Association of Powder Use in the Genital Area With Risk of Ovarian Cancer

O’Brien, Katie M.; Tworoger, Shelley S.; Harris, Holly R.; Anderson, Garnet L.; Weinberg, Clarice R.; Trabert, Britton; Kaunitz, Andrew M.; D’Aloisio, Aimee A.; Sandler, Dale P.; Wentzensen, Nicolas

doi:10.1001/jama.2019.20079

Cited by 49 publications

(45 citation statements)

References 25 publications

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“…[ 182 ]. Apart from the contamination of talc with asbestos until the end of the 1970s and beyond [ 183 , 184 ], the presence of tainted talc in commercially available powder formulations has varied over time in various brands of products, resulting in difficulties for epidemiological studies to define an ascertained genital talc exposure [ 185 ] and to avoid statistical bias [ 186 ].…”

Section: Discussionmentioning

confidence: 99%

“…The type and number of fibers that could potentially be inhaled during normal use of talcum powder were found to be superimposable on those detected in the lung tissue of a woman who died of mesothelioma. The debate sparked by this paper led to several works focusing on this topic until last year with controversial results [ 35 , 37 , 184 , 215 , 216 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 224 ]. For example, it should be emphasized that no excesses of pleural mesothelioma nor talc pneumoconiosis were found in studies of miners in talc mines [ 177 , 225 , 226 , 227 , 228 ].…”

Section: Discussionmentioning

confidence: 99%

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Primary Ovarian Mesothelioma: A Case Series with Electron Microscopy Examination and Review of the Literature

Vimercati

Cavone

Delfino

et al. 2021

Cancers

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Primary ovarian mesothelioma is a rare, aggressive neoplastic disease with a poor prognosis. At onset, the tumor is only rarely limited to the ovaries and usually already widespread in the peritoneum. The rarity of this entity and the difficulties differentiating it from either ovarian carcinoma or peritoneal mesothelioma may lead to frequent misdiagnoses and may raise some concerns about its histogenesis. Thus, reporting such rare cases is fundamental to gain greater awareness of this neoplasm and try to answer unsolved questions. Herein, we described four cases of histological diagnoses of ovarian mesothelioma extrapolated by the regional mesothelioma register of Apulia (southern Italy). In all cases, a detailed medical history was collected according to national mesothelioma register guidelines. A broad panel of antibodies was used for immunohistochemistry to confirm the diagnoses. Moreover, ovarian tissue samples were also examined by transmission and scanning electron microscopy, detecting asbestos fibers and talc crystals in two cases. Because of the few cases described, we reviewed the English literature in the Medline database, focusing on articles about ovarian mesothelioma “misclassification”, “misdiagnosis”, “diagnostic challenge” or “diagnostic pitfall” and on unsolved questions about its histogenesis and possible risk factors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary Ovarian Mesothelioma: A Case Series with Electron Microscopy Examination and Review of the Literature

Vimercati

Cavone

Delfino

et al. 2021

Cancers

View full text Add to dashboard Cite

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“…Another example is the use of powdered talc in the genital area. This chemical may alter the microenvironment subsequently elevating the risk of cancer [ 47 ]. Finally, in observational studies patients with ovarian cancer or predisposition for ovarian cancer (germline BRCA1 mutation) were associated with a specific microbiome in the vagina/cervix [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Bacterial, Archaea, and Viral Transcripts (BAVT) Expression in Gynecological Cancers and Correlation with Regulatory Regions of the Genome

Bosquet

Pedra-Nobre

Devor

et al. 2021

Cancers

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Bacteria, archaea, and viruses are associated with numerous human cancers. To date, microbiome variations in transcription have not been evaluated relative to upper female genital tract cancer risk. Our aim was to assess differences in bacterial, archaea, and viral transcript (BAVT) expression between different gynecological cancers and normal fallopian tubes. In this case-control study we performed RNA sequencing on 12 normal tubes, 112 serous ovarian cancers (HGSC) and 62 endometrioid endometrial cancers (EEC). We used the centrifuge algorithm to classify resultant transcripts into four indexes: bacterial, archaea, viral, and human genomes. We then compared BAVT expression from normal samples, HGSC and EEC. T-test was used for univariate comparisons (correcting for multiple comparison) and lasso for multivariate modelling. For validation we performed DNA sequencing of normal tubes in comparison to HGSC and EEC BAVTs in the TCGA database. Pathway analyses were carried out to evaluate the function of significant BAVTs. Our results show that BAVT expression levels vary between different gynecological cancers. Finally, we mapped some of these BAVTs to the human genome. Numerous map locations were close to regulatory genes and long non-coding RNAs based on the pathway enrichment analysis. BAVTs may affect gynecological cancer risk and may be part of potential targets for cancer therapy.

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“…Unconvincing data have been obtained for the association between powder use in the genital area and the risk of ovarian cancer. In this context, some studies highlighted a slightly increased risk of ovarian cancer in women using talc powder in the genital area ( 28 - 30 ). However, a recent observational study on 250,000 women observed for 11 years has demonstrated that the use of powder does not significantly increase the incidence of ovarian cancer ( 28 - 30 ).…”

Section: Risk and Protective Factors For Ovarian Cancermentioning

confidence: 99%

A multidisciplinary approach remains the best strategy to improve and strengthen the management of ovarian cancer (Review)

et al. 2021

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Ovarian cancer represents one of the most aggressive female tumors worldwide. Over the decades, the therapeutic options for the treatment of ovarian cancer have been improved significantly through the advancement of surgical techniques as well as the availability of novel effective drugs able to extend the life expectancy of patients. However, due to its clinical, biological and molecular complexity, ovarian cancer is still considered one of the most difficult tumors to manage. In this context, several studies have highlighted how a multidisciplinary approach to this pathology improves the prognosis and survival of patients with ovarian cancer. On these bases, the aim of the present review is to present recent advantages in the diagnosis, staging and treatment of ovarian cancer highlighting the benefits of a patient-centered care approach and on the importance of a multidisciplinary team for the management of ovarian cancer.

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Association of Powder Use in the Genital Area With Risk of Ovarian Cancer

Abstract: Importance:The relationship between genital powder use and ovarian cancer is not established. Positive associations reported in case-control studies have not been confirmed in cohort studies.

Cited by 49 publications

References 25 publications

Primary Ovarian Mesothelioma: A Case Series with Electron Microscopy Examination and Review of the Literature

Primary Ovarian Mesothelioma: A Case Series with Electron Microscopy Examination and Review of the Literature

Bacterial, Archaea, and Viral Transcripts (BAVT) Expression in Gynecological Cancers and Correlation with Regulatory Regions of the Genome

A multidisciplinary approach remains the best strategy to improve and strengthen the management of ovarian cancer (Review)

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