Association of Polymorphism +874 T/A Interferon Gamma Gene with Susceptibility to Pulmonary Tuberculosis in Medan, Indonesia

Abstract

BACKGROUND: Pulmonary tuberculosis (TB) is still a disease that concerns in the world due to its high incidence, especially in developing countries, including Indonesia. Polymorphism +874 T/A interferon-gamma (IFN-γ) is one of the host genetic factors that have been widely studied and has been shown to be associated with susceptibility to pulmonary TB. AIM: This study aims to determine the association polymorphism +874 T/A IFN-γ gene with susceptibility to pulmonary TB in Medan population. METHODS: A total of 82 pulmonary TB patients and 85 healthy controls were examined in this case–control study. SPSS 25 is used to process and analyze all data where the Pearson Chi-square is used to analyze the association between genotype and susceptibility to pulmonary TB. RESULTS: The polymorphism +874 T/A IFN-γ gene was not significantly associated with susceptibility to pulmonary TB in patients compared to controls (p = 0.395) and there was no association between allele frequency and susceptibility to pulmonary TB (p = 0.158). CONCLUSION: Our study suggests no association of polymorphism +874 T/A IFN-γ gene with pulmonary TB in Medan, Sumatera Utara, Indonesia.