Association of physical activity and polymorphisms in FGFR2 and DNA methylation related genes with breast cancer risk

Xi, Jing; Su, Yi; Fadiel, Alicia Beeghly; Lin, Ying; Su, Feng; Jia, Wei Hua; Tang, Lu; Ren, Zi

doi:10.1016/j.canep.2014.09.002

Cited by 15 publications

(5 citation statements)

References 36 publications

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“…The populations surveyed in the nine rs16999593 (T/C) studies were all Chinese [6, 7, 9–15]. In the rs2228611 (G/A) studies, nine of the populations were Chinese [6, 7, 10, 11, 13, 14, 19–21], one was Iranian [8], and one was Polish [18]. In the rs2228612 (A/G) studies the populations were either Caucasian [16] or Chinese [7, 17].…”

Section: Resultsmentioning

confidence: 99%

A Meta-Analysis of the Association between DNMT1 Polymorphisms and Cancer Risk

Liu

Sun

et al. 2017

BioMed Research International

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Previous studies have examined the associations of DNA methyltransferase 1 (DNMT1) polymorphisms, including single nucleotide polymorphisms rs16999593 (T/C), rs2228611 (G/A), and rs2228612 (A/G), with cancer risk. However, the results are inconclusive. The aim of this meta-analysis is to elucidate the associations between DNMT1 polymorphisms and cancer susceptibility. The PubMed, Embase, Web of Science, and Chinese National Knowledge Infrastructure databases were searched systematically to identify potentially eligible reports. Odd ratios and 95% confidence intervals were used to evaluate the strength of association between three DNMT1 polymorphisms and cancer risk. A total of 16 studies were finally included in the meta-analysis, namely, nine studies of 3378 cases and 4244 controls for rs16999593, 11 studies of 3643 cases and 3866 controls for rs2228611, and three studies of 1343 cases and 1309 controls for rs2228612. The DNMT1 rs2228612 (A/G) polymorphism was significantly related to cancer risk in the recessive model. The meta-analysis also suggested that DNMT1 rs16999593 (T/C) may be associated with gastric cancer, while rs2228611 (G/A) may be associated with breast cancer. In future research, large-scale and well-designed studies are required to verify these findings.

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Section: Resultsmentioning

confidence: 99%

A Meta-Analysis of the Association between DNMT1 Polymorphisms and Cancer Risk

Liu

Sun

et al. 2017

BioMed Research International

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“…In consonance, the neglectful condition has been associated with having a preterm birth ( Sulaiman et al, 2021 ) with lower birth weight ( Strathearn et al, 2001 ) and with developing obesity over the life course ( Danese and Tan, 2014 ; Strathearn et al, 2020 ). ZFP57 ( Chen et al, 2019 ), FGFR2 ( Xi et al, 2014 ), and WNK4 ( Fackler et al, 2011 ), have been related to breast cancer, and WNK4 also with hypertension ( Mu et al, 2011 ; Ching et al, 2021 ) associated with suffering coronary heart disease ( Deschênes et al, 2021 ), conditions that are common among the long-term consequences of the abuse and neglect ( Strathearn et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

The shared mother-child epigenetic signature of neglect is related to maternal adverse events

et al. 2022

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Studies of DNA methylation have revealed the biological mechanisms by which life adversity confers risk for later physical and mental health problems. What remains unknown is the “biologically embedding” of maternal adverse experiences resulting in maladaptive parenting and whether these epigenetic effects are transmitted to the next generation. This study focuses on neglectful mothering indexed by a severe disregard for the basic and psychological needs of the child. Using the Illumina Human Methylation EPIC BeadChip in saliva samples, we identified genes with differentially methylated regions (DMRs) in those mothers with (n = 51), versus those without (n = 87), neglectful behavior that present similar DMRs patterns in their children being neglected versus non-neglected (n = 40 vs. 75). Mothers reported the emotional intensity of adverse life events. After covariate adjustment and multiple testing corrections, we identified 69 DMRs in the mother epigenome and 42 DMRs in the child epigenome that were simultaneously above the α = 0.01 threshold. The common set of nine DMRs contained genes related to childhood adversity, neonatal and infant diabetes, child neurobehavioral development and other health problems such as obesity, hypertension, cancer, posttraumatic stress, and the Alzheimer’s disease; four of the genes were associated with maternal life adversity. Identifying a shared epigenetic signature of neglect linked to maternal life adversity is an essential step in breaking the intergenerational transmission of one of the most common forms of childhood maltreatment.

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“…Aberrant gene methylation has been proposed to be a new prognostic marker for TC [31]. Accumulating studies have provided enough evidence on how DNA methylation and gene polymorphisms are commonly linked to the differences in surgery efficacy for many cancers [41–44]. …”

Section: Discussionmentioning

confidence: 99%

The correlations between DNA methylation and polymorphisms in the promoter region of the human telomerase reverse transcriptase (hTERT) gene with postoperative recurrence in patients with thyroid carcinoma (TC)

Zheng

Wang

2017

World J Surg Onc

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BackgroundThis study aims at exploring the correlations between DNA methylation and polymorphisms in the promoter region of the human telomerase reverse transcriptase (hTERT) gene and postoperative recurrence in patients with thyroid carcinoma (TC).MethodsA total of 312 patients diagnosed with TC were chosen for the study and categorized into recurrence (n = 75) and non-recurrence (n = 237) groups. The hTERT rs2736100 and rs2736098 polymorphisms were detected by performing polymerase chain reaction-restriction fragment length polymorphism. DNA methylation in the promoter region of hTERT gene was evaluated by pyrosequencing. A telephonic and/or outpatient follow-up was conducted for all patients. The correlations of DNA methylation and polymorphisms in the promoter region of hTERT with postoperative recurrence of TC patients underwent analysis.ResultsThe patient in the recurrence group showed evidently different pathological types and tumor stages in comparison to the non-recurrence group. The GG genotype of hTERT rs2736100 might increase the recurrence risk of TC patients. No correlations between hTERT rs2736098 polymorphisms and recurrence risk were observed. Compared to the TT + TG genotype frequency, the rs2736100 GG genotype frequency increased in patients without multicentricity, patients with extrathyroidal invasion, patients with lymph node metastasis, patients with undifferentiated carcinoma, and patients in the III + IV stage. The recurrence group showed significantly higher DNA methylation level compared to the non-recurrence group. The DNA methylation level was closely associated to tumor stage and lymph node metastasis of TC patients in the recurrence group.ConclusionsThe DNA methylation and rs2736100 polymorphisms in the promoter region of hTERT gene might be in correlation to postoperative recurrence of TC patients.

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Association of physical activity and polymorphisms in FGFR2 and DNA methylation related genes with breast cancer risk

Cited by 15 publications

References 36 publications

A Meta-Analysis of the Association between DNMT1 Polymorphisms and Cancer Risk

A Meta-Analysis of the Association between DNMT1 Polymorphisms and Cancer Risk

The shared mother-child epigenetic signature of neglect is related to maternal adverse events

The correlations between DNA methylation and polymorphisms in the promoter region of the human telomerase reverse transcriptase (hTERT) gene with postoperative recurrence in patients with thyroid carcinoma (TC)

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