Association of oncogenic bacteria with colorectal cancer in South China

Zhou, Youlian; He, Hanchang; Xu, Haoming; Li, Yingfei; Li, Zhiming; Du, Yanlei; He, Jie; Zhou, Yongjian; Wang, Hong; Nie, Yongzhan

doi:10.18632/oncotarget.13094

Cited by 73 publications

(68 citation statements)

References 44 publications

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“…E. faecalis is a gram‐positive facultative anaerobic bacterium. Recent research has linked E. faecalis with CRC, because the bacterium was found to aggregate at a higher level in fecal specimens from patients with CRC compared to that of healthy controls, and is more abundant in the adjacent tissues of cancer and CRC compared to healthy mucosa . In Il10 knockout mice, E. faecalis promoted colon inflammation, leading to dysplasia and CRC .…”

Section: Typical Microbial Families Contributing To Colorectal Cancermentioning

confidence: 99%

“…Recent research has linked E. faecalis with CRC, because the bacterium was found to aggregate at a higher level in fecal specimens from patients with CRC compared to that of healthy controls, and is more abundant in the adjacent tissues of cancer and CRC compared to healthy mucosa. 52 In Il10 knockout mice, E. faecalis promoted colon inflammation, leading to dysplasia and CRC. 53 One study also showed that E. faecalis, which can cause colitis after infection, can express TGF-β in the intestinal epithelial cells of wild-type mice, thereby activating the Smad signaling pathway.…”

Section: Typical Microbial Families Contributing To Colorectal Cancermentioning

confidence: 99%

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The role of microbiota in the development of colorectal cancer

Dai

Zhang

et al. 2019

Intl Journal of Cancer

100

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Colorectal cancer is the third largest cancer in worldwide and has been proven to be closely related to the intestinal microbiota. Many reports and clinical studies have shown that intestinal microbial behavior may lead to pathological changes in the host intestines. The changes can be divided into epigenetic changes and carcinogenic changes at the gene level, which ultimately promote the production and development of colorectal cancer. This article reviews the pathways of microbial signaling in the intestinal epithelial barrier, the role of microbiota in inflammatory colorectal tumors, and typical microbial carcinogenesis. Finally, by gaining a deeper understanding of the intestinal microbiota, we hope to achieve the goal of treating colorectal cancer using current microbiota technologies, such as fecal microbiological transplantation.

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Section: Typical Microbial Families Contributing To Colorectal Cancermentioning

confidence: 99%

Section: Typical Microbial Families Contributing To Colorectal Cancermentioning

confidence: 99%

The role of microbiota in the development of colorectal cancer

Dai

Zhang

et al. 2019

Intl Journal of Cancer

100

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“…Other factors related to cancer development are the size or the number of polyps detected as well the presence of dysplasia in the polyp after surgical removal. Recently, several studies have suggested a connection between the imbalance of intestinal flora and the emergence of adenomatous colon polyps and CRC [ 20 , 48 , 49 , 50 , 51 ]. Microorganisms located in the intestines play a crucial role in food digestion, vitamin biosynthesis, and protection against pathogens.…”

Section: Colon Cancer and Adenomatous Colon Polypsmentioning

confidence: 99%

An Overview of Gut Microbiota and Colon Diseases with a Focus on Adenomatous Colon Polyps

Pop

Vodnar

Diaconeasa

et al. 2020

IJMS

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It is known and accepted that the gut microbiota composition of an organism has an impact on its health. Many studies deal with this topic, the majority discussing gastrointestinal health. Adenomatous colon polyps have a high prevalence as colon cancer precursors, but in many cases, they are hard to diagnose in their early stages. Gut microbiota composition correlated with the presence of adenomatous colon polyps may be a noninvasive and efficient tool for diagnosis with a high impact on human wellbeing and favorable health care costs. This review is meant to analyze the gut microbiota correlated with the presence of adenomatous colon polyps as the first step for early diagnosis, prophylaxis, and treatment.

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“…С болезнью Крона и язвенным колитом ассоциированы инвазивные штаммы E. coli, K. pneumonia и Helicobacter spp., а с колоректальным раком -B. fragilis, pks + E. coli, E. faecalis. [12][13][14][15][16]. В работе Y. Zhou и соавт.…”

Section: кишечникunclassified

“…В работе Y. Zhou и соавт. было показано, что в опухолевых тканях пациентов, страдающих колоректальным раком (CRC), повышено количество E. faecalis и B. fragilis по сравнению с тканями толстой кишки здоровых доноров [16]. Также выполнены исследования, показывающие, что у пациентов с CRC происходит увеличение доли бактерий, относящихся к родам Enterococcus, Escherichia, Shigella, Peptostreptococcus, Streptococcus, Klebsiella и группе Bacteroides-Prevotella по сравнению с контролем.…”

Section: кишечникunclassified

The human bacterial microflora composition: genotoxic and carcinogeneous effects associated with its changes in various organs

Baranova¹,

Дружинин²

2019

Mol. genet. mikrobiol. virusol.

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Состав бактериальной микрофлоры человека: генотоксические и канцерогенные эффекты, ассоциированные с его изменениями в различных органах Е.Д. БАРАНОВА, В.Г. ДРУЖИНИН ФГБОУ ВО «Кемеровский государственный университет», 650000, Кемерово, Россия РЕЗЮМЕ Бактериальная микрофлора, населяющая наш организм, составляет сложнейшее сообщество микроорганизмов, называемое микробиотой. Эволюционно закрепившаяся в организме человека микробиота значимо влияет на поддержание здоровья и функций жизнедеятельности человека. До настоящего времени без должного внимания остается изучение генотоксического потенциала микрофлоры, тесно связанного с бактериальным онкогенезом. При нарушении баланса здоровой микрофлоры под действием различных факторов, в том числе мутагенов и канцерогенов окружающей среды, происходит трансформация состава микробиоты в «агрессивную» форму. Есть предположения, что такие изменения приводят к функциональным сдвигам метаболизма в бактериальных сообществах, что ведет к прогрессии злокачественного роста в этих участках организма-хозяина. Бактерии способны влиять на патогенетические процессы, протекающие в ходе заболевания, продуцируя эффекторы повреждения ДНК в клетках организма-хозяина или модифицируя способность организма к метаболизму мутагенов и канцерогенов. В данном обзоре мы представляем фактологию и гипотезы о способности патогенных и комменсальных бактерий с генотоксическим потенциалом приводить к развитию онкологических заболеваний. В обзоре рассмотрены отдельные органы (кишечник, желудок, респираторный тракт, желчный пузырь и молочная железа), в канцерогенезе которых известно влияние бактерий, способных повреждать ДНК клеток хозяина.Ключевые слова: состав микробиоты человека, бактериальные генотоксины, повреждения ДНК, мутагенез, канцерогенез. ИНФОРМАЦИЯ ОБ АВТОРАХ: Баранова Елизавета Дмитриевна -

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Association of oncogenic bacteria with colorectal cancer in South China

Abstract: To quantify Fusobacterium spp., Enterococcus faecalis (E.faecalis), Enterotoxigenic Bacteroides fragilis (ETBF), and Enteropathogenic

Cited by 73 publications

References 44 publications

The role of microbiota in the development of colorectal cancer

The role of microbiota in the development of colorectal cancer

An Overview of Gut Microbiota and Colon Diseases with a Focus on Adenomatous Colon Polyps

The human bacterial microflora composition: genotoxic and carcinogeneous effects associated with its changes in various organs

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