Association of obesity and its genetic predisposition with the risk of severe COVID-19: Analysis of population-based cohort data

Zhu, Zhaozhong; Hasegawa, Kohei; Ma, Baoshan; Fujiogi, Michimasa; Camargo, Carlos A.; Liang, Liming

doi:10.1016/j.metabol.2020.154345

Cited by 74 publications

(77 citation statements)

References 38 publications

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“… 29 A cohort study that recruits 489,769 people in England has shown that higher BMI is associated with higher risk of severe COVID-19 (adjusted ORs: 1.40 for 25.0–29.9 kg/m 2 , 1.73 for 30.0–34.9 kg/m 2 , 2.82 for 35.0–39.9 kg/m 2 ,and 3.30 for ≥40.0 kg/m 2 ). 30 Similar result was reported in Spain. 31 More importantly, BMI >30 kg/m 2 was associated with an increased risk of death.…”

Section: Obesity Is Associated With Disease Severity and Outcomesupporting

confidence: 79%

<p>COVID-19 and Obesity: Epidemiology, Pathogenesis and Treatment</p>

Zhu¹,

Liu²,

Huang³

2020

DMSO

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The growing prevalence of overweight and obesity has been a worldwide public health issue. During the COVID-19 pandemic, obesity is associated with a higher risk of severity and a worse clinical outcome of SARS-COV-2 infection. This may be because of the chronic low-grade inflammation, impaired immune response and metabolic disorders in obese patients. In this narrative review, we have summarized the association between obesity and COVID-19 and discussed the potential pathogenesis and treatment in these patients. This work may provide practical suggestions on the clinical management of obese COVID-19 patients.

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Section: Obesity Is Associated With Disease Severity and Outcomesupporting

confidence: 79%

<p>COVID-19 and Obesity: Epidemiology, Pathogenesis and Treatment</p>

Zhu¹,

Liu²,

Huang³

2020

DMSO

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“…Central obesity is defined as a state of excessive VAT accumulation [66]. Patients with central obesity evidenced by waist circumference or waist-to-hip ratio were also found to be more likely to develop severe COVID-19 (P<0.001) in a large population-based cohort [67]. Our primary analysis also demonstrates a more VAT accumulation among patients with severe COVID-19.…”

Section: Discussionmentioning

confidence: 51%

Obesity in patients with COVID-19: a systematic review and meta-analysis

et al. 2020

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Background: Obesity is common in patients with coronavirus disease 2019 (COVID-19). The effects of obesity on clinical outcomes of COVID-19 warrant systematical investigation. Objective: This study explores the effects of obesity with the risk of severe disease among patients with COVID-19. Methods: Body mass index (BMI) and degree of visceral adipose tissue (VAT) accumulation were used as indicators for obesity status. Publication databases including preprints were searched up to August 10, 2020. Clinical outcomes of severe COVID-19 included hospitalization, a requirement for treatment in an intensive care unit (ICU), invasive mechanical ventilation (IMV), and mortality. Risks for severe COVID-19 outcomes are presented as odds ratios (OR) and 95% confidence interval (95%CI) for cohort studies with BMI-defined obesity, and standardized mean difference (SMD) and 95%CI for controlled studies with VAT-defined excessive adiposity. Results: A total of 45, 650 participants from 30 studies with BMI-defined obesity and 3 controlled studies with VAT-defined adiposity were included for assessing the risk of severe COVID-19. Univariate analyses showed significantly higher ORs of severe COVID

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“…It has been suggested that obesity is related to high morbidity and/or mortality rates in COVID-19 patients in previous studies [ 9 , 13 , 19 , 20 ]. Obesity could be linked to the severity of COVID-19 via metabolic dysregulation, immune impairments and adiposopathy with altered adipokine levels, such as increased leptin and decreased adiponectin concentrations [ 13 , 19 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Mortality and Morbidity in COVID-19 Patients with Obesity Using Clinical Epidemiological Data from the Korean Center for Disease Control & Prevention

Kim

Yoo

Min

et al. 2020

IJERPH

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Previous studies have reported the association of obesity with increased morbidity or mortality due to the coronavirus disease 2019 (COVID-19). This study aims to investigate the relationship of obesity, as defined by the body mass index (BMI), with morbidity and mortality due to COVID-19. Data from 5628 confirmed COVID-19 patients were collected by the Centers for Disease Control and Prevention of Korea. The hazard ratios (HRs) for mortality in the BMI groups were analyzed using the Cox proportional hazard model adjusted for covariates. The odds ratios (ORs) of morbidity and diabetes in the BMI groups were analyzed using logistic regression adjusted for the same covariates. Both underweight and obesity were associated with a higher HR for mortality (adjusted HR = 2.28, 95% confidence intervals [95% CI] = 1.23–4.25, p = 0.009 for underweight and adjusted HR = 1.71, 95% CI = 1.10–2.66, p = 0.017 for obese). Obesity was related to higher odds of morbidity (adjusted OR = 1.71, 95% CI = 1.32–2.21, p < 0.001). Underweight and obesity were associated with high mortality and/or morbidity due to COVID-19 in Korea.

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Association of obesity and its genetic predisposition with the risk of severe COVID-19: Analysis of population-based cohort data

Cited by 74 publications

References 38 publications

<p>COVID-19 and Obesity: Epidemiology, Pathogenesis and Treatment</p>

<p>COVID-19 and Obesity: Epidemiology, Pathogenesis and Treatment</p>

Obesity in patients with COVID-19: a systematic review and meta-analysis

Analysis of Mortality and Morbidity in COVID-19 Patients with Obesity Using Clinical Epidemiological Data from the Korean Center for Disease Control & Prevention

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