Association of p53 and p21 expression with clinical outcome in patients with carcinoma in situ of the urinary bladder

Shariat, Shahrokh F.; Kim, JaHong; Raptidis, Grigorios; Ayala, Gustavo; Lerner, Seth P.

doi:10.1016/s0090-4295(03)00236-x

Cited by 115 publications

(83 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Shariat el al. (19) have reported that p21 expression was associated with the recurrence and progression of urinary bladder cancer and Korkolopoulou et al (8) showed that p21 expression was an important indicator of shortened disease-free survival in astrocytoma patients. The p21 expression level may be an important prognostic factor for response to therapy and survival in acute myelogenous leukemia patients (24).…”

Section: Discussionmentioning

confidence: 99%

“…Since p53 can up-regulate p21 expression (19,21), a correlation between p53 and p21 expression can be expected. However, p53-independent induction is also known (23).…”

Section: Discussionmentioning

confidence: 99%

“…Shariat el al. (19) reported that positive p21 expression was associated with the recurrence and progression of urinary bladder cancer, although p53 expression was not associated with clinical outcome. Pruneri et al (15) suggested that the immunohistochemistry of p53 represents an adjunct in MM prognostication, but that there is no prognostic implication for p21.…”

Section: Discussionmentioning

confidence: 99%

“…The cell cycle inhibitory activity of p21 has been correlated with its nuclear localization (2). Several studies have evaluated the prognostic significance of p21 in hematopoietic (22,24) and solid (1,7,8,11,13,18,19) tumors, but the prognostic evaluation in MM remains to be explored (6,9,15).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Prognostic implications of p21 (Waf1/Cip1) immunolocalization in multiple myeloma

et al. 2005

View full text Add to dashboard Cite

Protein p21 (Waf1/Cip1) plays a critical role in controlling the cell cycle especially as a check point of G1 and is intimately associated with important cellular activities including differentiation, senescence, tumorigenesis, and apoptosis. In the present study, we examined the expression of p21 in multiple myeloma (MM) cells for prognostic evaluation. The immunocytochemical localization of p21 could be categorized into nuclear and cytoplasmic types. The nuclear-type p21 localization was correlated with the severity of MM and the expression of proliferating cell nuclear antigen and p53. Patients with the nuclear-type p21 localization survived significantly shorter than those with the cytoplasmic-type localization. Thus, the present study suggests that p21-immunolocalization can be a useful prognostic marker of MM.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Since p53 can up-regulate p21 expression (19,21), a correlation between p53 and p21 expression can be expected. However, p53-independent induction is also known (23).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Prognostic implications of p21 (Waf1/Cip1) immunolocalization in multiple myeloma

et al. 2005

View full text Add to dashboard Cite

show abstract

“…2 Bladder cancer has been shown to resist programmed cell death both with altered expression of pro-and antiapoptotic proteins. [3][4][5] Survivin is a member of the inhibitor of apoptosis (IAP) gene family that has been found to control mitotic progression and induces changes in gene expression that are associated with tumor cell invasiveness. 6,7 Survivin mRNA is selectively expressed during embryonic and fetal development, 8 becomes undetectable or expressed at low levels in most differentiated normal adult tissues, and is overexpressed in human cancers.…”

mentioning

confidence: 99%

Survivin expression is associated with bladder cancer presence, stage, progression, and mortality

Shariat

Ashfaq

Karakiewicz

et al. 2007

Cancer

136

View full text Add to dashboard Cite

BACKGROUNDThe purpose was to compare the differential expression of Survivin in normal bladder tissue, bladder transitional cell carcinoma (TCC) of different stages, and to determine whether expression of Survivin is associated with TCC clinical outcomes.METHODSImmunohistochemical staining for Survivin was carried out on archival bladder specimens from 9 normal controls and 222 consecutive patients who underwent radical cystectomy and bilateral lymphadenectomy. Lymph node tissue involved with TCC from 50 of the 222 cystectomy patients was also evaluated.RESULTSSurvivin was expressed in none of the normal bladder specimens, 64% of the cystectomy specimens, and 94% of the malignant lymph nodes. Multivariable analyses performed in the cystectomy patients revealed that Survivin expression was associated with disease recurrence (P = .040), disease‐specific mortality (P = .037), and all‐cause mortality (P = .044).CONCLUSIONSThe findings of the study provide a rationale for further evaluation of Survivin and its downstream signaling pathways in bladder cancer and raise the potential for Survivin‐targeted therapy for bladder cancer. Cancer 2007. © 2007 American Cancer Society.

show abstract

Urothelial Carcinoma in Situ

2012

View full text Add to dashboard Cite

Association of p53 and p21 expression with clinical outcome in patients with carcinoma in situ of the urinary bladder

Cited by 115 publications

References 17 publications

Prognostic implications of p21 (Waf1/Cip1) immunolocalization in multiple myeloma

Prognostic implications of p21 (Waf1/Cip1) immunolocalization in multiple myeloma

Survivin expression is associated with bladder cancer presence, stage, progression, and mortality

Urothelial Carcinoma in Situ

Contact Info

Product

Resources

About