Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010

Wan, En-Tzu; Darssan, Darsy; Karatela, Shamshad; Reid, Sacha; Osborne, Nicholas J.

doi:10.3390/ijerph181910249

Cited by 19 publications

(15 citation statements)

References 33 publications

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“…In Thailand, a study found that rice farmers had significantly lower MCH and MCHC values [ 23 ], whereas other studies have found no difference in the CBC parameters for pesticide-using farmers [ 26 , 27 ]. These inconsistent results may be due to differences in the pesticide type, frequency, and duration in each study, as well as differences in individual immune responses [ 31 ]. Our findings indicated a higher risk of blood disorders such as anemia for vegetable farmers who are repeatedly exposed to pesticides, particularly men.…”

Section: Discussionmentioning

confidence: 99%

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The Hematological and Biochemical Effects from Pesticide Exposure on Thai Vegetable Farmers

Bunsri,

Muenchamnan,

Naksen

et al. 2023

Toxics

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Pesticide-related health concerns are a global public health issue. Few studies in Thailand have explored the hematological and biochemical effects of occupational pesticide exposure. The goal of this study was to investigate the effects of pesticides on the hematology, hepatic, and renal function of Thai vegetable farmers. A cross-sectional study was carried out in Chiang Mai, northern Thailand. A total of 124 apparently healthy vegetable farmers were interviewed about their lifetime exposure to agricultural pesticides. Blood samples were collected via venipuncture to be tested for complete blood count (CBC), liver function, and kidney function. Approximately 46% of the farmers were pesticide users who reported a history of pesticide use for their crops, while 54% were non-pesticide users. In the male farmers, the activities of aspartate aminotransferase (AST), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were significantly higher in the pesticide users compared to the non-pesticide users, while the estimated glomerular filtration rate (eGFR), hematocrit (HCT), and red blood cells (RBC) were significantly lower (p < 0.05). In the females, the pesticide users had significantly higher levels of alanine aminotransferase (ALT), alkaline phosphatase (ALP), and MCHC than the non-pesticide users (p < 0.05). Pesticide use among Thai vegetable farmers may cause hematological alterations and increase the risk of hepatic and renal dysfunction. Some hematological and biochemical parameters may be used for monitoring to protect them from the adverse health effects of occupational exposure to pesticides.

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Section: Discussionmentioning

confidence: 99%

“…According to literature reviews, pesticide exposure is a risk factor for the development of nephrotoxic effects, which include diminished renal function and chronic kidney disease (CKD) [ 28 , 29 , 30 , 31 ]. Exposure to certain pesticides may also increase the risk of end-stage renal disease [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

The Hematological and Biochemical Effects from Pesticide Exposure on Thai Vegetable Farmers

Bunsri,

Muenchamnan,

Naksen

et al. 2023

Toxics

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“…It is well known that MT exposure triggers kidney dysfunctions, characterized by alterations of urea, creatinine, TP, and ALB levels and structural modifications in the kidney tissues (Badr 2020 ). On the other hand, organophosphates are implicated in CKD development (Wan et al 2021 ). Hypertension is documented as one of the risk features of CKD (Levey and Coresh 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Rutin protects against gamma-irradiation and malathion-induced oxidative stress and inflammation through regulation of mir-129-3p, mir-200C-3p, and mir-210 gene expressions in rats’ kidney

