Homocysteine in the Pathogenesis of Chronic Glaucoma

Kadhim, Mustafa R.; Clement, Colin I

doi:10.5772/18506

Cited by 3 publications

(5 citation statements)

References 90 publications

(78 reference statements)

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“…There are studies implying that genetic polymorphism, such as variant MTHFR A1298C, may increase the risk for developing glaucoma, especially in the heterozygote model [ 9 , 22 ]. However, in order to support this idea, extended studies are still necessary [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Polymorphism in the MTHFR gene may decrease the activity of methylenetetrahydrofolate reductase, leading to a mild increase of homocysteine in the blood [ 7 ]. This may cause problems within blood vessels and is considered a risk factor for thromboembolism.…”

Section: Genetic Features On Retinal Vein Occlusionmentioning

confidence: 99%

“…There are several studies that support that genetic polymorphism, such as the variant MTHFR A1298C, may increase the risk for developing glaucoma, especially in the heterozygote model [ 9 , 22 ]. However, while there are meta-analyses supporting this idea, other studies are yet to be extended, given the fact that, while some of these studies tried to maintain a heterogeneity of the assessed patients, other studies were made on specific ethnic groups [ 7 ].…”

Section: Considerations On Genetical Factors Linking Glaucoma Associa...mentioning

confidence: 99%

“…Since the 90’s, POAG has been especially linked to RVO. However, there is still a need to properly investigate the connection between different types of RVO and different types of glaucoma, considering all data available are either insufficient or misleading [ 7 ].…”

Section: Considerations On Genetical Factors Linking Glaucoma Associa...mentioning

confidence: 99%

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Highlights on Genetic Polymorphism Associated with Thromboembolic Risk; Implications in Ophthalmic and Autoimmune Disorders—A Review

et al. 2023

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The present paper explores genetic polymorphism and its association with thromboembolic retinal venous disorders, such as central/hemi-retinal vein occlusion, as well as possible correlations with other ocular findings, such as closed angle glaucoma, but also with autoimmune general disorders. In this review, we are highlighting the importance of establishing a correspondence between all of the above, since they all have complex etiopathogeneses; sometimes, when all coexist together, they could generate effects that may be very difficult to manage. There are studies supporting that genetic polymorphism, such as the variant MTHFR A1298C, may increase the risk for developing glaucoma, especially in the heterozygote model. Being aware of all these aspects may prove to be useful in patients with several associated diseases, as a combined effort between several medical specialties may prove to the benefit of these patients. Our review, completed with an exemplifying clinical case, shows that it is necessary to raise awareness of all aspects of a complex medical situation, including the genetic one, of a patient being at risk for thromboembolic episodes, for preventing them or managing them promptly and properly in the future.

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Section: Discussionmentioning

confidence: 99%

Section: Genetic Features On Retinal Vein Occlusionmentioning

confidence: 99%

Section: Considerations On Genetical Factors Linking Glaucoma Associa...mentioning

confidence: 99%

Section: Considerations On Genetical Factors Linking Glaucoma Associa...mentioning

confidence: 99%

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Highlights on Genetic Polymorphism Associated with Thromboembolic Risk; Implications in Ophthalmic and Autoimmune Disorders—A Review

et al. 2023

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“…10 Pada glaukoma bisa terjadi peningkatan kadar homosistein 11 dan perlu digunakan suplementasi vitamin B1 dan B12 dalam menurunkan kadar homosistein tersebut. 12 Beberapa penelitian lain menemukan bahwa antioksidan seperti vitamin B1 dan B12 memiliki khasiat yang sedikit bahkan tidak berkhasiat sama sekali sebagai terapi untuk penyakit glaukoma. 13 Vitamin B1, atau Tiamin dilaporkan tidak memiliki efek terapi pada IOP (intraocular pressure) yang merupakan faktor resiko utama glauakoma.…”

