Association of plasma β-amyloid with MRI markers of structural brain aging the 3-City Dijon study

Association Between Periodontitis and Amyloid β Peptide in Elderly People With and Without Cognitive Impairment

“…Another finding of interest was that serum Aβ 1‐42 and Aβ 1‐40 peptide concentrations were associated with cognitive impairment and that these associations were in turn modulated by the presence of severe periodontal disease. Most studies have reported that presence of Aβ peptide in blood has no diagnostic utility per se and therefore does not explain accumulation of Aβ in the brain, 34 whereas others have related its presence to increased risk of dementia‐associated brain changes 35 . No linear relationship was found between Aβ 1‐42 or Aβ 1‐40 concentrations and dementia severity in the present study, given the decreased concentrations in patients versus control participants in the most severe cases (data not shown), as previously reported 36 .…”

Plasma biomarkers are associated with agitation and regional brain atrophy in Alzheimer’s disease

“…In dementia-free subjects, a high plasma Aß1-40 level and low plasma ratio of Aß1-42/Aß1-40 were associated with smaller hippocampal volume and accelerated global and regional brain atrophy, respectively 20 . Sotolongo-Grau et al .…”

“…Increased and decreased plasma amyloid ß peptide 1–40 (Aß1-40) and amyloid ß peptide 1–42 (Aß1-42) levels have been reported in patients with AD 17–19 . Increased plasma Aß1-40 levels have been associated with atrophy of the medial temporal lobe structures in subjects without dementia 20 . Plasma amyloid levels have also been correlated with cognitive dysfunction in patients with AD 21 .…”

Plasmalemmal VDAC-1 corroborated as amyloid Aß-receptor

“…However, my hope is that looking on Alzheimer pathogenesis in the context of induced cell death will stimulate the field, this the more as recent literature indicates that amyloid Aß may work this way in other places (Martí-Fàbregas et al, 2014 ; Kaffashian et al, 2015 ; Zetterberg, 2015 ).…”