Association of non-alcoholic fatty liver disease with renal stone disease detected on computed tomography

Abstract

ObjectiveTo evaluate the association between Non-alcoholic fatty liver disease (NAFLD) with renal stone disease detected on computed tomography (CT).MethodA total 1812 patients who underwent abdomen-pelvis CT in July 2015 were included in this study. The inclusion criteria for NAFLD were as follows: (i) lower average Hounsfield unit (HU) of hepatic right lobe, left medial and lateral segment when compared with that of spleen, (ii) patients who having urolithiasis in kidneys, ureters and urinary bladder, and (iii) patients underwent abdomen-pelvis CT including noncontrast image. The statistical significance of the association between NAFLD and renal stone disease was assessed using Chi Square Test. The Odds ratios and 95% CI were calculated to assess the propensity of renal stones disease for NAFLD by using Logistic Regression analysis.ResultsThe frequency of renal stone disease in patients with NAFLD was higher approximately 19% than those who having renal stone disease without NAFLD. In addition, the presence of NAFLD was linked with renal stone disease showing that detection rate of renal stone disease in patients with NAFLD was markedly high (odds ratio: 5, 95% CI, 3–8.2) (p < 0.05) in multivariate analysis.ConclusionThe presence of significant association between NAFLD with renal stone disease and NAFLD may be considered to be an independent variable as a risk factor for renal stone disease.

Incidental hepatic steatosis on unenhanced computed tomography performed for suspected renal colic: Gaps in reporting and documentation

“…There is a known association between metabolic syndrome and urolithiasis and several factors that we could not account for may have influenced our prevalence data. Recent studies reported direct association between hepatic steatosis and urolithiasis . This explains the higher prevalence of hepatic steatosis in patients with urolithiasis compared to without (Table ).…”

“…The results are presented using standard summary statistics with frequencies, percentages, means (95% CI) and median (range and interquartile [IQR] range). Prevalence data are also presented, sub‐grouped by gender and the presence of urolithiasis given the known association of urolithiasis with hepatic steatosis . Proportions of patients with and without documented steatosis in medical charts were compared using Fisher's exact test.…”

Non-alcoholic fatty liver disease and the risk of urolithiasis

“…[22] Again, a population-based retrospective study involving 1812 patients showed that the prevalence of renal stone disease in patients with NAFLD was markedly higher than those without NAFLD in multivariate analysis (OR: 5, 95% CI, 3–8.2) ( P < .05). [20] Also, a large cohort study involving 208,578 Korean adults who underwent a comprehensive health examination between January 2002 and December 2014 showed that the presence of NAFLD was significantly linked to an increased incidence of urolithiasis among in male subjects, independently of possible confounders. [21] Collectively, an increasing number of studies have shown consistent evidence that the presence of NAFLD, defined as either ultrasonography or computed tomography, was closely linked to a higher risk of urolithiasis.…”

The influence of metabolic syndrome and its components on the development of nephrolithiasis

“…Increasing visceral adipose tissue, as measured by computed tomography (CT), was reported to be associated with the risk of developing uric acid and calcium oxalate stones [6] . Kidney stone risk has also been shown to be positively correlated with the ratio of visceral to subcutaneous fat tissue and nonalcoholic fatty liver disease [7] , [8] , [9] , [10] .…”