Association of Promoter Region Polymorphisms of IL-6 and IL-18 Genes with Risk of Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis

Salimi, Erfaneh; Karimi-Zarchi, Mojgan; Dastgheib, Seyed Alireza; Abbasi, Hajar; Tabatabaiee, Razieh Sadat; Hadadan, Amaneh; Amjadi, Nooshin; Akbarian-Bafghi, Mohammad Javad; Neámatzadeh, Hossein

doi:10.1080/15513815.2019.1652379

Cited by 16 publications

(8 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The use of lymphocyte immunotherapy can substantially elevate the transformation rate of blocking antibodies in patients from negative to positive. The results of this study showed prominently higher levels of estrogen indicators of the experimental group than those of the control group (P < 0:05), which was consistent with the research results of Salimi et al [25] who pointed out that "after treatment, the indexes of estradiol, progesterone, and β-HCG in the experimental group were 138:81 ± 20:43, 32:33 ± 5:51, and 24:12 ± 4:35, respectively, and in the control group were 113:31 ± 46:72, 32:29 ± 5:54, and 24:09 ± 4:37, respectively. The estrogen indicators of the experimental group were significantly higher than those of the control group (P < 0:05)."…”

Section: Discussionsupporting

confidence: 92%

Effect of Prepregnancy Lymphocyte Active Immunotherapy on Unexplained Recurrent Miscarriage, Pregnancy Success Rate, and Maternal-Infant Outcome

Zhang

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

Objective. To evaluate the effect of prepregnancy lymphocyte active immunotherapy on unexplained recurrent miscarriage, pregnancy success rate, and maternal-infant outcome. Methods. A total of 124 patients with recurrent miscarriage admitted to our hospital from January 2018 to December 2020 were selected as the research objects and divided into the experimental group and the control group according to the random number table method, with 62 patients in each group. The experimental group was treated with lymphocyte active immunotherapy, and the control group was given conventional treatment. The pregnancy success rate, estrogen indexes, hemorheology indexes, and psychological state of the two groups were compared. Results. The experimental group garnered a notably higher pregnancy success rate and a prominently lower miscarriage rate than the control group ( P < 0.05 ). Better results of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were observed in the experimental group, as compared to the control group ( P < 0.05 ). The experimental group yielded more desirable results in terms of treatment satisfaction, estrogen indexes, and hemorheology indexes in comparison with the control group ( P < 0.05 ). Conclusion. The use of lymphocyte active immunotherapy for patients with unexplained recurrent miscarriage can significantly increase the pregnancy success rate, optimize the maternal-infant outcome, drive down the miscarriage rate, and ameliorate the patient’s estrogen levels and hemorheology indicators, which is worthy of promotion and application in clinical practice.

show abstract

Section: Discussionsupporting

confidence: 92%

Effect of Prepregnancy Lymphocyte Active Immunotherapy on Unexplained Recurrent Miscarriage, Pregnancy Success Rate, and Maternal-Infant Outcome

Zhang

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…The IL-12B gene is mapped to chromosome 5q31-33 and encodes the p40 subunit of interleukin 12 (Randolph et al, 2004). Moreover, IL-6 is a multipotent cytokine that regulates immune and inflammatory responses (Aflatoonian et al, 2019b;Salimi et al, 2019;Sheikhpour et al, 2017). Moreover, IL-6 has been considered as a "metabolic hormone" which affects metabolism of glucose, protein and lipids (Gholami et al, 2019).…”

Section: Association Of Il-12b Rs3212227 and Il-6 Rs1800795mentioning

confidence: 99%

“…Moreover, IL-6 has been considered as a "metabolic hormone" which affects metabolism of glucose, protein and lipids (Gholami et al, 2019). The human IL-6 gene is localized to chromosome 7p21-24, consists of seven exons and spanning 12.8 kb (Salimi et al, 2019).…”

Section: Association Of Il-12b Rs3212227 and Il-6 Rs1800795mentioning

confidence: 99%

Association of IL-12B rs3212227 and IL-6 rs1800795 Polymorphisms with Susceptibility to Cervical Cancer: A Systematic Review and Meta-Analysis

