Association of Plasma Total Cysteine and Anthropometric Status in 6–30 Months Old Indian Children

Schwinger, Catherine; Chowdhury, Ranadip; Sharma, Shivani; Bhandari, Nita; Taneja, Sunita; Ueland, Per Magne; Strand, Tor A.

doi:10.3390/nu12103146

Cited by 3 publications

(1 citation statement)

References 54 publications

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“…A similar study design could be used for active growth life-stages, as was shown recently in 6-12 months stunted Malawian children, that although growth was associated with several serum IAA concentrations, length velocity Z scores were more associated with dispensable amino acids, especially glycine, serine and proline [22]. Similarly in 6-30 months Indian children living in low-middle socioeconomic areas poor growth was associated with low cysteine plasma concentrations [23]. Recently in growing pigs it was shown that supplementing serine and glycine to a low protein diet promoted growth and skin collagen [24 & ] that provides further evidence that indeed, a dietary need could be established with an ideal study design.…”

Section: Serine Glycine and Cysteinementioning

confidence: 82%

A discussion on the ‘dispensable’ amino acids

Ennis

Elango

2021

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review Recently, the concept of dietary dispensable amino acids has been increasingly challenged, as more indirect and direct (experimental) evidence has pointed to the need for them in the diet during specific life stages or disease states. Here, we discuss the classification of amino acids, methods to assess the needs for dispensable amino acids with experimental evidence from our recent studies, and highlight the role of specific dispensable amino acids in metabolism and health. Recent findings There exist differences among the dispensable amino acids to act as effective nitrogen sources in humans. Glycine, a dispensable amino acid is conditionally indispensable in later stages of human pregnancy. Summary The so-called ‘dispensable’ amino acids are quantitatively nearly 75% of the daily protein needs in humans. In certain life-stages and diseases, there is a dietary demand for the dispensable amino acids. Future well-designed studies are required to identify the dietary demand for these amino acids, which will certainly be useful for dietary management in specific diseases and to maintain health across all life-stages.

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Section: Serine Glycine and Cysteinementioning

confidence: 82%

A discussion on the ‘dispensable’ amino acids

Ennis

Elango

2021

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Assessment of the Concentrations of Selected Aminothiols in Patients after COVID-19

Szołtysek-Bołdys,

Zielińska-Danch,

Łoboda

et al. 2024

JCM

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Background: Data show that due to endothelial damage and thrombogenic effects, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection may accelerate the development of atherosclerosis and increase the risk of cardiovascular diseases (CVDs). The impaired metabolism of aminothiols increases oxidative stress, as these molecules are involved in antioxidant defense as well as in thiol redox control. In this study, total levels of selected aminothiols (i.e., cysteine (Cys), homocysteine (HCy), and glutathione) in convalescents after coronavirus disease of 2019 (COVID-19) were evaluated. The analyses were made according to the sex of the patients, time from COVID-19 onset, and COVID-19 severity. Methods: The study group consisted of 212 patients after COVID-19. Levels of total aminothiols were assessed in the blood plasma using high-performance liquid chromatography (HPLC). Results: The mean Cys concentrations were higher in men than in women (229.92 µmol/L ± 51.54 vs. 210.35 µmol/L ± 41.90, respectively; p = 0.003). Differences in Cys levels were also noticed in the total study group between patients distinguished due to time from disease onset (226.82 µmol/L ± 40.57 in <12 weeks, 232.23 µmol/L ± 47.99 in patients 12–24 weeks, and 208.08 µmol/L ± 48.43 in patients >24 weeks; p = 0.005). In addition, over 11% of total patients 12–24 weeks from disease onset had Cys levels above 300 µmol/L compared to almost 4% of patients <12 weeks and 2% of patients >24 weeks (p = 0.046). In sex-adjusted subgroups, significant differences due to time from COVID-19 were found in Cys levels in women (p = 0.004) and in glutathione levels in men (p = 0.024). None of the aminothiol levels differed between the subgroups based on the severity of COVID-19. Conclusions: Men had overall higher Cys levels than women. Cys levels were lower >24 weeks after COVID-19 onset than in the earlier period after disease onset. A partial elevation in Cys levels 12–24 weeks after the disease onset may contribute to the increase in CVD risk in the post-COVID-19 period.

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Association of Maternal Plasma Total Cysteine and Growth among Infants in Nepal: A Cohort Study

et al. 2020

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Cysteine is a semi-essential amino acid that has been positively associated with growth in children. However, transgenerational effects remain unclear. The aim of this analysis was to assess whether maternal plasma total cysteine (tCys) concentration is associated with various growth indicators in infants living in peri-urban settings in Bhaktapur, Nepal. We used data from the 561 mothers enrolled in an ongoing randomized controlled trial. We built linear regression models to evaluate the associations between maternal tCys and birth weight, length-for-age Z-scores (LAZ) and weight-for-length Z-scores (WLZ) at birth and six months of age. Maternal tCys was inversely associated with birth weight among boys after adjusting for confounders (p < 0.05). In addition, there was a negative association between maternal tCys and LAZ at birth (p < 0.01). No associations between maternal tCys and the other anthropometric indicators were found significant, although there was a tendency for maternal tCys to be associated positively with WLZ at birth among girls (p < 0.10). This is a first study evaluating transgenerational relation of tCys on growth in infants. Further, larger and more comprehensive studies are needed to determine if and how maternal tCys alters child growth.

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Association of Plasma Total Cysteine and Anthropometric Status in 6–30 Months Old Indian Children

Cited by 3 publications

References 54 publications

A discussion on the ‘dispensable’ amino acids

A discussion on the ‘dispensable’ amino acids

Assessment of the Concentrations of Selected Aminothiols in Patients after COVID-19

Association of Maternal Plasma Total Cysteine and Growth among Infants in Nepal: A Cohort Study

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