Association of Parents' Occupational Exposure to Cancer in Children. A Case-control Study of Acute Lymphoblastic Leukemia.

Kishi, Reiko; Katakura, Yoko; Yuasa, Junko; Miyake, Hirotsugu

doi:10.1539/joh1959.35.515

Cited by 18 publications

(20 citation statements)

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“…Although most studies assessed use of, or exposure to, pesticides or specific pesticide subgroups (insecticides, herbicides, fungicides), some studies also attempted to collect information on pesticide names and formulations or on target organism (Davis 1991; Dell 2004; Infante-Rivard et al 1999; Ma et al 2002; Steinbuch 1994). Nine studies considered both residential and occupational pesticide exposures (Buckley et al 1989; Dell 2004; Kishi et al 1993; Lowengart et al 1987; Meinert et al 1996, 2000; Menegaux et al 2006; Rudant et al 2007; Steinbuch 1994), and the remaining eight studies were exclusively residential. Five studies clearly specified (or explicitly assumed) whether residential pesticide exposure during pregnancy was attributable to maternal use (Davis 1991; Lowengart et al 1987; Ma et al 2002; Menegaux et al 2006; Rudant et al 2007) as opposed to household use or exposure.…”

Section: Resultsmentioning

confidence: 99%

“…Although confounding is difficult to assess because there are few established risk factors for childhood leukemia, most studies examined or adjusted for at least a range of sociodemographic and maternal characteristics. Four studies, however, explicitly assessed the potential confounding influence of maternal or childhood X-ray exposure (Dell 2004; Fajardo-Gutierrez et al 1993; Kishi et al 1993; Lowengart et al 1987). …”

Section: Resultsmentioning

confidence: 99%

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Residential Pesticides and Childhood Leukemia: A Systematic Review and Meta-Analysis

Turner¹,

Wigle²,

Krewski

2010

Environ Health Perspect

113

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ObjectiveWe conducted a systematic review and meta-analysis of previous observational epidemiologic studies examining the relationship between residential pesticide exposures during critical exposure time windows (preconception, pregnancy, and childhood) and childhood leukemia.Data sourcesSearches of MEDLINE and other electronic databases were performed (1950–2009). Reports were included if they were original epidemiologic studies of childhood leukemia, followed a case–control or cohort design, and assessed at least one index of residential/household pesticide exposure/use. No language criteria were applied.Data extractionStudy selection, data abstraction, and quality assessment were performed by two independent reviewers. Random effects models were used to obtain summary odds ratios (ORs) and 95% confidence intervals (CIs).Data synthesisOf the 17 identified studies, 15 were included in the meta-analysis. Exposures during pregnancy to unspecified residential pesticides (summary OR = 1.54; 95% CI, 1.13–2.11; I2 = 66%), insecticides (OR = 2.05; 95% CI, 1.80–2.32; I2 = 0%), and herbicides (OR = 1.61; 95% CI, 1.20–2.16; I2 = 0%) were positively associated with childhood leukemia. Exposures during childhood to unspecified residential pesticides (OR = 1.38; 95% CI, 1.12–1.70; I2 = 4%) and insecticides (OR = 1.61; 95% CI, 1.33–1.95; I2 = 0%) were also positively associated with childhood leukemia, but there was no association with herbicides.ConclusionsPositive associations were observed between childhood leukemia and residential pesticide exposures. Further work is needed to confirm previous findings based on self-report, to examine potential exposure–response relationships, and to assess specific pesticides and toxicologically related subgroups of pesticides in more detail.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Residential Pesticides and Childhood Leukemia: A Systematic Review and Meta-Analysis

Turner¹,

Wigle²,

Krewski

2010

Environ Health Perspect

113

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“…These results are in agreement with those of Wigle and collaborators [62] except for ALL and maternal pesticide exposure. The inclusion of data issued from one unpublished study [67] and of one Japanese language study [75] reporting high relative risk estimators [3.20 (0.26-170.4) and 4.0 (1. [1][2][3][4][5][6][7][8][9][10][11][12][13][14], respectively] in this other meta-analysis can partially explain this discrepancy.…”

