Association of polymorphisms in the genes of the urokinase plasminogen activation system with susceptibility to and severity of non-small cell lung cancer

Shih, Chuen-Ming; Kuo, Wu‐Hsien; Lin, Chiao‐Wen; Chen, Wei; Chen, Shuo-Chueh; Lee, Yao-Ling

doi:10.1016/j.cca.2010.10.004

Cited by 12 publications

(9 citation statements)

References 45 publications

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“…The possibility that the relationship between the uPA/uPAR genotypes with NSCLC susceptibility in the study is an ethnic-dependent observation cannot be entirely excluded because multiple risk factors and etiology contribute to the pathophysiology of NSCLC development. Our results are not in agreement with those found in a study by Chuen-Ming Shih [10] . Together with earlier studies [27][28][29] , these differences may primarily be attributed to the different living environments.…”

Section: Discussioncontrasting

confidence: 99%

Association Between the Urokinase Plasminogen Activation System Polymorphisms and NSCLC in Chinese Population

Zhang¹,

Gu²,

Shen³

2016

IJCO

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Aim: To evaluate the influence of uPA and uPAR gene polymorphisms in the susceptibility to NSCLC. Methods: A total of 500 NSCLC patients and 500 healthy controls were recruited and matched according to age and gender. The SNPs distributed in uPA and uPAR gene were selected for genotyping. The association between genotype and NSCLC risk was evaluated by computing the OR and 95% CI with multivariate unconditional logistic regression analyses. Results: Patients with the uPAR rs344781 T allele had a reduced risk of developing SCC patients (OR = 0.742; 95% CI = 0.579-0.950; P = 0.0176), especially a risk of developing male SCC patients (OR = 0.722; 95% CI = 0.546-0.954; P = 0.0219). And the uPAR rs344781 C/C allele homozygote was associated with an increased risk of SCC in patients (OR = 1.713; 95% CI = 1.145-2.563; P = 0.0083). However, neither allele frequencies nor genotype frequencies in uPA rs4065 were associated with NSCLC (P > 0.05). Conclusions: Our results revealed that genetic polymorphisms of uPAR rs344781 were associated with the risk of developing SCC (squamous cell carcinoma) in a Chinese population.

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Section: Discussioncontrasting

confidence: 99%

Association Between the Urokinase Plasminogen Activation System Polymorphisms and NSCLC in Chinese Population

Zhang¹,

Gu²,

Shen³

2016

IJCO

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“…Three polymorphic sites have been commonly reported; a T/C substitution in exon 6, a C/T change in intron 7 (14) and a T/C polymorphism at the +4065 nucleotide in the 3'-untranslated region (3'-UTR). Of the three sites, the 3'-UTR T/C polymorphic site is the most widely studied, and its relationship to complex diseases, such as non-small cell lung, prostate and bladder cancer, has been examined (15)(16)(17). Tsai et al (18) reported that the 'T' allele in 3'-UTR increased the risk of calcium stone disease.…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of the urokinase gene 3′-UTR T/C polymorphism and susceptibility to urolithiasis

