Association of Prostate Size and Tumor Grade in Korean Men with Clinically Localized Prostate Cancer

Hong, Sung Kyu; Yu, Ji Hyung; Han, Byoung Hee; Chang, In Ho; Jeong, Seong Jin; Byun, Seok‐Soo; Lee, Hak Jong; Choe, Gheeyoung; Lee, Sang Eun

doi:10.1016/j.urology.2007.03.006

Cited by 18 publications

(22 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At present, the screening of prostate cancer in Korea is not as widespread as in Western countries (29). Furthermore, among Korean men, prostate cancer accounts for 2.4% and 1.5% of the total cancer cases and deaths, respectively (30,31).…”

Section: Discussionmentioning

confidence: 99%

Second to fourth digit ratio: its relationship with core cancer volume and Gleason score in prostate biopsy

Kim

Jung

et al. 2012

Int. braz j urol.

View full text Add to dashboard Cite

ARTICLE INFO _________________________________________________________ ___________________Objective: To investigate the relationships between 2nd to 4th digit ratio (digit ratio) and prostate cancer detection rate and biopsy findings, including Gleason score. Materials and Methods:In 770 consecutive men aged 40 years or older that presented with lower urinary tract symptoms (LUTS), right hand 2nd and 4th digit lengths were measured prior to PSA determinations, DRE and transrectal ultrasonography (TRUS). Among these, 166 men with a prostate specific antigen (PSA) level ≥ 3 ng/mL or abnormal digit rectal examination (DRE) prospectively underwent prostate biopsies. The relationship between digit ratio and prostate cancer detection rate and biopsy findings was investigated. Results: The study subjects were allocated to two groups by digit ratio (group A: digit ratio < 0.95; n = 420; group B: digit ratio ≥ 0.95; n = 350). Despite similar biopsy rates (22.4% vs. 20.6%, p = 0.544), group A had higher cancer detection rate (46.8% (44/94) vs. 23.6% (17/72), p = 0.002; OR = 2.847, 95% CI = 1.445-5.610). When we analyzed 408 positive biopsy cores (group A: digit ratio < 0.95, n = 282; group B: digit ratio ≥ 0.95, n = 126), group A had higher percentage of core cancer volume (46.7% vs. 37.1%, p = 0.005) and more biopsy cores with high Gleason score (sum of Gleason score ≥ 9: 18/282 (6.4%) vs. 1/126 (0.8%), p = 0.010; primary Gleason score = 5: 12/282 (4.3%) vs. 0/126 (0.0%), p = 0.021). Conclusions: A lower digit ratio is related to an increased detection rate of prostate cancer, a high percentage of core cancer volume and a high Gleason score.

show abstract

Section: Discussionmentioning

confidence: 99%

Second to fourth digit ratio: its relationship with core cancer volume and Gleason score in prostate biopsy

Kim

Jung

et al. 2012

Int. braz j urol.

View full text Add to dashboard Cite

show abstract

“…In addition, several recent studies [23,24] have shown that prostate cancer arising in South Korean men may be more intrinsically aggressive than in American men. Song et al [23] reveal that more than 60% of patients in studies of American men had a Gleason score of 6 or less, and 58.8% of Korean men had a Gleason score of 7 or more.…”

Section: Discussionmentioning

confidence: 99%

Intermediate versus low or high prostate-specific antigen density level: Comparison of cancer detection rate between 12- and 18-core prostate biopsy

Park

Lee

Kim

et al. 2010

Scandinavian Journal of Urology and Nephrology

View full text Add to dashboard Cite

show abstract

“…20 Our previous study also showed that prostate size was a useful predictor of BCR in men with clinically localized prostate cancer. 21 Although the reason for this is not fully understood, several hypotheses have been suggested. A small prostate in patients treated with RP might be related to lower levels of pretreatment serum testosterone, which has been shown to be predictive of more aggressive prostate cancer.…”

Section: Commentmentioning

confidence: 99%

The Prognostic Value of Pathologic Prostate-specific Antigen Mass Ratio in Patients With Localized Prostate Cancer With Negative Surgical Resection Margins

Lee

Jeong

et al. 2013

Urology

Self Cite

View full text Add to dashboard Cite

Association of Prostate Size and Tumor Grade in Korean Men with Clinically Localized Prostate Cancer

Cited by 18 publications

References 20 publications

Second to fourth digit ratio: its relationship with core cancer volume and Gleason score in prostate biopsy

Second to fourth digit ratio: its relationship with core cancer volume and Gleason score in prostate biopsy

Intermediate versus low or high prostate-specific antigen density level: Comparison of cancer detection rate between 12- and 18-core prostate biopsy

The Prognostic Value of Pathologic Prostate-specific Antigen Mass Ratio in Patients With Localized Prostate Cancer With Negative Surgical Resection Margins

Contact Info

Product

Resources

About