Association of parental obesity with cardiometabolic risk factors in their children: The CASPIAN-V study

Ejtahed, Hanieh‐Sadat; Heshmat, Ramin; Motlagh, Mohammad Esmaeil; Hasani‐Ranjbar, Shirin; Ziaodini, Hasan; Taheri, Majzoubeh; Ahadi, Zeinab; Aminaee, Tahereh; Shafiee, Gita; Goodarzi, Azam; Qorbani, Mostafa; Kelishadi, Roya

doi:10.1371/journal.pone.0193978

Cited by 27 publications

(34 citation statements)

References 28 publications

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“…Regarding the association between women's BMI and CVD risk factors in their offspring, the current study reported mothers with high BMI values are predicted to have obese children, which was consistent with previous studies (64). Moreover, some cross-sectional studies in Iran and other countries reported that children with obese parents had signi cantly higher odds of obesity and elevated BP (18,65,66). This association is more attributed to the mother-offspring relationship (67).…”

Section: Discussionsupporting

confidence: 89%

Predictive Value of Women’s Weight Trajectories in Determining Familial Cardiovascular Disorders: A Family Based Longitudinal Study

Naseri

Amiri

Zareie-Shabkhaneh

et al. 2020

Preprint

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Background: Considering dynamic nature of body mass index (BMI) in women, is crucial to determine cardiovascular risks in both individual and familial levels. This study aimed to investigate the life-course trajectory pattern of women's BMI and its association with cardiovascular risk factors in them and their family members. Methods: Based on the Tehran Lipid and Glucose Study (TLGS), a total of 1356 mothers with 2976 children (51.8 % girls) aged ≤ 18 years at baseline were recruited in the current analysis and followed up for an average period of 15 years. Cardiovascular risk factors, including hypertension (HTN), dyslipidemia, diabetes mellitus (DM), and obesity were considered as outcome variables. Latent growth curve modelling (LGCM) was applied to determine women's BMI trajectories; then, logistic regression was used to investigate the associations between trajectory patterns of women and cardiovascular risk factors among whole family members.Results: Women were classified into three trajectory groups labeled as normal, overweight, and obese. Compared to women's in the normal trajectory group, those in the overweight and obesity trajectory groups had higher odds ratios for HTN, DM, and dyslipidemia (p < 0.05). In the final model, men with obese spouses showed a higher rate of HTN 1.54 (95% CI: 1.05-2.25) and DM 1.55; (95% CI: 1.00–2.44). The odds of men's obesity were higher in their obese spouses compared to normal weight ones, and the odds ratios were (OR=1.70; 95%CI: 1.10-2.62). Offspring of obese and overweight mothers were more likely to be obese than those whose mothers were normal weight. The odds ratios were (OR=2.39; 95%CI: 1.67-3.44) and (OR=4.81; 95%CI: 3.16-7.34) respectively. The corresponding value for dyslipidemia in offspring with obese mothers were 1.39 (95% CI: 1.00-1.94). Conclusions: Our results showed that women's weight status over time, play a critical role in determining cardiovascular risk, not only in them but also in their family members. The current results emphasized paying more attention to women with excessive weight to promote familial cardiovascular health in the communities.

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Section: Discussionsupporting

confidence: 89%

Predictive Value of Women’s Weight Trajectories in Determining Familial Cardiovascular Disorders: A Family Based Longitudinal Study

Naseri

Amiri

Zareie-Shabkhaneh

et al. 2020

Preprint

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“…The factors associated with excess total‐body adiposity and central adiposity may have consequences on the cardiovascular health in children and adolescents with congenital heart disease, considering that obesity, central obesity, high intakes of added sugar and trans fatty acids, and family history of obesity are associated with cardio‐metabolic markers. Previous studies report cardio‐metabolic markers altered in children and adolescents with congenital heart disease .…”