Section: Metode Penelitianunclassified

Pemberian Vitamin Pada Penyakit Mata

Jacobs¹,

Sumual²,

Rares³

2015

eCl

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Vitamin intervention is known as a part of efforts to prevent the organ damages due to ocular diseases. However, ocular side effects associated with vitamin therapy has been reported, frequently. This study aimed to discover vitamin therapy and its relevancy in ocular diseases. This was a retrospective descriptive study which was conducted at the Department of Ophthalmology, General Hospital of Prof. Dr. R. D. Kandou Manado from November – December 2014. Population consisted of 435 medical records from July – September 2014. History of vitamin therapy was observed in 5 samples. Glaucoma suspect with NutriVision™ (relevant/irrelevant), KSS (Kearns-Sayre syndrome) with vitamin B1 and B +C complex (relevant), PACG (primary angle closure glaucoma) + Keratopathy with vitamin B+C comp (irrelevant), PACG + Pseudophakic post SICS (small incision cataract surgery) with Enervon-C™ (irrelevant), and NTG (normal-tension glaucoma) with NutriVision™ (relevant). Conclusion: There were relevant vitamin therapies as well as irrelevant vitamin therapies in ocular diseases. Therefore, a vitamin therapy is still be argued whether it is relevant or irrelevant in ocular diseases.Keywords: vitamin therapy, ocular diseasesAbstrak: Intervensi vitamin dikenal sebagai salah satu upaya untuk mencegah kerusakan organ mata, namun tak jarang hal ini dapat menyebabkan efek samping pada mata. Penelitian ini bertujuan untuk mengetahui dampak pemberian vitamin dan relevansinya pada penyakit mata. Penelitian dilakukan di Poliklinik Ilmu Penyakit Mata BLU RSUP Prof. Dr. R. D. Kandou pada bulan November – Desember 2014 dengan metode penelitian deskriptif retrospektif. Populasi penelitian ialah 435 data rekam medik periode Juli – September 2014. Hasil penelitian memperlihatkan 5 sampel dengan riwayat terapi vitamin. Glaucoma suspect dengan terapi multivitamin NutriVision™ (relevan/tidak relevan), KSS (Kearns-Sayre syndrome) dengan terapi vitamin B1 dan B + C kompleks (relevan), PACG (primary angle closure glaucoma) + Keratopati dengan terapi vitamin B + C kompleks (tidak relevan), PACG + Pseudofakia post SICS (small incision cataract surgery) dengan terapi multivitamin Enervon-C™ (tidak relevan) dan NTG (normal-tension glaucoma) dengan terapi multivitamin NutriVision™ (relevan). Simpulan: Terdapat pemberian vitamin baik yang relevan maupun yang tidak relevan dengan penyakit mata. Pemberian vitamin masih diperdebatkan apakah relevan atau tidak dengan penyakit mata.Kata kunci: pemberian vitamin, penyakit mata

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Аntioxidant Status and Lipid Metabolism in Patients with Different Forms of Primary Open-Angle Glaucoma Progression

Малишевская

Киселева

Filippova³

et al. 2020

Oftalʹmologiâ

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Purpose: to study the antioxidant system and lipid status of serum and evaluate the effect of Cytoflavin on these characteristics in patients with progressive and stable primary open angle glaucoma (POAG).Patients and methods. 67 patients with advanced stage POAG were observed. The average age was 66.3 ± 1.5 years. According to the course of the glaucoma process all patients were randomized into 2 groups: the 1st group with the stable glaucoma (31 patients) and the 2nd group with rapidly progressive glaucoma (36 patients). The progression criteria of POAG were global ganglion cell loss volume (GLV) and perimetric index (mean deviation-MD). For assessment of the reactivity of the vascular endothelium, a test with reactive hyperemia was performed using ultrasound method. The assessment of oxidative stress (OS) including peroxides, malonyldialdehyde (MDA) and the total antioxidant capacity of serum (AOS) were evaluated. The investigations of lipid metabolism included the level of cholesterol total (CT), cholesterol of low-density lipoproteins cholesterol (LDL-C), high-density lipoproteins cholesterol (HDL-C), triglycerides (TG) and atherogenic index (AI).Results. In the 2nd group there was the significant decrease of the mean GLV indices compared to those in the 1st group (7.16 ± 2.5 и 1.06 ± 0.2, respectively, р < 0.001). The mild degree of endothelial dysfunction (ED) predominantly was detected in patients of the 1st group (69 % of cases). The moderate and marked ED were found in patients with progressive POAG (68 and 25 %, respectively). The high level of OS in serum was determined in 43 % of patients of the 1st group and in 69 % of patients of the 2nd group (significant increase of peroxides and MDA). In patients with progressive POAG the mean indices of lipid metabolism (CT, LDL-C, HDL-C, TG, AI) were significantly higher than in healthy subjects (р < 0.001). Cytoflavin had a positive effect on the vascular endothelium function, normalization of lipid metabolism and decrease of OS in serum with increasing AOS in patients with progressive POAG.Conclusion. The assessment of the indices of OS, AOS and lipid metabolism enable us to determine the risk of progression of POAG and evaluate of the effectiveness of treatment.

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Homocysteine in the Pathogenesis of Chronic Glaucoma

Cited by 3 publications

References 90 publications

Highlights on Genetic Polymorphism Associated with Thromboembolic Risk; Implications in Ophthalmic and Autoimmune Disorders—A Review

Highlights on Genetic Polymorphism Associated with Thromboembolic Risk; Implications in Ophthalmic and Autoimmune Disorders—A Review

Pemberian Vitamin Pada Penyakit Mata

Аntioxidant Status and Lipid Metabolism in Patients with Different Forms of Primary Open-Angle Glaucoma Progression

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