Association of parvovirus B19 infection with idiopathic collapsing glomerulopathy

Moudgil, Asha; Nast, Cynthia C.; Bagga, Arvind; Wei, Lin; Amet, Nurmamet; Cohen, Arthur H.; Jordan, Stanley C.; Toyoda, Mieko

doi:10.1046/j.1523-1755.2001.00727.x

Cited by 194 publications

(118 citation statements)

References 34 publications

(7 reference statements)

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“…The pathologic variants and percentage of sclerotic glomeruli were also comparable between the two groups. These findings indicated that IgM deposition is not likely the initiation of FSGS lesion, which has been identified as several genes mutations or variants (9-13), circulating permeability factors (14)(15)(16), and others (17)(18)(19)(20)(21)(22)(23). However, IgM and complement-mediated injury may be secondary phenomena that occur after the primary renal insult.…”

Section: Discussionmentioning

confidence: 97%

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Clinical Significance of IgM and C3 Glomerular Deposition in Primary Focal Segmental Glomerulosclerosis

Zhang

Huang

et al. 2016

CJASN

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Background and objectives Glomerular IgM deposition is commonly shown in primary FSGS and sometimes accompanied by C3 deposition. Clinical presentation and treatment outcomes of these patients are not investigated in detail.Design, setting, participants, &measurements One hundred six consecutive patients with biopsy-proven primary FSGS from 2004 to 2014 were enrolled retrospectively. Clinical features and treatment outcomes were compared between patients with and without IgM/C3 deposition.Results Fifty-eight (54.7%) patients presented with IgM glomerular deposition on sclerotic segments. C3 and C1q depositions were shown exclusively in patients with IgM deposition (34.5% versus 0.0%; P,0.001 and 8.6% versus 0.0%; P=0.04, respectively). Patients with IgM deposition were younger (median; range: 24.5; 18.8-39.0 versus 46.5; 26.0-64.0 years old; P=0.001), had higher level of serum IgM (142.5;.0 versus 107.0; 71.0-140.0 mg/dl; P=0.01), and had higher level of eGFR (median; range 97.7; 48.0-135.8 versus 62.1; 33.7-93.9 ml/min per 1.73 m 2 ; P=0.01) at the time of kidney biopsy. The percentage of sclerosis lesions was significantly higher in patients with C3 deposition (median; range: 21.7%; 15.3%-31.1% versus 9.2%; 6.6%-20.0%; P=0.002). Although patients received comparable immunosuppressive treatments during 58.9 (29.5-81.1) months of follow-up, a significantly higher prevalence of refractory cases (no response or steroid dependent) occurred in patients with combined IgM and C3 deposition compared with patients with IgM deposition alone or without IgM deposition (58.8% versus 22.2% versus 15.6%, respectively; P=0.004). Multivariate analysis identified combined IgM and C3 deposition (odds ratio, 11.32; 95% confidence interval, 2.26 to 56.65; P=0.003) as an independent risk factor for refractory patients; 19 of 98 patients developed renal dysfunction when their serum creatinine levels increased .30% from baseline and reached .1.5 mg/dl. Combined IgM and C3 deposition (hazard ratio, 5.67; 95% confidence interval, 1.34 to 23.84; P=0.02) was identified as an independent risk factor for renal dysfunction.Conclusions Patients with primary FSGS and IgM and C3 deposition showed unfavorable therapeutic responses and worse renal outcomes, which indicate that IgM and C3 deposition might involve disease progression via complement activation.

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Section: Discussionmentioning

confidence: 97%

“…The eGFR was calculated with the Modification of Diet in Renal Disease Study equation adjusted for the Chinese population: eGFR=1753(serum creatinine) 21.234 3 age 20.179 30.79 (if a woman) (6).…”

Section: Patientsmentioning

confidence: 99%

Clinical Significance of IgM and C3 Glomerular Deposition in Primary Focal Segmental Glomerulosclerosis

Zhang

Huang

et al. 2016

CJASN

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“…Complex genetic factors are undoubtedly critical to the development of non-Mendelian podocyte disease, including disease triggered by environmental factors. It has been suggested, for example, that parvovirus infection is associated with the development of FSGS (99,100). HIV infection is associated with a distinct podocytopathy (see review by Ross and Klotman in this issue [101]).…”

Section: Sporadic Fsgsmentioning

confidence: 99%

Inherited Podocytopathies

Pollak¹

2002

Journal of the American Society of Nephrology

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“…FSGS affects African Americans to a disproportionate extent. FSGS may be associated with viral infections, including HIV-1 (20) and possibly parvovirus B19 (21,22).…”

mentioning

confidence: 99%

Molecular Identification of SV40 Infection in Human Subjects and Possible Association with Kidney Disease

Li¹,

Branton²,

Tanawattanacharoen³

et al. 2002

Journal of the American Society of Nephrology

121

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Abstract. Simian virus 40 (SV40), a monkey polyomavirus that is believed to have entered the human population through contaminated vaccines, is known to be renotropic in simians. If indeed SV40 is endemic within the human population, the route of transmission is unknown. It was therefore hypothesized that SV40 might be renotropic in humans and be detected more frequently in samples obtained from patients with kidney diseases. This study found that typical polyomavirus cytopathic effects (CPE) were present and SV40

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Association of parvovirus B19 infection with idiopathic collapsing glomerulopathy

Abstract: The significantly higher prevalence of PVB19 DNA in renal biopsies and peripheral blood of CG patients suggests a specific association between PVB19 infection and CG. In susceptible individuals, renal epithelial cell infection with PVB19 may induce CG.

Cited by 194 publications

References 34 publications

Clinical Significance of IgM and C3 Glomerular Deposition in Primary Focal Segmental Glomerulosclerosis

Clinical Significance of IgM and C3 Glomerular Deposition in Primary Focal Segmental Glomerulosclerosis

Inherited Podocytopathies

Molecular Identification of SV40 Infection in Human Subjects and Possible Association with Kidney Disease

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