Association of Plasma Leptin, Homocysteine and Nitric Oxide Levels With the Presence and Unstability of Coronary Artery Disease

Basati, Gholam; Razavi, Àmirnader Emami; Abdi, Soheila; Sarrafzedegan, Nizal

doi:10.2217/bmm.13.131

Cited by 15 publications

(16 citation statements)

References 44 publications

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“…Most adipokines not only play a significant role in metabolic diseases [ 5 ], but also exert multiple effects on the function of vessels and heart [ 6 ]. Adipokines can accelerate atherosclerosis [ 7–9 ] and contribute to the incidence of acute coronary syndrome [ 10 , 11 ]. In recent years, novel adipokines are emerging and their roles in cardiovascular diseases are being investigated.…”

Section: Introductionmentioning

confidence: 99%

Circulating level of fibroblast growth factor 21 is independently associated with the risks of unstable angina pectoris

Cheng

Qiao

et al. 2018

Bioscience Reports

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There is increasing evidence that serum adipokine levels are associated with higher risks of cardiovascular diseases. As an important adipokine, fibroblast growth factor 21 (FGF21) has been demonstrated to be associated with atherosclerosis and coronary artery disease (CAD). However, circulating level of FGF21 in patients with angina pectoris has not yet been investigated. Circulating FGF21 level was examined in 197 patients with stable angina pectoris (SAP, n=66), unstable angina pectoris (UAP, n=76), and control subjects (n=55) along with clinical variables of cardiovascular risk factors. Serum FGF21 concentrations on admission were significantly increased more in patients with UAP than those with SAP (Ln-FGF21: 5.26 ± 0.87 compared with 4.85 ± 0.77, P<0.05) and control subjects (natural logarithm (Ln)-FGF21: 5.26 ± 0.87 compared with 4.54 ± 0.72, P<0.01). The correlation analysis revealed that serum FGF21 concentration was positively correlated with the levels of cardiac troponin I (cTnI) (r2 = 0.026, P=0.027) and creatine kinase-MB (CK-MB) (r2 = 0.023, P= 0.04). Furthermore, FGF21 level was identified as an independent factor associated with the risks of UAP (odds ratio (OR): 2.781; 95% CI: 1.476–5.239; P=0.002), after adjusting for gender, age, and body mass index (BMI). However, there were no correlations between serum FGF21 levels and the presence of SAP (OR: 1.248; 95% CI: 0.703–2.215; P=0.448). The present study indicates that FGF21 has a strong correlation and precise predictability for increased risks of UAP, that is independent of traditional risk factors of angina pectoris.

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Section: Introductionmentioning

confidence: 99%

Circulating level of fibroblast growth factor 21 is independently associated with the risks of unstable angina pectoris

Cheng

Qiao

et al. 2018

Bioscience Reports

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“…Basati et al 21 reported that low leptin levels are correlated with higher cardiovascular events and mortality in patients with stable coronary artery disease. Furthermore, some cardio protective effects of leptin have been reported in experimental settings.…”

Section: Introductionmentioning

confidence: 99%

Adiponectin, leptin, nitric oxide, and C-reactive protein levels in kidney transplant recipients: comparison with the hemodialysis and chronic renal failure

2016

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Background: Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in patients with chronic kidney disease (CKD) including kidney transplant recipients (KTR). Secondary lipid metabolism disorders, endothelial dysfunction, and inflammation enhance the risk of CVD development in these patients. The aim of the present study was to investigate the lipid profile, adiponectin, leptin, nitric oxide (NO), and high sensitivity C-reactive protein (hs-CRP) levels in KTR and to compare these parameters with those of the patients with chronic renal failure (CRF), hemodialysis (HD) patients, and healthy controls. Methods: Serum adiponectin and leptin levels were measured by radioimmunoassay; hs-CRP was determined immunoturbidimetrically. Determination of NO was based on the Griess reaction. Results: Compared with the control group, serum NO and adiponectin levels were significantly higher in the KTR, CRF, and HD groups; hs-CRP levels were significantly higher in the KTR and HD groups; leptin levels were significantly higher in the KTR. In addition, serum NO level was significantly higher in the KTR compared to CRF cases. Adiponectin correlated positively with high density lipoprotein-cholesterol in the control and patient groups. A positive correlation was observed between hs-CRP and NO in the KTR and the patients with CRF. Serum adiponectin levels were inversely correlated with hs-CRP and leptin in the HD group. Conclusion: KTR suffer from inflammation and accompanying changes in levels of adipocytokines and NO which contribute to the increased risk of CVD in these patients.

