Association of Preoperative US Features and Recurrence in Patients with Classic Papillary Thyroid Carcinoma

Kim, Soo Yeon; Kwak, Jin Young; Kim, Min Jung; Yoon, Jung Hyun; Moon, Hee Jung

doi:10.1148/radiol.2015142470

Cited by 54 publications

(51 citation statements)

References 40 publications

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“…After surgery, most patients need to be on treatment with thyroid hormone for the rest of their life. If the cancer is large and if it has spread to lymph nodes, treatment with radioactive iodine can be used after the thyroid gland removed [1][2][3].…”

Section: Discussionmentioning

confidence: 99%

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A Case of Papillary Thyroid Carcinoma Discovered by Elastography

Sarachi¹

2017

IJRRT

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We report a case of papillary thyroid carcinoma (PTC) discovered by elastography (E). A 54 years old female with a studied thyroid nodule during 5 years, was performed E. This study shown an inner area of stiffness, that was punctured. The cytology reported suspicious of papillary carcinoma. The E improves the diagnostic performance of ultrasound (US). It is an additional tool that helps guide fine-needle aspiration (FNA) and estimates preoperative malignancy risk.

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Section: Discussionmentioning

confidence: 99%

“…Thyroid stiffness index obtained with E is useful in differentiating between malignant and benign thyroid nodules. It is possible measure tissue deformation in response to compression, what give us an idea of tissue stiffness [1,2].…”

mentioning

confidence: 99%

A Case of Papillary Thyroid Carcinoma Discovered by Elastography

Sarachi¹

2017

IJRRT

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“…Previous investigators have found that malignant-appearing PTCs, i.e., PTCs that had at least one suspicious US feature, more frequently had aggressive prognostic factors than benign-appearing PTCs and that the presence of suspicious US features was independently associated with recurrence. [16,17] In one study, a greater number of suspicious US findings was associated with multifocality, extrathyroidal extension, lymph node metastasis, and a high stage. [16] Although the specific US features that are classified as suspicious by the TIRADS differ from the two prior studies, our results also support the potential role of US features as a prognostic tool in PTC.…”

Section: Discussionmentioning

confidence: 99%

“…[16,17] Recently, the thyroid imaging reporting and data system (TIRADS) by Kwak et al [18] which is based on the number of suspicious US features, has been shown to be accurate in malignancy risk stratification of thyroid nodules and simple to apply to clinical practice. However, its association with established prognostic factors in patients with PTC has not yet been examined.…”

Section: Introductionmentioning

confidence: 99%

The thyroid imaging reporting and data system on US, but not the BRAFV600E mutation in fine-needle aspirates, is associated with lateral lymph node metastasis in PTC

Park

Kim²,

Moon

et al. 2016

Medicine

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The majority of patients with papillary thyroid carcinoma (PTC) have an excellent prognosis, but some show poorer outcomes and would benefit from adjunctive prognostic tools. The B-Raf proto-oncogene, serine/threonine kinase (BRAF)V600E mutation, either based on both its presence or its quantitative measurement, and ultrasound (US) features may serve as a prognostic marker. The aim of this study was to investigate (1) the association between clinical-pathologic prognostic factors and the BRAFV600E mutation found in fine-needle aspirates, based on both its presence and its corresponding cycle threshold (Ct) value, and (2) the association between prognostic factors and suspicious US features classified by the thyroid imaging reporting and data system (TIRADS) in PTC.Two-hundred fifty-eight consecutive patients with PTC > 1 cm and who underwent preoperative US-guided fine-needle aspiration were included in this retrospective study. Clinical-pathologic variables were compared between patients with and without the BRAFV600E mutation. Multivariate analyses were performed to investigate (1) the association between clinical-pathologic prognostic factors and the BRAF V600Emutation found in fine-needle aspirates, based on both its presence and corresponding Ct values, and (2) the association between prognostic factors and suspicious TIRADS US features.BRAFV600E-positive patients had a higher proportion of multiple tumors (P = 0.017). The number of suspicious US features classified by the TIRADS was an independent factor for predicting lateral lymph node metastasis, both in all 258 patients (odds ratio [OR] = 1.902, P = 0.005) and in 214 BRAFV600E-positive patients (OR = 1.686, P = 0.037). The BRAFV600E mutation status or BRAFV600ECt values were not associated with any of the clinical-pathologic prognostic factors.In conclusion, a higher number of suspicious US features classified by the TIRADS, but not the BRAFV600E mutation, are associated with lateral lymph node metastasis in patients with PTC, and can aid in the preoperative identification of patients at increased risk of lateral lymph node metastasis.

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“…All patients in this study had been included in the study population of a previously published article. 16) However, the previous study had different research purposes from our own and did not deal with the same concepts.…”

Section: Patientsmentioning

confidence: 93%

Preoperative High Neutrophil-Lymphocyte Ratio May Be Associated with Lateral Lymph Node Metastasis in Patients with Papillary Thyroid Cancers

et al. 2018

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Background and Objectives:The present study investigated the association between preoperative neutrophilto-lymphocyte ratio (NLR) and poor prognostic outcomes in conventional papillary thyroid carcinomas (cPTCs). Materials and Methods: Two hundred and five patients who underwent total thyroidectomy for cPTCs larger than 10 mm were evaluated retrospectively. Patients were classified into the low NLR (n=103) and high NLR (n=102) groups by the median NLR value (1.78) and logistic regression analysis was used to evaluate whether the NLR predicted aggressive PTC features. Patients were also classified into the disease-free (n=183) and persistence/recurrence (n=22) groups and Cox regression analysis was used to investigate factors affecting persistence/recurrence by Cox regression analysis. Results: The high NLR group had a higher presence of lateral lymph node metastasis (p=0.004) and higher radioactive iodine doses (p=0.006) than the low NLR group. High NLR was an independent predictor of lateral lymph node metastasis (LNM) (OR, 2.786; p=0.005) but was not significantly associated with persistence/recurrence. Conclusion: Preoperative high NLR was an independent predictor of lateral LNM in cPTCs.

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Association of Preoperative US Features and Recurrence in Patients with Classic Papillary Thyroid Carcinoma

Abstract: The presence of malignant-appearing US features was independently associated with recurrence in patients with classic PTC.

Cited by 54 publications

References 40 publications

A Case of Papillary Thyroid Carcinoma Discovered by Elastography

A Case of Papillary Thyroid Carcinoma Discovered by Elastography

The thyroid imaging reporting and data system on US, but not the BRAFV600E mutation in fine-needle aspirates, is associated with lateral lymph node metastasis in PTC

Preoperative High Neutrophil-Lymphocyte Ratio May Be Associated with Lateral Lymph Node Metastasis in Patients with Papillary Thyroid Cancers

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