Association of Polymorphisms in the Human Interferon -?? And Interleukin-10 Gene With Acute and Chronic Kidney Transplant Outcome

Abstract

In this study we have shown that high producer genotype for IFN-gamma may have an influence on acute rejection of kidney transplants, particularly in patients on cyclosporine monotherapy. It is also associated with worse long-term graft function. On the contrary high IL-10 production may have a long-term protective effect.

Immunosurveillance of childhood ALL: polymorphic interferon-γ alleles are associated with age at diagnosis and clinical risk groups

“…However, strict adoptions of Bonferroni corrections would imply only a loss of statistical significance. Overall, we think that the published biological and clinical [8][9][10][11][12][13][14][15][16][17] relevance of the investigated polymorphism, the mechanistic model for different expression levels of IFN-g, 7 and the well-established concept of an IFN-g-dependent immunosurveillance in mice [1][2][3][4][5] support that the observed relationship between the investigated polymorphism and the associated variables in our study is real.…”

“…In various immune-mediated diseases, such as autoimmune diseases, [8][9][10][11][12] graft-versus-host-disease 13,14 and fibrosis in lungtransplant recipients, 15 the onset and severity of the clinical phenotype have been associated with the presence of the 12 CA-repeat polymorphism. Furthermore, the IFN-g polymorphism contributes substantially to the development of tuberculosis 16 and leprosy, 17 providing clues for the role of IFN-g in immunopathophysiological mechanisms.…”

Ethnicity Greatly Influences Cytokine Gene Polymorphism Distribution

“…Kidney transplant recipients possessing genotypes that predict high IL-10 expression experience increased rejection events, and those whose genotypes predict both high TNF-a and high IL-10 expressions are at elevated risk for acute vascular rejection (2). Asderakis et al observed an association between renal allograft rejection and individuals that were high producers of both IL-10 and IFN-g (9). Compared with Whites, Asian populations tend to be low producers of IL-10.…”

“…For instance, recipients of human leukocyte antigen (HLA)-DR mismatched renal allografts whose genotypes predicted high TNF-a and IL-10 production were more likely to undergo an acute rejection episode than individuals with genotypes predicting low TNFa and IL-10 production (2). Furthermore, high IFN-g production has been correlated with a greater incidence of acute and chronic rejection (9). Others have demonstrated the relationship of cytokine gene polymorphisms to acute or chronic rejection following heart (10-12), liver (13,14) or lung (8) transplantation.…”

Simultaneous analysis of interleukin-10 gene microsatellites and single-nucleotide polymorphisms in parallel with tumour necrosis factor and interferon-gamma short tandem repeats by fluorescence-based polymerase chain reaction

“…Allele 3 is the most commonly observed in our German-Caucasian group and the genotype distribution exhibits a preponderance of heterozygotes and homozygotes containing this allele 3, which corresponds to 12 CA repeats as described by Pravica et al 40 where this allele was called 'allele 2'. 63 In the analysed African population, however, the allele 4 was dominant. In Table 6, the allele frequencies of three different geographic groups are shown.…”