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“…Korelacija je bila značajno negativna prema trigliceridima, indeksu telesne mase BMI, jutarnjoj hiperglikemiji, po kriterijumima American Diabetes Association Criteria. [16,17].…”

Section: Diskusijaunclassified

Comparative analysis of biochemical parameters of atherosclerosis adiponectin and resistin in patients with diabetes mellitus and coronary heart disease

Rašić¹,

Perić²,

Rašić³

et al. 2015

Praxis Med

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Najznačajniji adipocitokini koji utiču na stvaranje i regresiju ateromskih plakova u koronarnim krvnim sudovima su adiponektin i rezistin. Suština ovog ispitivanja je da se utvrdi korelacija vodećih biohemijskih parametara ateroskleroze, adiponektina i rezistina i utvrdi njihova međuzavisnost sa ostalim biohemijskim parametrima u bolesnika sa dijabetes melitusom i koronarnom bolešću srca. U našem radu je bilo obuhvaćeno 140 ispitanika i to 40 kontrolna grupa (zdravi), 50 sa dijabetes melitusom i 50 sa koronarnom bolešću srca (infarct miokarda i angina pectoris). Dobili smo da je prosečna vrednost adiponektina u grupi sa dijabetes melitusom tip 2 značajno manja u odnosu na kontrolnu grupu (4.38 prema 6.74, p=0.001, p<0.05). U istoj ispitivanoj grupi prosečna vrednost rezistina je značajno veća u odnosu na kontrolnu grupu (15.8 prema 7.88, p<0.001). Prosečna vrednost adiponektina i rezistina kod ispitanika sa infarktom miokarda i anginom pektoris se ne razlikuju od vrednosti dobijene kod dijabetes melitusa (4.94 prema 4.38, p=0.397 p>0.05). U istoj ispitivanoj grupi prosečna vrednost rezistina je značajno veća u odnosu na kontrolnu grupu (15.73 prema 7.88, p=0.001 p<0.01) i ne razlikuje se u odnosu na grupu sa dijabetes melitusom. Vrednosti Pearsonovg koeficijenta korelacije prikazuje da je najveća obrnuto proporcionalna zavisnost pada adiponektina uz istovremeni porast rezistina izražena kod pacijenata sa infarktom miokarda, što je izraženo vrlo dobrim koeficijentom korelacije (-0.36). U svim ispitivanim grupama se pokazuje da postoji negativna korelativna veza između rezistina i adiponektina, odnosno sa porastom rezistina vrednosti adiponektina se smanjuju.Ključne reči: adipocitokini, diabetes mellitus, koronarna bolest. UVODAdipocitokini adiponektin i rezistin predstavljaju veoma bitne sekretorne hormone masnog tkiva. Učest-vuju u procesu ateroskleroze tako što adiponektin ispoljava svoje protektivno delovanje a rezistin direktno utiče na stvaranje ateromskih plakova. I jedan i drugi metabolit predstavljaju sastavni deo jednog šireg sistema negativnog delovanja na ateroskrerozu krvnih sudova a koji se zajedničkim imenom zove metabolički sindrom. Faktori rizika koronarne bolesti predstavljaju veoma bitno polazište u razumevanju etiologije i patogeneze ateroskleroze koronarnih krvnih sudova a samim tim i pojedinih kliničkih oblika koronarne bolesti srca. Prospektivna Framinghamska studija (The Framingham Heart Study) obezbedila je jaku potporu konceptu u kome hiperholesterolemija, hipertenzija i drugi faktori rizika koreliraju sa kardiovaskularnim rizikom [1]. Slične observacione studije nezavisno rađene u SAD i drugim zemljama podržale su koncept "faktora rizika" za kardiovaskularne bolesti. Brojne populacione studije uključujući i studiju sedam zemalja (Seven countru stady) koju je vodio Keys sa saradnicima, ukazale su na vezu između načina ishrane i kardiovskularnog rizika. Praktično gledano faktore rizika delimo na one na koje možemo delovati (promenjivi faktori rizika), a to su pušenje, gojaznost, fizička ne...

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Association of Plasma Leptin, Homocysteine and Nitric Oxide Levels With the Presence and Unstability of Coronary Artery Disease

Abstract: Some athrogenic effects of leptin may be mediated by affecting tHcy and NO levels. Plasma leptin, tHcy and NO levels showed significant contribution to CAD prediction and discrimination.

Cited by 15 publications

References 44 publications

Circulating level of fibroblast growth factor 21 is independently associated with the risks of unstable angina pectoris

Circulating level of fibroblast growth factor 21 is independently associated with the risks of unstable angina pectoris

Adiponectin, leptin, nitric oxide, and C-reactive protein levels in kidney transplant recipients: comparison with the hemodialysis and chronic renal failure

Comparative analysis of biochemical parameters of atherosclerosis adiponectin and resistin in patients with diabetes mellitus and coronary heart disease

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