Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke

Bitencourt, Ana Carolina Silva; Timóteo, Rodolfo Pessato; Bazan, Rodrigo; Silva, Marcos; Filho, Luiz Gonzaga da Silveira; Ratkevicius, Cristhianne Molinero Andrade; Assunção, Thaís Soares Farnesi de; Oliveira, Ana Paula; Luvizutto, Gustavo José

doi:10.1016/j.jstrokecerebrovasdis.2021.106187

Cited by 5 publications

(4 citation statements)

References 52 publications

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“…In line with previously reported literature [5,29], we observed that inflammation is a key factor in the pathogenesis of stroke. In parallel to the profiling of patients by means of cytokine quantitation, as already reported in the literature for acute stroke, we evaluated microglia-derived EVs that significantly modify their presence in the blood of ischemic stroke patients in relation to the time spent between blood withdrawal and stroke event, even in the sub-acute phase of the disease.…”

Section: Discussionsupporting

confidence: 93%

“…These results are in accordance with literature findings on the increase in TNF-α serum levels of ischemic stroke patients as a part of the acute phase response that occurs during stroke pathogenesis [31,32]. Indeed, the neuroinflammatory response is a dynamic process and the levels of the soluble mediators are known to be fluctuant and strictly related to the observational time point [29], especially in the acute phase of the disease. As an example, it was previously reported that baseline levels of soluble FasL are lower immediately after ischemia compared to healthy controls, but they return to normal levels after 24 h [33].…”

Section: Discussionsupporting

confidence: 92%

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Multiplexing Biosensor for the Detection of Extracellular Vesicles as Biomarkers of Tissue Damage and Recovery after Ischemic Stroke

Picciolini

Mangolini

Rodà

et al. 2023

IJMS

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The inflammatory, reparative and regenerative mechanisms activated in ischemic stroke patients immediately after the event cooperate in the response to injury, in the restoration of functions and in brain remodeling even weeks after the event and can be sustained by the rehabilitation treatment. Nonetheless, patients’ response to treatments is difficult to predict because of the lack of specific measurable markers of recovery, which could be complementary to clinical scales in the evaluation of patients. Considering that Extracellular Vesicles (EVs) are carriers of multiple molecules involved in the response to stroke injury, in the present study, we have identified a panel of EV-associated molecules that (i) confirm the crucial involvement of EVs in the processes that follow ischemic stroke, (ii) could possibly profile ischemic stroke patients at the beginning of the rehabilitation program, (iii) could be used in predicting patients’ response to treatment. By means of a multiplexing Surface Plasmon Resonance imaging biosensor, subacute ischemic stroke patients were proven to have increased expression of vascular endothelial growth factor receptor 2 (VEGFR2) and translocator protein (TSPO) on the surface of small EVs in blood. Besides, microglia EVs and endothelial EVs were shown to be significantly involved in the intercellular communications that occur more than 10 days after ischemic stroke, thus being potential tools for the profiling of patients in the subacute phase after ischemic stroke and in the prediction of their recovery.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Multiplexing Biosensor for the Detection of Extracellular Vesicles as Biomarkers of Tissue Damage and Recovery after Ischemic Stroke

Picciolini

Mangolini

Rodà

et al. 2023

IJMS

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“…Clinical studies showed that, low levels of IL-10 are associated with a higher risk of hemorrhagic transformation or neurological deteriorations, whereas high levels with an increased risk of stroke-associated infections [ 23 ]. Furthermore, plasma levels of IL-10 are associated with the infarct size [ 24 ].…”

Section: Cytokinesmentioning

confidence: 99%

Inflammatory biomarkers of ischemic stroke

et al. 2023

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Ischemic stroke remains the second leading cause of death and among the major causes of morbidity worldwide. Therapeutic options are currently limited to early reperfusion strategies, while pharmacological neuroprotective strategies despite showing promising results in the experimental setting constantly failed to enter the clinical arena. Inflammation plays an important role in the pathophysiology of ischemic stroke and mediators of inflammation have been longtime investigated as possible prognostic marker and therapeutic target for stroke patients. Here, we summarized available evidence on the role of cytokines, soluble adhesion molecules and adipokines in the pathophysiology, prognosis and therapy of ischemic stroke.

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“…Levels of NSE, S100B protein, and neurofilament light chain may reflect the degree of neurological damage caused by stroke and have been demonstrated to correlate with stroke severity and infarct size [ 14 , 15 , 29 , 30 ]. Several proinflammatory and inflammatory cytokines—such as interleukin (IL)-6, IL-10, adhesion molecules, and circulating endothelial- or platelet-derived microparticles—have also been proposed as having associations with stroke severity and prognosis [ 15 , [31] , [32] , [33] ].…”

Section: Discussionmentioning

confidence: 99%

Beyond diagnosis: Leveraging routine blood and urine biomarkers to predict severity and functional outcome in acute ischemic stroke

Bamodu,

Chan,

et al. 2024

Heliyon

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Association of Proinflammatory Cytokine Levels with Stroke Severity, Infarct Size, and Muscle Strength in the Acute Phase of Stroke

Cited by 5 publications

References 52 publications

Multiplexing Biosensor for the Detection of Extracellular Vesicles as Biomarkers of Tissue Damage and Recovery after Ischemic Stroke

Multiplexing Biosensor for the Detection of Extracellular Vesicles as Biomarkers of Tissue Damage and Recovery after Ischemic Stroke

Inflammatory biomarkers of ischemic stroke

Beyond diagnosis: Leveraging routine blood and urine biomarkers to predict severity and functional outcome in acute ischemic stroke

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