Liu

Ren

et al. 2013

Biomedical Reports

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Abstract. Urokinase is involved in the processes of initiating urinary stones. Several published case-control studies have examined the relationship of urokinase gene 3'-untranslated region (3'-UTR) T/C polymorphism and urolithiasis, but yielded inconsistent findings. In this study, a comprehensive meta-analysis was conducted by pooling relevant studies to obtain reliable conclusions. Studies focusing on the association between urokinase gene 3'-UTR T/C polymorphism and urolithiasis were retrieved through PubMed, Medline, Web of Science and the China National Knowledge Infrastructure platform without any limit on language, until October 2012. Four independent articles were eventually identified as eligible for the final meta-analysis, involving 1,195 subjects. Crude odds ratios (ORs), as well as 95% confidence intervals (CIs), were assessed for the association by either fixed-or random-effects models using RevMan 5.0 software. Significant associations were noted in the 'TC vs. CC' codominant model for total population (OR=2.53; 95% CI, 1.43-4.46; P=0.001), Asian population (OR=2.46; 95% CI, 1.38-4.40; P=0.002), male (OR=2.98; 95% CI, 1.43-6.21; P=0.004), Hardy-Weinberg equilibrium (HWE) (OR=2.46; 95% CI, 1.38-4.40; P=0.002) and recurrence (OR=2.66; 95% CI, 1.51-4.67; P=0.00). Statistically significant associations were also observed in the 'TT+TC vs. CC' dominant model for the Asian, male, HWE and recurrence population (P<0.05). Additionally, a significant difference was detected in the 'T vs. C' allele model for HWE. However, there were no associations in either the 'TT vs. CC' codominant model or 'TT vs. TC+CC' recessive model. In conclusion, the present meta-analysis suggests that urokinase gene T allele may increase the susceptibility of urolithiasis.

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“…Through reviewing the abstracts and full texts, 20 case–control studies from 13 articles met our inclusion criteria. 14 , 17 – 20 , 28 – 35 A total of 7,037 cancer cases and 10,094 controls were included in the 20 case–control studies. The characteristics of these studies are listed in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The effects of genetic variations of the uPA system in cancer development have been recognized in recent years; however, the results are contradictory. 14 , 17 – 20 In the present study, we provided a comprehensive meta-analysis to evaluate the association of the uPA system polymorphisms and cancer risk. To the best of our knowledge, this is the first systematic meta-analysis addressing the association between the uPA system polymorphisms (not the PAI-1) and cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Association between the polymorphisms of urokinase plasminogen activation system and cancer risk: a meta-analysis

Meng

Lin

Ling

et al. 2015

OTT

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PurposeThe present study aimed to investigate the potential association between the urokinase plasminogen activation (uPA) system polymorphisms (rs4065, rs2227564, and rs344781) and cancer risk.MethodsAn extensive search was performed to identify published case–control studies on the association between the uPA system polymorphisms and cancer risk. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the relationship between the uPA system polymorphisms and cancer risk.ResultsA total of 20 studies comprising 7,037 cancer cases and 10,094 controls were identified and included in the present meta-analysis. Overall, significantly increased cancer risk was associated with the uPA polymorphism rs4065 (T vs C: OR 1.50, 95% CI: 1.19–1.89; TT vs CC: OR 4.63, 95% CI: 3.10–6.91; dominant model: OR 1.93, 95% CI: 1.60–2.33; recessive model: OR 3.02, 95% CI: 1.26–7.25) and the uPA receptor polymorphism rs344781 (T vs C: OR 1.13, 95% CI: 1.04–1.23; TC vs CC: OR 1.26, 95% CI: 1.06–1.49; TT vs CC: OR 1.35, 95% CI: 1.13–1.63; dominant model: OR 1.29, 95% CI: 1.10–1.52). No significant association was found between the uPA polymorphism rs2227564 and cancer risk. Subgroup analysis suggests that the T allele of the rs4065 (T allele vs C allele: OR 1.50, 95% CI: 1.19–1.89) and rs344781 polymorphisms (T allele vs C allele: OR 1.13, 95% CI: 1.04–1.23) was associated with increased cancer risk in Asians.ConclusionOur results suggest that the uPA polymorphism rs4065 and the uPA receptor polymorphism rs344781 are associated with increased cancer risk.

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Association of polymorphisms in the genes of the urokinase plasminogen activation system with susceptibility to and severity of non-small cell lung cancer

Cited by 12 publications

References 45 publications

Association Between the Urokinase Plasminogen Activation System Polymorphisms and NSCLC in Chinese Population

Association Between the Urokinase Plasminogen Activation System Polymorphisms and NSCLC in Chinese Population

Meta-analysis of the urokinase gene 3′-UTR T/C polymorphism and susceptibility to urolithiasis

Association between the polymorphisms of urokinase plasminogen activation system and cancer risk: a meta-analysis

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