Association of novel single nucleotide polymorphisms of the CXCR1 gene with the milk performance traits of Chinese native cattle

Single nucleotide polymorphisms in the CXCR1 gene and its association with clinical mastitis incidence in Polish Holstein-Friesian cows

“…On the other hand, Zhou et al (2013) revealed a significant association of TT genotype for this mutation (and also AA genotype for c.337A<G mutation, not found in the present study) with higher SCS and a suggested possible role of these two mutations in the host response against mastitis. This discrepancy in the obtained results indicates the need for further research to verify the influence of the c.365T>C mutation on mastitis in cows.…”

“…In addition, the c.+816C>A and c.+819G>A mutations were described by Youngerman et al (2004a,b) as +858 and +861, respectively. Zhou et al (2013) found four polymorphisms within the exon II sequence of the CXCR1 gene in Chinese native cattle and two of them (c.+291C>T and c.+365T>C) were also identified in this study.…”

“…They only observed an increased resistance to mastitis caused by certain pathogens (i.e., major pathogens: Staphylococcus aureus, S. agalactiae, S. dysgalactiae, and esculin-positive streptococci) in cows with genotype AG instead of GG at position c.980. The association of the individual mutations and combined genotypes of the CXCR1 gene (formed by four identified SNP mutations: c.291C>T, c.333C>T, c.337A>G, and c.365C>T) with reduced SCS was found by Zhou et al (2013).…”

“…For example, Pighetti et al (2012) identified 36 SNPs within the coding and non-coding regions of this gene, whereas Verbeke et al (2012) found 16 polymorphisms in the coding region alone, of which six had not previously been reported. The CXCR1 gene was proposed as a potential genetic marker in cattle breeding programs by Zhou et al (2013), who demonstrated an association between four types of SNP mutations within the 550-bp fragment of the putative exon II region of this gene and milk traits, including SCS.…”

PCR-SSCP and Sequencing of CXCR1 (IL8RA) Gene in Indian Water Buffalo

“…SNP (one) in the coding region (Youngerman et al 2004) and one SNP in the 5' upstream region (Leyva-Baca et al, 2008) of CXCR1 were found to be associated with mastitis susceptibility in case of Holstein Cattle. Zhou et al (2013) detected 4 single nucleotide polymorphisms (SNPs) of the CXCR1 gene in Chinese native cattle and found the significant association of c.337A>G and c.365C>T with the somatic cell score, which suggests the possible role of these SNPs in the host response against mastitis. In the present study, the reason for monomorphic pattern may be due to the partial segment taken for the study.…”