Association of Polymorphisms in three pri-miRNAs that Target Pepsinogen C with the Risk and Prognosis of Gastric Cancer

Wu, Yefeng; Xu, Qian; He, Caiyun; Li, Ying; Liu, Jingwei; Deng, Na; Sun, Liping; Yuan, Yuan

doi:10.1038/srep39528

Cited by 18 publications

(14 citation statements)

References 45 publications

(55 reference statements)

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“…Disruption of miRNA-mRNA binding may contribute to the development of different types of human diseases. This disruption may result from gene polymorphism at the miRNA target site [34][35][36], or polymorphism in miRNA genes [27,29,30,[37][38][39][40][41].…”

Section: Introductionmentioning

confidence: 99%

Potential Impact of MicroRNA Gene Polymorphisms in the Pathogenesis of Diabetes and Atherosclerotic Cardiovascular Disease

Elfaki

Mir

et al. 2019

JPM

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MicroRNAs (miRNAs) are endogenous, small (18–23 nucleotides), non-coding RNA molecules. They regulate the posttranscriptional expression of their target genes. MiRNAs control vital physiological processes such as metabolism, development, differentiation, cell cycle and apoptosis. The control of the gene expression by miRNAs requires efficient binding between the miRNA and their target mRNAs. Genome-wide association studies (GWASs) have suggested the association of single-nucleotide polymorphisms (SNPs) with certain diseases in various populations. Gene polymorphisms of miRNA target sites have been implicated in diseases such as cancers, diabetes, cardiovascular and Parkinson’s disease. Likewise, gene polymorphisms of miRNAs have been reported to be associated with diseases. In this review, we discuss the SNPs in miRNA genes that have been associated with diabetes and atherosclerotic cardiovascular disease in different populations. We also discuss briefly the potential underlining mechanisms through which these SNPs increase the risk of developing these diseases.

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Section: Introductionmentioning

confidence: 99%

Potential Impact of MicroRNA Gene Polymorphisms in the Pathogenesis of Diabetes and Atherosclerotic Cardiovascular Disease

Elfaki

Mir

et al. 2019

JPM

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“…In cervical cancer, miR-125a suppresses tumour growth, invasion and metastasis by targeting STAT3. In 2016, Xu et al [57] reported that the AA genotype of rs8111742 in miR-125a increased the risk for gastric cancer associated with H. pylori, and this same effect was found by Wu et al [58] in the H. pylori-positive group. SNP rs999885, located at the promoter region of the miR-106b-25 cluster, has been reported to be associated with the risk for hepatocellular carcinoma [59].…”

Section: Discussionmentioning

confidence: 64%

Polymorphisms in miRNA genes play roles in the initiation and development of cervical cancer

Zhang¹,

Zhou²,

Li³

et al. 2019

J. Cancer

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MicroRNA deregulation is crucial for cancer development. Studies showed that polymorphisms in miRNA genes could affect miRNA expression, which might be associated with cancer development. In the current study, we investigated the association of seven single nucleotide polymorphisms (SNPs) in seven miRNA genes with the initiation and development of cervical cancer in a Chinese Han population. The SNPs of 358 cervical intraepithelial neoplasia (CIN) patients, 547 cervical cancer patients and 567 healthy individuals were genotyped using TaqMan assays. Moreover, we evaluated the association of the seven SNPs with the different stages of cervical cancer. Our results showed that rs4636297 in miR-126 was associated with susceptibility to CIN and cervical cancer (P=0.019 and 0.019, respectively) and that the T allele was associated with a higher risk of CIN (OR=1.334, 95% CI: 1.049-1.698) and cervical cancer (OR=1.296, 95% CI: 1.044-1.609). Similarly, rs11614913 in miR-125a was associated with CIN and cervical cancer (P=0.025 and 0.015, respectively), and the T allele might be the protective factor for CIN (OR=0.807, 95% CI: 0.669-0.974) and cervical cancer (OR=0.814, 95% CI: 0.689-0.961). Our results indicated that rs4636297 in miR-126 and rs11614913 in miR-196a2 play an important role only in the initiation of cervical cancer not in the development of CIN to cervical cancer.

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“…PGC can also interact with polymorphisms in miRNAs that target it, including let‐7e, miR‐4795, and miR‐365b. They can bind to the 3′‐UTR region of PGC and inhibit its expression . Our study first reported the SNP interactions of PGC with its neighbor lncRNAs could also affect PGC expression.…”

Section: Discussionmentioning

confidence: 76%

“…They can bind to the 3′-UTR region of PGC and inhibit its expression. 35 Our study first reported the SNP interactions of PGC with its neighbor lncRNAs could also affect PGC expression. PGC protein is a well-known marker for the differentiation of gastric epithelial cells.…”

Section: Discussionmentioning

confidence: 89%

SNP interactions of PGC with its neighbor lncRNAs enhance the susceptibility to gastric cancer/atrophic gastritis and influence the expression of involved molecules

Sun

et al. 2018

Cancer Medicine

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Multidimensional interactions of multiple factors are more important in promoting cancer initiation. Gene‐gene interactions between protein‐coding genes have been paid great attention, while rare studies refer to the interactions between encoding and noncoding genes. Our research group previously found encoding gene PGC polymorphisms could affect the susceptibility to atrophic gastritis (AG) and gastric cancer (GC). Interestingly, several SNPs in long noncoding RNA (lncRNA) genes, just adjacent to PGC, were found to be associated with AG risk and GC prognosis afterward. This study aims to explore the SNP interactions between PGC and its neighbor lncRNAs on the risk of AG and GC. Genotyping for seven PGC SNPs and seven lncRNA SNPs was conducted using Sequenom MassARRAY platform in a total of 2228 northern Chinese subjects, including 536 GC cases, 810 AG cases, and 882 controls. We found 15 pairwise PGC‐lncRNAs SNPs had interactions: Five pairs were associated with AG risk, and ten pairs were associated with GC risk. Moreover, two GC‐related interactions PGC rs6939861 with lnc‐C6orf‐132‐1 rs7749023 and rs7747696 survived the Bonferroni correction (P correction = 0.049 and 0.007, respectively). Several combinations showed obvious epistasis and cumulative effects on disease risk. Some three‐way interactions of SNPs with smoking and drinking could also be observed. Besides, a few interacting SNPs showed correlations with the expression levels of PGC protein and related lncRNAs in serum. Our study would provide research clues for further screening combination biomarkers uniting both protein‐coding and noncoding genes with the potential in prediction of the susceptibility to GC and its precursor.

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Association of Polymorphisms in three pri-miRNAs that Target Pepsinogen C with the Risk and Prognosis of Gastric Cancer

Cited by 18 publications

References 45 publications

Potential Impact of MicroRNA Gene Polymorphisms in the Pathogenesis of Diabetes and Atherosclerotic Cardiovascular Disease

Potential Impact of MicroRNA Gene Polymorphisms in the Pathogenesis of Diabetes and Atherosclerotic Cardiovascular Disease

Polymorphisms in miRNA genes play roles in the initiation and development of cervical cancer

SNP interactions of PGC with its neighbor lncRNAs enhance the susceptibility to gastric cancer/atrophic gastritis and influence the expression of involved molecules

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