Association of Plasma Homocysteine and Macular Edema in Type 2 Diabetes Mellitus

Aydın, Erdinç; Demir, Helin Deniz; Özyurt, Hüseyın; Etikán, Ílker

doi:10.1177/112067210801800210

Cited by 26 publications

(25 citation statements)

References 35 publications

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“…13,14 In a controlled clinical trial of metformin, a decrease to subnormal levels of previously normal serum vitamin B12 levels occurred possibly due to interference with B12 absorption from the B12-intrinsic factor complex. 19 Nevertheless, metformin did not show its significant effect on serum B12 of the patients with or without diabetic macular edema from our observation.…”

Section: Discussionmentioning

confidence: 98%

“…13,14 We enrolled two groups of diabetic subjects with macular edema and without into our observation. The two groups had no severe NPDR and PDR, but had comparable either mild NPDR or moderate NPDR.…”

Section: Discussionmentioning

confidence: 99%

“…7,11 Studies show that homocysteine concentrations are related to diabetic microvascular and macrovascular diseases. 12 However, limited studies are focused on homocysteine in association with diabetic macular edema, 13,14 the independent role of homocysteine in diabetic macular edema has not been well defined. For this reason, we included potential co-founders for meticulous analysis to evaluate the relationship between homocysteine concentration and diabetic macular edema among subjects with type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

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Homocysteine is Linked to Macular Edema in Type 2 Diabetes

Zhang

Shi

et al. 2014

Current Eye Research

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Homocysteine is Linked to Macular Edema in Type 2 Diabetes

Zhang

Shi

et al. 2014

Current Eye Research

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“…For example, Aydemir et al16 report an elevation of homocysteine in vitreous of diabetic patients and speculate that the homocysteine elevation is due to a breakdown of the blood retinal barrier 16. Aydin and co-workers examined the association of plasma homocysteine and macular edema in type 2 diabetes and suggested that hyperhomocysteinemia may play a role in vascular dysregulation and endothelial dysfunction in patients with diabetic retinopathy, particularly in development of macular edema 31. In a separate clinical study Brazionis and colleagues suggest that plasma total homocysteine concentration may be a useful biomarker and/or a novel factor for increased risk of diabetic retinopathy in people with type 2 diabetes 32.…”

Section: Discussionmentioning

confidence: 99%

Diabetes Accelerates Retinal neuronal cell Death in A Mouse Model of endogenous Hyperhomocysteinemia

et al. 2009

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Hyperhomocysteinemia has been implicated in visual dysfunction. We reported recently that mice with endogenous hyperhomocysteinemia, due to mutation of the cystathionine-β-synthase (cbs) gene, demonstrate loss of neurons in the retinal ganglion cell (RGC) layer and other retinal layers as homocysteine levels increase. Some clinical studies implicate hyperhomocysteinemia in the pathogenesis of diabetic retinopathy, which is also characterized by RGC loss. The present study used cbs +/-mice to determine whether modest elevation of plasma homocysteine, in the presence of diabetes, accelerates neuronal cell loss. Diabetes (DB) was induced in 3 wk old cbs +/-and wildtype mice using streptozotocin; four groups of mice were studied: DB cbs +/-; non-DB cbs +/-; DB cbs +/+ ; non-DB cbs +/+ . One group of diabetic cbs +/-mice was maintained on a high methionine diet (HMD, 0.5% methionine drinking water) to increase plasma homocysteine slightly. Eyes were harvested at 5, 10 and 15 weeks post-onset of diabetes; retinal cryosections were examined by light microscopy and subjected to systematic morphometric analysis. Diabetic cbs +/-had significantly fewer RGCs at 5 weeks compared to age-matched, non-diabetic cbs +/-and wildtype controls (10.0 ± 0.5 versus 14.9 ± 0.5 and 15.8 ± 0.6 cells/100 µm retina length, respectively). Significant differences in retinas of DB/high homocysteine versus controls were obtained 15 wks postonset of diabetes including fewer RGCS and decreased thickness of inner nuclear and plexiform layers. Moderate increases in plasma homocysteine coupled with diabetes cause a more dramatic alteration of retinal phenotype than elevated homocysteine or diabetes alone and suggest that diabetes accelerates the retinal neuronal death in hyperhomocysteinemic mice.

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“…Many studies since have confirmed this association for type 2 diabetes mellitus as well. [57][58][59] It is also true that severity of retinopathy correlates strongly with Hcy level, independent of glycaemic control. 60 Higher Hcy levels are observed in individuals with proliferative retinopathy compared to non-proliferative retinopathy, even though in both instances the levels are significantly elevated compared to control.…”

Section: Diabetic Retinopathymentioning

confidence: 99%