Association of parental body mass index before pregnancy on infant growth and body composition: Evidence from a pregnancy cohort study in Malaysia

Zalbahar, Nurzalinda; Mohamed, Hamid Jan B. Jan; Loy, See Ling; Najman, Jake M.; McIntyre, H. David; Mamun, Abdullah Al

doi:10.1016/j.orcp.2015.08.002

Cited by 16 publications

(15 citation statements)

References 34 publications

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“…Our results are consistent with the Bider‐Canfield et al . study on childhood overweight at age 2 years ; they also align with results from two Asian cohorts, in which pre‐pregnancy BMI was positively associated with infant overweight/obesity status and WFL z‐score at 12 months of age . In our study, when breastfeeding or antibiotic exposure by 3 months of age and birth mode were taken into account, the magnitude of the association with child overweight was diminished to a much greater extent following maternal obesity than maternal overweight.…”

Section: Discussionsupporting

confidence: 89%

“…In a cohort of 955 pregnant women, of whom over 40% were overweight or had obesity prior to pregnancy, an association between pre-pregnancy overweight/obesity and child overweight (>97th centile WFL z-score) was already evident at 1 year of age. Maternal pre-pregnancy obesity presented (11); they also align with results from two Asian cohorts, in which pre-pregnancy BMI was positively associated with infant overweight/obesity status and WFL z-score at 12 months of age (13,14). In our study, when breastfeeding or antibiotic exposure by 3 months of age and birth mode were taken into account, the magnitude of the association with child overweight was diminished to a much greater extent following maternal obesity than maternal overweight.…”

Section: Discussionsupporting

confidence: 77%

“…Infant weight was higher at birth and at 13 months of age following pre‐pregnancy overweight in a Finnish study . In two Asian cohorts, maternal pre‐pregnancy body mass index (BMI) was positively associated with offspring weight for length z‐score through the first 12 months of life .…”

Section: Introductionmentioning

confidence: 99%

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Impact of maternal pre‐pregnancy overweight on infant overweight at 1 year of age: associations and sex‐specific differences

et al. 2018

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 77%

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Impact of maternal pre‐pregnancy overweight on infant overweight at 1 year of age: associations and sex‐specific differences

et al. 2018

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“…The limited number of studies that have analysed the association between parental body mass index (BMI) and toddler growth, have mostly yielded inconsistent results. 22 23 For example, Regnault et al and Knight et al reported a positive association between maternal BMI and their offspring’s birth weight and/or BMI, 24 25 whereas Stunkard et al revealed a null association at 2 years old. 23 Of the studies that have examined the impact of paternal BMI on offspring birth weight, only one reported any effect.…”

Section: Introductionmentioning

confidence: 99%

Impact of parental weight status on children’s body mass index in early life: evidence from a Chinese cohort

Hong

Guo

et al. 2018

BMJ Open

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ObjectivesTo understand whether parents’ weight status before conception predicts body mass index (BMI) of their offspring in early life and the differences between the mother–child and father–child associations.DesignA birth cohort study.SettingConducted at the Community Health Service Centre in Shenyang, Wuhan and Guangzhou.ParticipantsA total of 2220 live birth newborns were recruited randomly after consent of their parents, and 1178 were followed up until 2 years old.MethodsParental demographics, maternal characteristics during pregnancy, children’s anthropometric data and feeding patterns at 1 month old were collected. BMI was calculated and BMI Z-scores (BMI_Z) were generated by referring to WHO growth standard. Parental weight status was categorised into underweight, normal weight, and overweight and obese according to the Working Group of Obesity in China. General linear models and generalised linear models were used to assess the associations between parents and offspring.Outcome measuresThe primary outcomes were descriptive data on child’s sex-specific anthropometric variables. The secondary outcomes were BMI_Z and weight status of children at each time point.ResultsNo gender difference was observed in BMI_Z or overweight or obesity rates from birth to 24 months old, although boys were significantly heavier and had a greater length/height than girls (P<0.05). The overweight and obesity rates of children peaked at 12 months old. Maternal BMI/weight status had a significant but small effect on BMI_Z at birth, but not on the paternal side. The impact of parental BMI on child’s BMI_Z after birth was similar at each follow-up. Offspring with underweight mothers tend to have reduced BMI_Z after birth while overweight/obese fathers had children with a greater BMI_Z.ConclusionsMaternal weight status had small effect on both fetal and child growth after birth. Significant but mild paternal influence was only detected after birth.

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“…A total of 371 pregnant women is required for the study. Taking into account for a design effect of 1.119 [ 51 ] and a possible attrition rate of 28.5% [ 52 ], the sample size is increased to 533 pregnant women.…”

Section: Methodsmentioning

confidence: 99%

Contribution of early nutrition on the development of malnutrition and allergic diseases in the first year of life: a study protocol for the Mother and Infant Cohort Study (MICOS)

et al. 2018

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BackgroundNutrition and environmental factors are essential for the education of the neonatal immune system. Epidemiological evidence has shown that malnutrition and allergic diseases that occur during early childhood share similar protective and risk factors. This paper describes the protocol of the Mother and Infant Cohort Study (MICOS), which aims to determine the contribution of early nutrition to the development of malnutrition and allergic diseases in infants’ first year of life.MethodsMICOS is a prospective cohort study conducted at selected government health clinics in two states, namely Selangor and Wilayah Persekutuan Kuala Lumpur, Malaysia. Women in their third trimester of pregnancy are recruited into the study and their infants will be followed-up at 3, 6, and 12 months of age. Information on prenatal factors including socio-demographic characteristics, obstetric history, pre-pregnancy body mass index, gestational weight gain, smoking, family history of allergic diseases, maternal dietary intake and sunlight exposure during pregnancy are obtained through face-to-face interviews. Postnatal factors including dietary intake, sun exposure, and anthropometric measurements of the mothers, as well as feeding practices, dietary intake, anthropometric measurements, and development of allergic diseases of the infants are assessed at each follow-up. Blood samples are collected from the mothers in the third trimester to determine 25-hydroxyvitamin D levels as well as from the infants at age 12 months to determine atopic sensitisation.DiscussionThe concept of developmental origins of health and disease (DOHaD) which emphasises on the role of early life environments in shaping future health and disease susceptibility in adulthood has gained a huge interest in recent years. The DOHaD paradigm has influenced many fields of research including malnutrition and allergic diseases. While findings from the developed countries remain controversial, such studies are scarce in developing countries including Malaysia. The present study will determine the cause and effect relationship between early nutrition and the development of malnutrition and allergic diseases in infants’ first year of life.

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Association of parental body mass index before pregnancy on infant growth and body composition: Evidence from a pregnancy cohort study in Malaysia

Cited by 16 publications

References 34 publications

Impact of maternal pre‐pregnancy overweight on infant overweight at 1 year of age: associations and sex‐specific differences

Impact of maternal pre‐pregnancy overweight on infant overweight at 1 year of age: associations and sex‐specific differences

Impact of parental weight status on children’s body mass index in early life: evidence from a Chinese cohort

Contribution of early nutrition on the development of malnutrition and allergic diseases in the first year of life: a study protocol for the Mother and Infant Cohort Study (MICOS)

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