Association of Postural Sway with Disability Status and Cerebellar Dysfunction in People with Multiple Sclerosis

McLoughlin, James A.; Barr, Christopher; Crotty, Maria; Lord, Stephen R.; Sturnieks, Daina L.

doi:10.7224/1537-2073.2014-003

Cited by 29 publications

(22 citation statements)

References 45 publications

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“…Indeed, the differences between groups in Romberg Indices recorded during NPT, were lost in PT. In particular, we found a higher R SP for MS than healthy subjects in NPT, indicating that MS patients showed a compromised balance control after the withdrawal of visual stimuli; analogous reports were recently provided [50]. This result, however, was not mirrored by an analogous R CEA difference between the two groups.…”

Section: Discussionsupporting

confidence: 73%

Quantification of postural stability in minimally disabled multiple sclerosis patients by means of dynamic posturography: an observational study

Grassi

Rossi

Studer

et al. 2017

J NeuroEngineering Rehabil

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BackgroundMultiple Sclerosis (MS) is a widespread progressive neurologic disease with consequent impairments in daily activities. Disorders of balance are frequent and equilibrium tests are potentially useful to quantify disability and to verify treatment effectiveness. The fair sensitivity of the widely used not-perturbed tests to detect balance disturbances in MS patients have prompted the development of mechatronic systems capable to impose known equilibrium perturbations, in order to challenge the balance control and, consequently, to better assess the level of impairment. We sought to clarify whether the proposed perturbed-test is capable to discriminate healthy subjects from patients with MS, even in mild or in the absence of clinically evident balance disturbances.MethodsWe assessed balance performances of 17 adults with MS and 13 age-matched healthy controls (HC) using both perturbed (PT) and not-perturbed (NPT) postural tests by means of a 3 Degree Of Freedom (DOF) rotational mechatronic platform. Participants stood barefoot on the platform in standing position and their center of pressure (CoP) was gathered by using a pressure matrix. Each trial lasted 30 s and was carried out with and without visual stimuli. Several postural indices were computed for each trial. Correlations between postural indices and clinical scales were analyzed.ResultsNo significant differences were found between groups for all indices when subjects performed NPTs. Conversely, significant differences in postural indices between MS and HC emerged during PTs. Additionally, PTs revealed significant differences between patients without any cerebellar impairment (cerebellar EDSS subscore equal to 0) and HC. The discrimination capability of PTs was confirmed by the ROC analysis. No significant change of the selected metrics occurred in HC when NPTs were performed with eyes closed, while indices presented a significant worsening in MS subjects.ConclusionsNot-perturbed tests showed lower sensitivity than perturbed ones in the identification of equilibrium impairments in minimally disabled MS patients. However, not-perturbed tests allow to better evaluate the influence of visual flow disturbances on balance control in MS. In conclusion, our findings proved that the use of the novel tests based on a 3DOF mechatronic device represents an effective tool to investigate early balance disturbances in MS.

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Section: Discussionsupporting

confidence: 73%

Quantification of postural stability in minimally disabled multiple sclerosis patients by means of dynamic posturography: an observational study

Grassi

Rossi

Studer

et al. 2017

J NeuroEngineering Rehabil

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“…Measures including time to contact boundaries [25,57], loading asymmetry [28,57], trunk sway [58], centre of gravity measures [36,50,62] and sway path [43] were shown to be significantly altered in pwMS in comparison to healthy controls.…”

Section: Quiet Stancementioning

confidence: 92%

“…The overall methodological quality of the included studies was varied with total scores ranging from three to nine stars out of a possible nine stars. Only one study [18] satisfied the criteria of non-response rate reporting under the exposure category, while only five studies [18,24,43,48,49] provided adequate information relating to case population selection, highlighting a particular concern regarding the possibility of selection bias.…”

Section: Accepted Manuscript Quality Assessmentmentioning

confidence: 99%

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Postural control deficits in people with Multiple Sclerosis: A systematic review and meta-analysis

et al. 2018

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“…Traditionally, expensive specialized equipment such as force plates (Prado et al, 2007) or three-dimensional motion analyzers (McLoughlin, Barr, Crotty, Lord & Sturnieks, 2015) has been used for quantitative kinematic measurements of body sway, but more economic and userfriendly equipment such as Kinect Sensor (Microsoft, USA) and Wii Balance Board (WBB; Nintendo, Japan) has been gaining popularity in recent years. Depending on specific standing motions, Kinect provides a relatively accurate location of anatomical joint centers (AJC) by using depth sensors and red green blue (RGB) sensors, while WBB provides information on the center of pressure (COP).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Standing Balance of the Elderly with Different Balance Abilities by using Kinect and Wii Balance Board

Yang¹,

Seo²,

Kim³

et al. 2016

Korean Journal of Sport Biomechanics

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Objective: This study aimed to evaluate and identify variables for the standing balance of elderly subjects with different balancing abilities by using Kinect and Wii Balance Board.Method: The Berg Balance Scale (BBS) test was performed in 40 elderly subjects aged ≥65 years who can perform daily activities. The participants were divided into two groups, the healthy seniors (n = 20, BBS score ≥ 52) and the seniors with balancing problems (n = 20, BBS score < 52). Each group performed two standing tests (eyes open and eyes close) with two devices (Kinect and Wii Balance Board). The root mean square (RMS), mean distance (MDIST), range of distance (ROD), mean velocity, and 95% ellipse area were calculated from the measured data.Results: Among the calculated variables, RMS, MDIST, and ROD in the mediolateral direction showed significant differences between the two groups and a negative correlation with BBS scores. Conclusion:The results of the present study show that simple standing balance of the elderly can be measured with Kinect and Wii Balance Board, which are low-cost, easy to carry, and easy to use, by using the selected variables.

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Association of Postural Sway with Disability Status and Cerebellar Dysfunction in People with Multiple Sclerosis

Cited by 29 publications

References 45 publications

Quantification of postural stability in minimally disabled multiple sclerosis patients by means of dynamic posturography: an observational study

Quantification of postural stability in minimally disabled multiple sclerosis patients by means of dynamic posturography: an observational study

Postural control deficits in people with Multiple Sclerosis: A systematic review and meta-analysis

Evaluation of Standing Balance of the Elderly with Different Balance Abilities by using Kinect and Wii Balance Board

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