Karimi-Zarchi¹,

Abbasi²,

Javaheri³

et al. 2020

Asian Pac J Cancer Prev

Self Cite

View full text Add to dashboard Cite

Cervical cancer is the second most commonly diagnosed malignancy and third leading cause of cancer-related mortality among women in less developed countries (Karimi Zarchi et al., 2010; Mousavi et al., 2008). According to GLOBOCAN, cervical cancer accounts for 528,000 new cases and 266,000 deaths worldwide in 2012 (Parkin et al., 2005). Although, it has been widely accepted for several decades that Human papillomavirus (HPV) is the main risk factor for development of cervical cancer (Behtash et al., 2009; Farbod et al., 2019; Ghaemmaghami et al., 2008), HPV infections have developed to persistent infection in only a very few cases and it is sufficient to induce cervical cancer in an even smaller proportion

show abstract

“…On the other hand, the cytokine IL-6 has a protective role in immune responses against infections that caused by different bacteria and viruses. To cause an in ammatory reaction, pathogenic agents need access the intrauterine surroundings of the fetal tissues or endometrium, which can result in miscarriage [3,39]. Prasad et al investigated the role of Th1/Th2/Th17 cytokines in the immunopathogenesis process of miscarriage in Chlamydia trachomatis (Ct)-positive rst-trimester aborters [19,40].…”

Section: Discussionmentioning

confidence: 99%

Molecular Investigation of Association Among Common IL-6 Polymorphism with Cytomegalovirus(CMV) Infection and Recurrent Miscarriage in Iranian Women

Ardakani

Rahimi

Panahi

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Recurrent pregnancy loss (RPL) is described as two or more spontaneous abortions. Until now, although various factors such as genetic, endocrinology, anatomy, immunology, and microbiology have been distinguished that affect abortions, the precise basic etiology in up to 50% of RPL cases are not determined. Human cytomegalovirus (CMV) infection and host genetic background, like IL-6 SNP polymorphisms play important roles in RPL etiology. Objective: This study aimed to evaluate relationship among single nucleotide polymorphisms (-634C/G and -174 G/C) in the IL-6 gene with CMV infection and risk of RPL for early detection and treatment of RPL. Materials and methods: This case-control study was carried on 80 Iranian females with RPL and 80 healthy females as control group. The extraction of DNA from samples and detection of CMV and IL6 SNPs were determined by Tetra ARMS-PCR. Finally, the statistical analysis for detection CMV and two polymorphisms roles in RPL were analyzed by Epi Info TM software by X2 test. Results: Our results indicated an increased rate of CMV infection in RPL group (44%) versus the control group (25.45%). Also, the prevalence of IL-6 -634C/G genotype among RPL patients with CMV infection was 80%, while the frequency of this genotype among RPL patients without CMV infection was 50%. Furthermore, no substantial relation was found between IL-6 -174 G/C genotypes and RPL (P ≤0.0001). BesidesConclusion: This study not only indicated a significant role of CMV in RPL, but also showed CMV association with allele G in IL6 -634 among Iranian women. In addition, suggested the use of CMV and IL-6 -634 GG genotypes in RPL as diagnostic and prognostic biomarkers in Iranian population.

show abstract

Association of Promoter Region Polymorphisms of IL-6 and IL-18 Genes with Risk of Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis

Cited by 16 publications

References 27 publications

Effect of Prepregnancy Lymphocyte Active Immunotherapy on Unexplained Recurrent Miscarriage, Pregnancy Success Rate, and Maternal-Infant Outcome

Effect of Prepregnancy Lymphocyte Active Immunotherapy on Unexplained Recurrent Miscarriage, Pregnancy Success Rate, and Maternal-Infant Outcome

Association of IL-12B rs3212227 and IL-6 rs1800795 Polymorphisms with Susceptibility to Cervical Cancer: A Systematic Review and Meta-Analysis

Molecular Investigation of Association Among Common IL-6 Polymorphism with Cytomegalovirus(CMV) Infection and Recurrent Miscarriage in Iranian Women

Contact Info

Product

Resources

About