Association of Pregnancy-Induced Hypertension With Duration of Sexual Cohabitation Before Conception

Robillard, Pierre‐Yves; Hulsey, Thomas C.; Périanin, J; Janky, E.; Miri, El Habib; Papiernik, E

doi:10.1097/00006254-199504000-00003

Cited by 44 publications

(46 citation statements)

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“…15 These findings support the immunologic theory of preeclampsia stating the primo movens of pre-eclampsia is rejection of sperm cells by the mother's immune system after a short period of sexual cohabitation. 16 Right upper abdominal quadrant pain (aOR: 9.9; 95% CI: 1.2-77.9), headache (uOR: 2.9; 95%CI: 1.4-6.2) and (aOR: 7.9; 95% CI: 2.3-26.9) visual disturbances were associated with eclampsia in our series. Salem B et al reported similar findings.…”

Section: Predictors Of Eclampsia Among Pre-eclamptic Patientsmentioning

confidence: 47%

Predictors of eclampsia among preeclamptic patients: a case control study in Yaounde, Cameroon

Fouedjio¹,

Foumane

Fouogue

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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Section: Predictors Of Eclampsia Among Pre-eclamptic Patientsmentioning

confidence: 47%

Predictors of eclampsia among preeclamptic patients: a case control study in Yaounde, Cameroon

Fouedjio¹,

Foumane

Fouogue

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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“…Finally, we classified pregnancies according to maternal ethnicity but were unable to account for paternity. While paternal factors have been linked to altered preeclampsia risk in some but not all prior studies (43)(44)(45), there is minimal data regarding the effects of paternal race-ethnicity.…”

Section: Discussionmentioning

confidence: 99%

Differential Risk of Hypertensive Disorders of Pregnancy among Hispanic Women

Wolf¹,

Shah

Jimenez-Kimble³

et al. 2004

Journal of the American Society of Nephrology

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Abstract. Preeclampsia and gestational hypertension are leading complications of pregnancy that also portend increased risk of future chronic hypertension. Although rates of chronic hypertension differ between non-Hispanic Caucasian and Hispanic women, few studies examined their relative rates of hypertensive disorders of pregnancy. The purpose of this study was to compare the risk of preeclampsia and gestational hypertension in a prospective cohort of normotensive, nulliparous Hispanic (n ϭ 863) and non-Hispanic Caucasian women (n ϭ 2,381). Compared with non-Hispanic Caucasian women, Hispanic women demonstrated a significantly decreased incidence of gestational hypertension (1.6% versus 8.5%; P Ͻ 0.01), but a similar incidence of preeclampsia (3.8% versus 3.7%; P ϭ 0.9). Adjusting for age, smoking, diabetes, BP, body mass index (BMI), and multiple gestation uncovered an increased relative risk (RR) for preeclampsia among Hispanic women (RR 1.9; 95% CI, 1.1 to 3.3; P ϭ 0.01), while their relative risk for gestational hypertension remained significantly decreased (RR 0.39; 95% CI, 0.22 to 0.72; P Ͻ 0.01). Among women who initially presented with hypertension during pregnancy, Hispanic women were over threefold (hazard ratio 3.3; 95% CI, 1.9 to 6.0; P Ͻ 0.01) more likely to develop preeclampsia than non-Hispanic Caucasian women. Besides Hispanic ethnicity, baseline BP, BMI, diabetes, and multiple gestation were independent risk factors for preeclampsia, whereas only baseline BP and BMI were associated with gestational hypertension. Socioeconomic status and access to prenatal care were not associated with either disorder. Hispanic ethnicity is independently associated with increased risk for preeclampsia and decreased risk for gestational hypertension. The initial presentation of hypertension during pregnancy in Hispanic women most likely represents early preeclampsia.The hypertensive disorders of pregnancy, preeclampsia, and gestational hypertension, which complicate 6 to 8% of pregnancies (1), are leading causes of maternal and fetal morbidity and mortality, and are associated with increased risk of future chronic hypertension (2). Although the characteristic placental pathology of preeclampsia is established during early pregnancy (3), there are no reliable tools for early clinical diagnosis and no effective therapies to prevent disease or improve maternal and fetal outcomes. Importantly, there are also no means to differentiate whether the new onset of hypertension during pregnancy represents gestational hypertension or preeclampsia in which proteinuria has yet to develop. More fundamentally, it remains unclear if preeclampsia and gestational hypertension represent ends of a single pathophysiological spectrum of pregnancy-induced hypertension or distinct disorders with unique biological pathways and differential risk factor profiles.Risk factors for preeclampsia have been studied extensively as preeclampsia is the hypertensive disorder of pregnancy most commonly associated with devastating complications. Nullip...

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“…Human studies show that both acute exposure to semen at the beginning of a pregnancy, as well as cumulative exposure over time, can protect against recurrent miscarriage and preeclampsia, in a partner specific manner [101]. Studies have also shown that semen exposure in women is advantageous to pregnancy outcome, the use of barrier contraception methods and the period of cohabitation between couples suggests that chronic semen exposure by an individual can be beneficial to subsequent pregnancies [102]. There is now a large body of evidence to suggest that preeclampsia has male factors, derived from semen, involved in its aetiology [103,104].…”

Section: Seminal Plasma and Pathologies Of Pregnancymentioning

confidence: 99%

Seminal fluid and reproduction: much more than previously thought

Bromfield

2014

J Assist Reprod Genet

118

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The influence of seminal plasma on the cytokine and immune uterine environment is well characterised in mice and humans, while the effects of disruption to uterine seminal plasma exposure on pregnancy and offspring health is becoming more clearly understood. The cellular and molecular environment of the uterus during the pre-and peri-implantation period of early pregnancy is critical for implantation success and optimal foetal and placental development. Perturbations to this environment not only have consequences for the success of pregnancy and neonatal health and viability, but can also drive adverse health outcomes in the offspring after birth, particularly the development of metabolic disorders such as obesity, hypertension and insulin resistance. It is now reported that an absence of seminal plasma at conception in mice promotes increased fat accumulation, altered metabolism and hypertension in offspring. The evidence reviewed here demonstrates that seminal plasma is not simply a transport medium for sperm, but acts also as a key regulator of the female tract environment providing optimal support for the developing embryo and benefiting future health of offspring.

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Association of Pregnancy-Induced Hypertension With Duration of Sexual Cohabitation Before Conception

Cited by 44 publications

References 0 publications

Predictors of eclampsia among preeclamptic patients: a case control study in Yaounde, Cameroon

Predictors of eclampsia among preeclamptic patients: a case control study in Yaounde, Cameroon

Differential Risk of Hypertensive Disorders of Pregnancy among Hispanic Women

Seminal fluid and reproduction: much more than previously thought

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