growth of prostate cancer cells in a miR-503-5p-dependent manner by targeting STAT3. AG-490 is expected to become a new candidate drug for the treatment of prostate cancer.

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Association of benign prostatic hyperplasia (BPH) volume and prostate cancer: consecutive data from an academic institution in respect to the current scientific view

Cited by 2 publications

References 8 publications

Urine flora imbalance and new biomarkers in prostate cancer and benign prostatic hyperplasia

Urine flora imbalance and new biomarkers in prostate cancer and benign prostatic hyperplasia

ESTAT3 Inhibitor AG-490 Inhibits the Growth of Prostate Cancer by miR-503-5p Both In Vivo and In Vitro

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