The thyroid imaging reporting and data system on US, but not the BRAFV600E mutation in fine-needle aspirates, is associated with lateral lymph node metastasis in PTC

Park, Vivian Youngjean; Kim, Min Jung; Moon, Hee Jung; Yoon, Jung Hyun; Kwak, Jin Young

doi:10.1097/md.0000000000004292

Cited by 17 publications

(10 citation statements)

References 31 publications

(49 reference statements)

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“…The association between US features classified by the thyroid imaging reporting and data system (TIRADS) and cervical LMN was also explored. In a study carried out by Park et al ( 40 ), it was found that the number of suspicious TIRADS US features was associated with lateral LMN in PTC. However, to our knowledge, no previous studies have addressed the relationship between thyroid parenchymal US features and cervical LNM.…”

Section: Discussionmentioning

confidence: 96%

Thyroid Parenchyma Microcalcifications on Ultrasound for Predicting Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Prospective Multicenter Study in China

Liu

Jia

et al. 2021

Front. Oncol.

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Objective: Cervical lymph node metastasis (LNM) was found to be clinically significant prognostic factors of patients with papillary thyroid carcinomas (PTC). Ultrasound (US) characteristics of thyroid nodules and thyroid parenchyma may be used to predict LNM. To investigate the value of nodular US features as well as thyroid parenchymal microcalcifications on US in predicting LNM in patients with PTC.Methods: This prospective study was approved by the Institutional Review Board. From January 2018 to June 2019, 971 consecutive patients with solitary PTC who underwent preoperative neck US evaluation were included from six hospitals in China. The US features of thyroid nodules as well as thyroid parenchyma microcalcifications were carefully evaluated based on the static images and dynamic clips. Univariate and multivariate analyses were performed to determine independent predictors of LNM.Results: Of the 971 patients, 760 were female, 211 were male. According to the pathological examination, 241(24.82%) patients were found with cervical LNM (LNM positive group), while 730 (75.18%) patients were not (LNM negative group). Multiple logistic regression analysis showed that young age (<55 years old) (OR = 1.522, P = 0.047), large size (>10 mm) (OR = 1.814, P < 0.001), intratumoral microcalcifications (OR = 1.782, P = 0.002) and thyroid parenchyma microcalcifications (OR = 1.635, P = 0.046) were independent risk factors for LNM of PTC.Conclusions: Young age, large nodule size, intratumoral microcalcifications, as well as thyroid parenchyma microcalcifications on US are independent predictors of cervical LNM for patients with PTC.

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Section: Discussionmentioning

confidence: 96%

Thyroid Parenchyma Microcalcifications on Ultrasound for Predicting Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Prospective Multicenter Study in China

Liu

Jia

et al. 2021

Front. Oncol.

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“…Evaluation results for lateral cervical lymph nodes vary the most among physicians, with the reported positive predictive values ranging from 38.5% to 64% according to different levels of experience [10]. Previous research has also focused on US or the pathologic features of the primary thyroid tumor itself, and has reported that a high suspicion US pattern, upper pole location, extrathyroidal extension, presence of calcifications, and central LNM are associated with lateral LNM [19][20][21]. However, such qualitative imaging features are also based on the judgment of the performing physician and therefore, prone to interobserver variability.…”

Section: Discussionmentioning

confidence: 99%

Radiomics signature for prediction of lateral lymph node metastasis in conventional papillary thyroid carcinoma

et al. 2020

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Preoperative neck ultrasound (US) for lateral cervical lymph nodes is recommended for all patients undergoing thyroidectomy for thyroid malignancy, but it is operator dependent. We aimed to develop a radiomics signature using US images of the primary tumor to preoperatively predict lateral lymph node metastasis (LNM) in patients with conventional papillary thyroid carcinoma (cPTC). Methods Four hundred consecutive cPTC patients from January 2004 to February 2006 were enrolled as the training cohort, and 368 consecutive cPTC patients from March 2006 to February 2007 served as the validation cohort. A radiomics signature, which consisted of 14 selected features, was generated by the least absolute shrinkage and selection operator (LASSO) regression model in the training cohort. The discriminating performance of the radiomics signature was assessed in the validation cohort with the area under the receiver operating characteristic curve (AUC). Results The radiomics signature was significantly associated with lateral cervical lymph node status (p < 0.001). The AUC of its performance in discriminating metastatic and non-metastatic lateral cervical lymph nodes was 0.710 (95% CI: 0.649-0.770) in the training cohort and was 0.621 (95% CI: 0.560-0.682) in the validation cohort. Conclusions The present study showed that US radiomic features of the primary tumor were associated with lateral cervical lymph node status. Although their discriminatory performance was

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“…PTC with suspicious US features more frequently had lymph node metastasis at diagnosis and recurrence than PTC without suspicious US features [ 32 , 34 ]. Moreover, higher number of suspicious US features were associated with lymph node metastasis in patients with PTC [ 33 ]. In a study by Kwak et al [ 17 ], upper pole location, minimal extrathyroidal extension on US (> 25% contact with the adjacent capsule), and the presence of calcifications were the independent predictors of lateral lymph node metastasis in patients with PTMC.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound texture analysis: Association with lymph node metastasis of papillary thyroid microcarcinoma

Kim¹,

Lee²,

Nam³

et al. 2017

PLoS ONE

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This retrospective study aimed to evaluate whether ultrasound texture analysis is useful to predict lymph node metastasis in patients with papillary thyroid microcarcinoma (PTMC).This study was approved by the Institutional Review Board, and the need to obtain informed consent was waived. Between May and July 2013, 361 patients (mean age, 43.8 ± 11.3 years; range, 16–72 years) who underwent staging ultrasound (US) and subsequent thyroidectomy for conventional PTMC ≤ 10 mm between May and July 2013 were included. Each PTMC was manually segmented and its histogram parameters (Mean, Standard deviation, Skewness, Kurtosis, and Entropy) were extracted with Matlab software. The mean values of histogram parameters and clinical and US features were compared according to lymph node metastasis using the independent t-test and Chi-square test. Multivariate logistic regression analysis was performed to identify the independent factors associated with lymph node metastasis. Tumors with lymph node metastasis (n = 117) had significantly higher entropy compared to those without lymph node metastasis (n = 244) (mean±standard deviation, 6.268±0.407 vs. 6.171±.0.405; P = .035). No additional histogram parameters showed differences in mean values according to lymph node metastasis. Entropy was not independently associated with lymph node metastasis on multivariate logistic regression analysis (Odds ratio, 0.977 [95% confidence interval (CI), 0.482–1.980]; P = .949). Younger age (Odds ratio, 0.962 [95% CI, 0.940–0.984]; P = .001) and lymph node metastasis on US (Odds ratio, 7.325 [95% CI, 3.573–15.020]; P < .001) were independently associated with lymph node metastasis. Texture analysis was not useful in predicting lymph node metastasis in patients with PTMC.

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The thyroid imaging reporting and data system on US, but not the BRAFV600E mutation in fine-needle aspirates, is associated with lateral lymph node metastasis in PTC

Cited by 17 publications

References 31 publications

Thyroid Parenchyma Microcalcifications on Ultrasound for Predicting Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Prospective Multicenter Study in China

Thyroid Parenchyma Microcalcifications on Ultrasound for Predicting Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Prospective Multicenter Study in China

Radiomics signature for prediction of lateral lymph node metastasis in conventional papillary thyroid carcinoma

Ultrasound texture analysis: Association with lymph node metastasis of papillary thyroid microcarcinoma

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