Section: Types Of Leukaemiamentioning

confidence: 99%

Childhood leukaemia and parental occupational exposure to pesticides: a systematic review and meta-analysis

Maele-Fabry

Lantin

Hoet

et al. 2010

Cancer Causes Control

120

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The strongest evidence of an increased risk of childhood leukaemia comes from studies with maternal occupational exposure to pesticides. The associations with paternal exposure were weaker and less consistent. These results add to the evidence leading to recommend minimizing parental occupational exposure to pesticides. Our findings also support the need to rely more on studies that clearly stipulate exposure to pesticides rather than those that assume pesticide exposure because of farm/agriculture employment.

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“…Studies of parental occupational exposures and risk of childhood AML are sparse. Previous studies have been mainly conducted in Caucasian populations (Van Maele-Fabry et al, 2011; Vinson et al, 2011; Wigle et al, 2009), and little is known about leukemia risk associated with parental occupational exposures in other ethnic groups (Monge et al, 2007; Perez-Saldivar et al, 2008; Shu et al, 1988; Kishi et al, 1993; Ferreira et al, 2013) that have different work experiences (Bureau of Labor Statistics, 2016). …”

Section: Introductionmentioning

confidence: 99%

A task-based assessment of parental occupational exposure to organic solvents and other compounds and the risk of childhood leukemia in California

Metayer

Scélo

Kang

et al. 2016

Environmental Research

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Purpose Data on parental occupational exposures and risk of childhood leukemia lack specificity. Using 19 task-based job modules, we examined the relationship between occupational exposure to organic solvents and other compounds and the risk of leukemia in children. Methods Latino (48%) and non-Latino (52%) children with acute lymphoblastic leukemia (ALL; n=670), acute myeloid leukemia (AML; n=104), and controls (n=1021) were enrolled in a study in California (2000–2008). Logistic regression models were used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for socio-demographic factors. Results Among children with non-Latino fathers, none of the exposures evaluated were associated with risks of ALL and AML. In contrast, exposure to any organic solvents in Latino fathers was associated with an increased risk of childhood ALL (OR=1.48; 95% CI: 1.01–2.16); in multivariable analyses, the OR for chlorinated hydrocarbons was 2.28 (95% CI: 0.97–5.37) while the ORs were close to one for aromatic hydrocarbons, glycol ethers, and other hydrocarbon mixtures. We also observed an increased risk of ALL with exposure to combustion exhaust/polycyclic aromatic hydrocarbons (PAHs) (ORs=1.70; 95% CI: 1.16–2.57, and 1.46; 95% CI: 0.94–2.26 with and without adjustment for chlorinated hydrocarbons, respectively). Moderately elevated risks of ALL were seen with exposure to metals, paints, and wood dust, although not statistically significant. An increased risk was reported for asbestos based on small numbers of exposed Latino fathers. No associations were reported between maternal exposures to any exposures and childhood ALL and AML. Conclusions Our data support associations between paternal occupational exposures to chlorinated hydrocarbons, combustion exhaust, metals, and possibly asbestos and the risk of ALL in the children of Latino fathers only.

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Association of Parents' Occupational Exposure to Cancer in Children. A Case-control Study of Acute Lymphoblastic Leukemia.

Cited by 18 publications

References 0 publications

Residential Pesticides and Childhood Leukemia: A Systematic Review and Meta-Analysis

Residential Pesticides and Childhood Leukemia: A Systematic Review and Meta-Analysis

Childhood leukaemia and parental occupational exposure to pesticides: a systematic review and meta-analysis

A task-based assessment of parental occupational exposure to organic solvents and other compounds and the risk of childhood leukemia in California

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