Section: Discussionmentioning

confidence: 99%

Added sugar and trans fatty acid intake and sedentary behavior were associated with excess total‐body and central adiposity in children and adolescents with congenital heart disease

et al. 2020

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Background: Over the past three decades, the prevalence rate of overweight and obesity has increased in survivors with congenital heart disease, and little is known about the body composition and its association with clinical characteristics and lifestyle factors.Objectives: To evaluate excess total-body adiposity and central adiposity and, to describe associated factors.Methods: Cross-sectional study with children and adolescents who underwent procedure to treat congenital heart disease, from January to July 2017. Sociodemographic and clinical characteristics, and lifestyle factors (dietary intake, physical activity, and sedentary behavior) were assessed. Adiposity was assessed using air-displacement plethysmography and waist circumference. Factors associated with excess total-body adiposity and central adiposity were analyzed using logistic regression models. Results: Of 232 patients, 22.4% were identified with excess total-body adiposity and 24.6% with central adiposity. Significant factors positively associated with excess total-body adiposity were intake of added sugar and trans fatty acids, adjusted for confounding factors. Similarly, lifestyle factors were positively associated with central adiposity: intake of added sugar and trans fatty acids, sedentary behavior, and family history of obesity. Conclusions: Lifestyle factors were associated with excess total-body adiposity and central adiposity. Assessment of body composition and healthy-lifestyle counseling into outpatient care may be the key point to prevent obesity in children and adolescents with congenital heart disease.

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“…Therefore, we evaluated families with longevity or early deaths, so that all members of the same family had potentially similar lifestyle behaviour. The family environment has a critical role in the development of cardiometabolic disorders (such as smoking behaviour, eating habits, obesity and hypertension) in offspring and their children [ 64 ]. Additionally, the association of support from family for adoption of healthy eating habits and performing exercise with improvements of self-leadership (defined as a process of behavioural and cognitive self-evaluation and self-influence, in which an individual achieves the self-direction and self-motivation needed to make positive changes in behaviours) is also important as shown in cancer patients [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

Biomarkers and Gene Polymorphisms in Members of Long- and Short-lived Families: A Longevity Study

Kolovou

Diakoumakou

Papazafiropoulou

et al. 2018

TOCMJ

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Background:The influence of biomarkers in human lifespan has been investigated but with no clear results yet.Materials and methods:Lipids, Uric Acid (UA), Adiponectin (ADIPOQ), Insulin-like Growth Factor (IGF-1), cholesteryl ester transfer protein (CETP) and angiotensin-converting enzyme (ACE) proteins, as well as CETP, ADIPOQ, insulin-like growth factor binding protein-3 (IGFBP3) and ACE-gene polymorphisms were evaluated in 149 Greek individuals. The Long-Lived Families (LON) (n=84) comprised of 3 generations: long-lived aged ≥90 years (P), offspring (FL1) and their grandchildren (FL2), while the Short-Lived Families (EAD) (n=65) where both parents died <75 years, comprised of 2 generations: middle-aged (FD1) and children (FD2).Results:Serum CETP and IGF-1 levels were lower, whereas AdipoQ concentrations were higher in P compared with FL1 and FL2 members (CETP: p = 0.03 for both comparisons; IGF-1 p < 0.001 for both comparisons and ADIPOQ: p = 0.001 and p = 0.004, respectively). Furthermore, serum triglycerides, UA and glucose concentrations were higher in FD1 compared with FD2 subjects (p=0.001, 0.02 and ≤0.001, respectively). In FD2 and FL2, CETP levels were lower in individuals with B2B2 compared with B1B1 genotype (p=0.007). Additionally, ACE concentrations were higher in individuals with DD compared with II genotype in both Families (p=0.001). After adjustment for age and gender, CETP levels were lower in P and FL2 individuals with B2B2 compared with the B1B1 genotype (p=0.004 and 0.007, respectively).Conclusion:Increase serum TGs, UA and GL concentrations were higher in the middle-aged individuals compared with their children in families independently of their lifespan. The serum adiponectin concentration was the highest in the oldest old individuals implying beneficial influence on lifespan. Independently of family’s lifespan history, the youngest individuals with CETPB2B2 genotype, compared with individuals with CETPB1B1 genotypes, had lower serum CETP concentrations. The knowledge of the unfavourable gene(s)influencing human lifespan may be helpful in encouraging individuals to follow healthier lifestyle habits and better control their high-risk biomarkers.

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Association of parental obesity with cardiometabolic risk factors in their children: The CASPIAN-V study

Cited by 27 publications

References 28 publications

Predictive Value of Women’s Weight Trajectories in Determining Familial Cardiovascular Disorders: A Family Based Longitudinal Study

Predictive Value of Women’s Weight Trajectories in Determining Familial Cardiovascular Disorders: A Family Based Longitudinal Study

Added sugar and trans fatty acid intake and sedentary behavior were associated with excess total‐body and central adiposity in children and adolescents with congenital heart disease

Biomarkers and Gene Polymorphisms in Members of Long- and Short-lived Families: A Longevity Study

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