Inflammatory biomarkers of ischemic stroke

Abstract

Ischemic stroke remains the second leading cause of death and among the major causes of morbidity worldwide. Therapeutic options are currently limited to early reperfusion strategies, while pharmacological neuroprotective strategies despite showing promising results in the experimental setting constantly failed to enter the clinical arena. Inflammation plays an important role in the pathophysiology of ischemic stroke and mediators of inflammation have been longtime investigated as possible prognostic marker and therapeutic target for stroke patients. Here, we summarized available evidence on the role of cytokines, soluble adhesion molecules and adipokines in the pathophysiology, prognosis and therapy of ischemic stroke.

Using a k-means clustering to identify novel phenotypes of acute ischemic stroke and development of its Clinlabomics models

“…Recent works have shown that inflammation plays a vital role in the pathogenesis of AIS, which may increase the risk of stroke and exacerbate ischemic lesions ( 37 – 39 ). When ischemia occurs in the cerebrum, peripheral circulating leukocytes and their subsets, including neutrophils, monocytes, and lymphocytes, are recruited to the cerebral ischemic region.…”

Ischemic stroke pathophysiology: A bibliometric and visualization analysis from 1990 to 2022

“…Over the past few decades, researchers have put enormous efforts into the research of ischemic stroke pathophysiology [ 23 ]. The number of publications related to this field was increasing year by year.…”

Beyond diagnosis: Leveraging routine blood and urine biomarkers to predict severity and functional outcome in acute ischemic stroke

“…Levels of NSE, S100B protein, and neurofilament light chain may reflect the degree of neurological damage caused by stroke and have been demonstrated to correlate with stroke severity and infarct size [ 14 , 15 , 29 , 30 ]. Several proinflammatory and inflammatory cytokines—such as interleukin (IL)-6, IL-10, adhesion molecules, and circulating endothelial- or platelet-derived microparticles—have also been proposed as having associations with stroke severity and prognosis [ 15 , [31] , [32] , [33] ].…”