Association of Promoter Region Polymorphisms of Interleukin-10 Gene With Susceptibility to Colorectal Cancer: A Systematic Review and Meta-Analysis

Abstract

Background -Several epidemiological studies have investigated the association of promoter region polymorphisms of Interleukin-10 (IL-10) gene with colorectal cancer (CRC), while the conclusion is still conflicting and inconclusive. Objective -We conducted this meta-analysis to evaluate the association of promoter region polymorphisms of IL-10 with CRC. Methods -Eligible articles were identified by a search of several bibliographic databases for the period up to March 15, 2018. The strength of the association was measured by odd ratios with 95% confidence intervals. Results -A total of 28 case-control studies with 5,647 CRC cases and 6,908 controls were selected, including 14 studies for IL-10 -1082A>G (rs1800896) polymorphism (2,702 cases and 3,649 controls), eleven studies for -592C>A (rs1800872) polymorphism (3,259 cases and 4,992 controls), and three studies for -819T>C (rs1800871) polymorphism (477 cases and 544 controls). By pooling all eligible studies, we found that the IL-10 -1082A>G and -592C>A polymorphisms were not associated with increased CRC risk in overall population. However, there was significant associations between the IL-10 -819T>C polymorphism and CRC susceptibility under the allele model (A vs G: OR=1.278, 95% CI 1.043-1.566, P=0.018) and the recessive model (AA vs AG+GG: OR=1.709, 95% CI 1.026-2.845, P=0.039). Conclusion -In this meta-analysis we found that IL-10 -819T>C polymorphism was associated with significantly increased risk of CRC; while the IL-10 -1082A>G and -592C>A polymorphisms were not associated with CRC risk. The IL-10 -819T>C polymorphism may be important as suspected predictive factor of CRC occurrence. HEADINGS -Interleukin-10. Colorectal neoplasms. Genetic polymorphism. Meta-analysis.

Association of IL-12B rs3212227 and IL-6 rs1800795 Polymorphisms with Susceptibility to Cervical Cancer: A Systematic Review and Meta-Analysis

“…Therefore, the assessment of heterogeneity is necessary, as high heterogeneity could be caused by the fact that there are actually two or more subgroups of studies present in the data, which have a different true effect. According to our previous metaanalyses, we suggested that heterogeneity might be due to differences in study design, sample size, genotyping methods, disease heterogeneity, and to the different roles played by gene-gene and gene-environment interactions (Aflatoonian et al, 2019a;Mirjalili et al, 2018;Moghimi et al, 2019Moghimi et al, , 2018. Moreover, after subgroup an analysis, heterogeneity was obviously decreased in Asians; however, the corresponding pooled ORs were not materially altered after deleting these studies, indicating that our results were statistically robust.…”

Gene polymorphisms of interleukin 10 (− 819 C/T and − 1082 G/A) in women with ovarian cancer

“…Also, several findings were reporting no (significant difference) association of IL10 − 1082G/A SNP with various types of cancers as a non-Hodgkin lymphoma [76], cervical cancer [77], gastric cancer [78], colorectal cancer [79], prostate cancer [80], breast cancer [23], and diffuse large B cell lymphoma DLBCL [67].…”

Association of IL-10-1082G > A, -819C > T and -592C > A Polymorphisms with susceptibility to asthma in children: a Systematic Review and Meta-Analysis

“…The IL-10 promoter is highly polymorphic [17][18][19][20], and three single nucleotide polymorphisms (SNPs) at positions -1082G>A, -819C>T and -592C>A polymorphisms within the promoter region have been shown to correlate with IL-10 production (22,24,25). To date, several genetic epidemiology studies have assessed the association between IL-10 -1082G>A, -819C>T and -592C>A polymorphisms and pediatric asthma in different populations (26,27).…”