Association Between the Urokinase Plasminogen Activation System Polymorphisms and NSCLC in Chinese Population

Abstract

Aim: To evaluate the influence of uPA and uPAR gene polymorphisms in the susceptibility to NSCLC. Methods: A total of 500 NSCLC patients and 500 healthy controls were recruited and matched according to age and gender. The SNPs distributed in uPA and uPAR gene were selected for genotyping. The association between genotype and NSCLC risk was evaluated by computing the OR and 95% CI with multivariate unconditional logistic regression analyses. Results: Patients with the uPAR rs344781 T allele had a reduced risk of developing SCC patients (OR = 0.742; 95% CI = 0.579-0.950; P = 0.0176), especially a risk of developing male SCC patients (OR = 0.722; 95% CI = 0.546-0.954; P = 0.0219). And the uPAR rs344781 C/C allele homozygote was associated with an increased risk of SCC in patients (OR = 1.713; 95% CI = 1.145-2.563; P = 0.0083). However, neither allele frequencies nor genotype frequencies in uPA rs4065 were associated with NSCLC (P > 0.05). Conclusions: Our results revealed that genetic polymorphisms of uPAR rs344781 were associated with the risk of developing SCC (squamous cell carcinoma) in a Chinese population.