Association of Neutrophil Gelatinase-Associated Lipocalin With the Severity of Coronary Artery Disease

Zografos, Theodoros; Haliassos, Alexander; Korovesis, Socrates; Giazitzoglou, Eleftherios; Voridis, E; Katritsis, Demosthenes G.

doi:10.1016/j.amjcard.2009.05.023

Cited by 91 publications

(66 citation statements)

References 19 publications

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“…81 Zografos et al reported that serum NGAL levels were significantly higher in the presence of CAD and correlated with its severity. 82 Also, in HF, increased myocardial expression of NGAL might be one of the mechanisms for its prognostic value, independent of coexisting renal injury. 83 Yndestad et al reported strong immunostaining in cardiomyocytes within the failing myocardium in both experimental and clinical HF.…”

Section: Ngal In Hfmentioning

confidence: 99%

Heart Failure, Chronic Kidney Disease, and Biomarkers - An Integrated Viewpoint -

Iwanaga

Miyazaki

2010

Circ J

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Chronic kidney disease (CKD) is frequently associated with a progressive decrease in the glomerular filtration rate, which leads to endstage renal disease (ESRD). Heart failure (HF) is a complex syndrome rather than a primary diagnosis, and considered as the endpoint of all cardiovascular disorders. It is the leading cause of death among the cardiovascular diseases in patients with CKD and ESRD. There is some interaction between the heart and kidney (the so-called "cardiorenal syndrome"), and HF patients with the complication of CKD or ESRD show a worse prognosis. Thus, early diagnosis and aggressive management of HF are needed in patients with CKD and ESRD. A number of biomarkers appear to have growing clinical importance and are reported for detection and stratification of HF. Although HF and CKD have a close interrelationship, the utility of the biomarkers has not been adequately studied with regard to the relationship with renal dysfunction. This paper reviews of the current evidence about laboratory biomarkers in patients with HF or CKD, emphasizing the emerging cardiac biomarkers (ie, BNPs and cardiac troponins), and the biomarkers of renal injury (ie, cystatin C and neutrophil gelatinase-associated lipocalin). Furthermore, it discusses the potential role of these markers in terms of heart -kidney interactions and their utility in the diagnostic and therapeutic strategies for cardiorenal syndrome. (Circ J 2010; 74: 1274 - 1282

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Section: Ngal In Hfmentioning

confidence: 99%

Heart Failure, Chronic Kidney Disease, and Biomarkers - An Integrated Viewpoint -

Iwanaga

Miyazaki

2010

Circ J

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“…In another study, the group of patients with CAD confirmed via angiography was compared to the groups of patients with normal coronary arteries, and serum NGAL levels were found to be significantly elevated in the presence of CAD (35). In a similar study, 47 patients with NSTEMI confirmed via angiography were compared to 45 control patients with stable angina (having undergone coronary angiography and determined to have normal coronary arteries), and NGAL levels were positively correlated to lesion complexity and the diffusiveness of CAD in patients with NSTEMI.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Prognostic Significance of Neutrophil Gelatinase- Associated Lipocalin and Pentraxin-3 in Acute Coronary Syndrome

Özer¹,

Ergin²,

Kılınç³

et al. 2017

EAJEM

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“…NGAL interacts with MMP-9, preserves it from degradation, and modulates its proteolytic activity [19], affecting coagulation [14,15]. It has been reported that NGAL levels are high in patients with CAD [20] and are related to the severity of the disease [8], and are increased in clinical and experimental heart failure [21]. However, although these findings suggest that NGAL may play an active pathophysiological role in the development of coronary events, none of them [8,20,21] demonstrate a direct relationship between NGAL and the priming of coagulation process.…”

Section: Discussionmentioning

confidence: 99%

“…NGAL was analysed using an enzyme-linked immunosorbent assay (ELISA) [8] supplied by Bioporto Diagnostic (Verona, Italy) in accordance with the manufacturer's instructions. Plasma antithrombin III was measured using colorimetric method, based on a chromogenic substrate: S-2765:N-Z-D-ARG-GLY-ARG-pNA using a kit provided by Instrumentation Laboratory (Milan, Italy) [9].…”

Section: Methodsmentioning

confidence: 99%

Identification of Factors Causing Sudden Coagulation in Patients with Acute Myocardial Infarction

Pinelli¹

2012

J Clin Exp Cardiolog

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Background: Coronary artery disease (CAD) evolving to acute myocardial infarction (AMI) is due to the thrombotic occlusion of coronary vessels in the presence of destabilized atheroma, rich in inflammatory cells secreting proteolytic enzymes that induce the development of thrombosis. The aim of this study was to analyse the plasma of AMI patients for the detection of proteases or factors that may cause fast coagulation.

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Association of Neutrophil Gelatinase-Associated Lipocalin With the Severity of Coronary Artery Disease

Cited by 91 publications

References 19 publications

Heart Failure, Chronic Kidney Disease, and Biomarkers - An Integrated Viewpoint -

Heart Failure, Chronic Kidney Disease, and Biomarkers - An Integrated Viewpoint -

Diagnostic and Prognostic Significance of Neutrophil Gelatinase- Associated Lipocalin and Pentraxin-3 in Acute Coronary Syndrome

Identification of Factors Causing Sudden Coagulation in Patients with Acute Myocardial Infarction

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