Ismail

Salem

Eassawy

2023

Environ Sci Pollut Res

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Kidney injury represents a global concern, leading to chronic kidney disease. The organophosphate insecticide malathion (MT) demonstrates environmental disturbance and impairment of different mammalian organs, including kidneys. Likewise, gamma-irradiation (IRR) provokes destructive effects in the kidneys. Rutin is a flavonoid glycoside that exhibits nephro-protective and radio-protective properties. This manuscript focused on investigating the protective response of rutin on MT- and IRR-triggered kidney injury in rats. Rats were randomly divided into eight groups of twelve: G1 (C), control; G2 (Rutin), rutin-treated rats; G3 (IRR), gamma-irradiated rats; G4 (MT), malathion-treated rats; G5 (IRR/MT), gamma-irradiated rats treated with malathion; G6 (IRR/Rutin), gamma-irradiated rats treated with rutin; G7 (MT/Rutin), rats treated with malathion and rutin; and G8 (IRR/MT/Rutin), gamma-irradiated rats treated with malathion and rutin, every day for 30 days. The results demonstrated that rutin treatment regulated the biochemical parameters, the oxidative stress, the antioxidant status, and the inflammatory responses due to the down-regulation of the renal NF-κB p65 protein expression. Moreover, it amended the activity of acetylcholinesterase (AchE), angiotensin ACE I, and ACE II-converting enzymes. Besides, it regulated the iNOS, eNOS, miR-129-3p, miR-200c, and miR-210 gene expressions and bradykinin receptor (B1R and B2R) protein expressions. Histopathological examinations of the kidney tissue confirmed these investigated results. It could be concluded that rutin demonstrated nephro/radioprotection and counteracted the toxicological effects triggered in the kidney tissues of IRR, MT, and IRR/MT intoxicated rats, via regulating miR-129-3p, miR-200c-3p, and miR-210-3p gene expressions, which consequently regulated B2R protein expressions, ACE II activity, and HIF-1α production, respectively.

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“…In the context of previous studies, numerous potential confounding factors that could confound the relationship between OPPs and SHyper have been incorporated into the multivariate model [36][37][38]. The covariate data from the NHANES dataset include age, gender (Male, Female), race (Mexican American, Other Hispanic, Non-Hispanic White, Non-Hispanic Black, Other Race -Including Multi-Racial), body mass index (BMI) (< 25 kg/m2, 25 to < 30 kg/m2, ≥ 30 kg/m2), education level (High school and below, High school and above), family income (< 20,000$, 20,000$ and above), and serum creatinine (mg/dL).…”

Section: Other Variablesmentioning

confidence: 99%

The association between urinary levels of organic phosphorus insecticide exposure and subclinical thyroid disorders

Shen,

Xiong,

Zhou

et al. 2024

Preprint

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Objective Studies have shown that exposure to organophosphorus pesticides (OPPs) may disrupt thyroid endocrine function in animal models and in agroforestry practitioners, leading to subclinical hyperthyroidism (SHyper). However, the relationship between exposure to OPPs and SHyper in the general population remains unclear. This research aims to investigate the relationship between OPPs exposure and SHyper in the general population. Methods This was a cross-sectional study involving data from three cycles of the National Health and Nutrition Examination Survey (NHANES), which ultimately analysed 4779 participants who met the inclusion criteria. OPPs exposure was estimated by measuring urinary composition of two OPPs metabolites (3,5,6-trichloropyridinol and paranitrophenol). Logistic regression models were employed to assess the correlation between OPPs metabolites and SHyper. Subgroup analyses were conducted based on gender, age, and body mass index (BMI), and interactions with OPPs were investigated. Results The adjusted logistic regression model showed that p-nitrophenol (PNP) was significantly and positively correlated with SHyper. PNP was positively associated with SHyper in the third and highest quartile groups compared with patients in the lowest quartile. Subgroup analyses found that both OPPs metabolites were associated with SHyper in the elderly and in those with a BMI less than 25. In addition, PNP was significantly associated with SHyper in females and those with a BMI greater than 30. With respect to SHyper, there were interactions between metabolites of OPPs and BMI and between PNP and sex. Conclusions Our study suggests that exposure to PNP and 3,5,6-trichloropyridinol (TCPy) may increase the risk of SHyper, highlighting the potential role of exposure to OPPs in SHyper.

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Association of Pesticides and Kidney Function among Adults in the US Population 2001–2010

Cited by 19 publications

References 33 publications

The Hematological and Biochemical Effects from Pesticide Exposure on Thai Vegetable Farmers

The Hematological and Biochemical Effects from Pesticide Exposure on Thai Vegetable Farmers

Rutin protects against gamma-irradiation and malathion-induced oxidative stress and inflammation through regulation of mir-129-3p, mir-200C-3p, and mir-210 gene expressions in rats’ kidney

The association between urinary levels of organic phosphorus insecticide exposure and subclinical thyroid disorders

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