Association Between Periodontitis and Amyloid β Peptide in Elderly People With and Without Cognitive Impairment

Gil-Montoya, José Antonio; Barrios, Rocío; Santana, Soraya; Sánchez-Lara, Inés; Carnero-Pardo, C.; Fornieles-Rubio, Francisco; Montés, Juan Francisco Jordán; Ramírez, Cinthya Judith López; González‐Moles, Miguel Ángel

doi:10.1902/jop.2017.170071

Cited by 33 publications

(37 citation statements)

References 39 publications

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“…In general, inflammation is considered to play a key role in the physiopathology of dementia, with peripheral inflammation as one possible cause among others. Our group recently observed that the production of β‐amyloid protein is higher in patients with severe periodontal disease, demonstrating the role of periodontitis as an effect‐modifying variable …”

Section: Introductionmentioning

confidence: 92%

“…Details of the oral examination were previously published. 14,21 In brief, four trained and calibrated dentists conducted an in-depth oral examination on the same day as the psycho-neurological examination, recording the number of teeth present and determining the Löe and Silness plaque index, clinical attachment loss index (CALindex), probing depth and Ainamo & Bay Bleeding Index at a minimum of three sites in at least two teeth per sextant or in all teeth when <12 were present. A questionnaire was completed on sociodemographic and medical-pharmacological data, alcohol and tobacco consumption, presence/absence of dental prosthesis, oral hygiene habits and dental visits.…”

Section: Oral Examinationmentioning

confidence: 99%

“…Our group recently observed that the production of β-amyloid protein is higher in patients with severe periodontal disease, demonstrating the role of periodontitis as an effect-modifying variable. 21 However, the role of peripheral inflammation of periodontal origin has yet to be fully elucidated. 11 Few studies have analysed in depth the involvement in dementia of systemic inflammation and its biomarkers due to periodontal disease, [22][23][24] all based on a limited number of cytokines and partially confirming the role of systemic inflammation of periodontal origin in dementia.…”

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Systemic inflammatory impact of periodontitis on cognitive impairment

et al. 2019

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Objectives The role in dementia of systemic inflammation derived from periodontal disease is not fully elucidated. The objective of our study was to examine the impact of inflammation on the relationship between periodontitis and cognitive impairment. Methods We have designed a case (n = 171) and control (n = 131) study to determine the periodontal health status, grade of cognitive impairment/dementia and systemic inflammation level, the last being measured by analysis of 29 inflammatory biomarkers using multiplex techniques. Results At the time of sampling, 11 of the 29 inflammatory biomarkers were associated with cognitive impairment in patients with more severe periodontitis. However, the inflammatory response to severe periodontitis was more reduced (lower biomarker concentrations) in cases (with cognitive impairment or dementia) than in (cognitively healthy) controls, an unexpected finding. Conclusions Based on these results, we cannot confirm that systemic inflammation derived from periodontal disease plays a relevant role in the aetiology of cognitive impairment.

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confidence: 92%

Section: Oral Examinationmentioning

confidence: 99%

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Systemic inflammatory impact of periodontitis on cognitive impairment

et al. 2019

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“…Higher brain amyloid load has been reported as a central feature of Alzheimer′s disease and clinical attachment loss (CAL) ≥3 mm has been associated with higher brain amyloid‐β (Aβ) load among elderly individuals (Kamer et al., ). In a recent case–control study, higher plasma Aβ 1‐42 peptide concentrations were reported in individuals with severe periodontal disease compared to individuals with healthy periodontal status (Gil‐Montoya, Barrios et al., ). Additionally, lipopolysaccharides from periodontal pathogens have been identified in the brain tissues of patients with Alzheimer′s disease in post‐mortem analysis (Poole, Singhrao, Kesavalu, Curtis, & Crean, ) and serum IgG levels to periodontal microbiota has been associated to risk for incident Alzheimer′s disease (Noble et al., ).…”

Section: Introductionmentioning

confidence: 98%

Longitudinal evaluation of periodontitis and development of cognitive decline among older adults

Nilsson

Berglund

Renvert

2018

J Clinic Periodontology

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“…Recently, it has been postulated that periodontitis could be involved in the synthesis and accumulation of Aβ in the brain . Moreover, levels of APP are increased in gingival tissues with periodontitis and severe periodontal patients with cognitive decline showed higher levels of Aβ 1‐40 compared with those without periodontitis …”

Section: Introductionmentioning

confidence: 99%

Periodontitis is associated with systemic inflammation and vascular endothelial dysfunction in patients with lacunar infarct

Leira

Rodríguez‐Yáñez

Arias

et al. 2018

Journal of Periodontology

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Background Periodontitis has been associated with lacunar infarct (LI), a type of cerebral small vessel disease. The objective of this study was to ascertain whether periodontitis is associated with increased circulating levels of systemic inflammation and endothelial dysfunction biomarkers in patients with LI. Methods One hundred twenty patients with LI and 120 healthy controls underwent a full‐mouth periodontal examination. The periodontal inflamed surface area (PISA) was calculated for each participant. Demographic, medical, and neurological information were recorded from all of them. In addition, blood samples were collected in order to investigate differences in terms of interleukin (IL)‐6, IL‐10, pentraxin (PTX) 3, soluble fragment of tumor necrosis factor‐like weak inducer of apoptosis (sTWEAK) and amyloid‐beta (Aβ) peptides (i.e., Aβ1‐40, and Aβ1‐42) measured in serum. Results Periodontitis was independently associated with increased levels of IL‐6 (R2 = 0.656, P < 0.001), PTX3 (R2 = 0.115, P < 0.001), sTWEAK (R2 = 0.527, P < 0.001), and Aβ1‐40 (R2 = 0.467, P < 0.001) in patients with LI. Within patients with poor outcome, PISA positively correlated with IL‐6 (r = 0.738, P < 0.001), PTX3 (r = 0.468, P = 0.008), sTWEAK (r = 0.771, P < 0.001), and Aβ1‐40 (r = 0.745, P < 0.001). Conclusions Our data suggest a link between periodontitis, systemic inflammatory response, and disruption of the vascular endothelial function in patients with LI. Experimental studies are needed to elucidate possible pathways through which periodontitis could lead to this systemic inflammatory state with impairment of the endothelial function in LI. Further longitudinal studies with large samples are warranted to confirm our findings.

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Association Between Periodontitis and Amyloid β Peptide in Elderly People With and Without Cognitive Impairment

Abstract: Plasma Aβ levels are higher in individuals who have severe periodontal disease. The presence of periodontitis may modify the association between Aβ and cognitive impairment.

Cited by 33 publications

References 39 publications

Systemic inflammatory impact of periodontitis on cognitive impairment

Systemic inflammatory impact of periodontitis on cognitive impairment

Longitudinal evaluation of periodontitis and development of cognitive decline among older adults

Periodontitis is associated with systemic inflammation and vascular endothelial dysfunction in patients with lacunar infarct

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